Sirtuins And The Molecular Epidemiology Of Frailty In Older Men
Funder
National Health and Medical Research Council
Funding Amount
$483,246.00
Summary
People in Australia are living longer and longer and yet little is known about the underlying biology of the ageing process. This project will investigate the role of a number of molecular and cellular factors in the aetiology of frailty in a group of more than 1400 older men who are already participating in the Concord Health and Ageing in Men Project. A particular focus of the project are sirtiuns, a group of enzymes recently found to be associated with longer life in several animal models.
Concord Hormones And Ageing In Men Project (CHAMP)
Funder
National Health and Medical Research Council
Funding Amount
$1,780,887.00
Summary
Throughout life men have poorer health than women, a health difference that extends into old age. In Australia in 2001, life expectancy for a 65 year old man was 20% less than for a 65 year old woman (81.6 years for men and 85.2 years for women). The study proposed here will fill major gaps in knowledge about key health problems in older men. The study will be called CHAMP: Concord Hormones and Ageing in Men Project. As people grow older, health problems that cause loss of independence and reduc ....Throughout life men have poorer health than women, a health difference that extends into old age. In Australia in 2001, life expectancy for a 65 year old man was 20% less than for a 65 year old woman (81.6 years for men and 85.2 years for women). The study proposed here will fill major gaps in knowledge about key health problems in older men. The study will be called CHAMP: Concord Hormones and Ageing in Men Project. As people grow older, health problems that cause loss of independence and reduced quality of life become increasingly important. The term 'geriatric giants' is sometimes used to describe these disabling syndromes: falls and fractures, cognitive impairment and dementia, urinary incontinence, and poor mobility and functional dependence. CHAMP has been designed to investigate the causes of, and inter-relationships between, these geriatric syndromes in men. Reproductive hormones are responsible for the fundamental biological differences between men and women. Underpinning CHAMP is the idea that age-related changes in reproductive hormones play an important role in the development of the geriatric syndromes in older men. There have been numerous studies of oestrogen and health in older women but only limited research on testosterone and other reproductive hormones in older men. CHAMP will be the largest study of the geriatric syndromes in older men ever conducted. The study will inlvolve 2800 men aged 65 years and over recruited from the community around Concord Hospital in Sydney. These men will each spend 3 hours at the study centre, where they will have a comprehensive physical examination and tests for osteoporosis, muscle weakness, dementia and urinary problems, as well as blood tests. This will all be repeated 2 years later.Read moreRead less
Determinants Of Musculoskeletal And Other Diseases, Health Service Utilisation And Mortality In A Cohort Of Older Women
Funder
National Health and Medical Research Council
Funding Amount
$869,724.00
Summary
This longitudinal study aims to identify determinants of musculoskeletal and cardiovascular diseases, cognitive decline, mortality and health service utilisation with ageing in a cohort of well-characterised older women, whose health has been monitored since 1998. This study is unique in that it will have followed patients from mean age 75 to 90 years with longitudinal clinical data collected and complete ascertainment of health service utilisation through the WA Data Linkage System.
Reliability Of An Online Geriatric Assessment Procedure
Funder
National Health and Medical Research Council
Funding Amount
$343,822.00
Summary
This study will examine the reliability, safety and cost of a novel new method of providing geriatrician assessment to older people in hospital. Nurses consult with the patient and enter their findings on a web-based software system that enables the geriatrician to review, report and make recommendations over the internet.
Defining Mechanisms Of Follistatin-mediated Muscle Adaptation, For Treatment Of Frailty And Muscle-related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$557,478.00
Summary
Physical frailty-weakness is one of the most common symptoms of serious illness and a key cause of death. I propose to study a new model of skeletal muscle growth, to learn more about the causes of wasting in muscle-related diseases. The work will identify cell mechanisms that cause loss of muscle strength, and will help develop novel treatment approaches to prevent or reverse physical frailty in illness. New therapies to combat frailty are vital to improve the health of our community.