The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
An epigenetic basis for foetal programming. The social and economic impact of adult-onset diseases such as diabetes, hypertension and atherosclerosis is increasing. Evidence indicates that a mother's nutrition influences the risk of her children developing some diseases later in life. This proposal aims to elucidate the mechanism underlying this phenomenon. By understanding the mechanism through which maternal nutrition affects disease risk, we may make it possible to design early diagnosis and ....An epigenetic basis for foetal programming. The social and economic impact of adult-onset diseases such as diabetes, hypertension and atherosclerosis is increasing. Evidence indicates that a mother's nutrition influences the risk of her children developing some diseases later in life. This proposal aims to elucidate the mechanism underlying this phenomenon. By understanding the mechanism through which maternal nutrition affects disease risk, we may make it possible to design early diagnosis and intervention strategies. Our work may suggest intervention strategies - such as supplementation of at-risk mothers with key molecules such as methyl donors - during foetal and early postnatal life, which could be key to preventing premature morbidity and mortality.Read moreRead less
The effect of mitochondrial and nuclear-cytoplasmic variation on longevity, metabolism and stress resistance in Drosophila. Much research points to a major role of free radical damage in aging, thus the belief that antioxidants might be beneficial in delaying aging. Free radicals are mostly formed in the subcellular organelles which consume oxygen and produce energy, and this may be the major site of age-related damage. This project seeks to understand the degree to which variation among these ....The effect of mitochondrial and nuclear-cytoplasmic variation on longevity, metabolism and stress resistance in Drosophila. Much research points to a major role of free radical damage in aging, thus the belief that antioxidants might be beneficial in delaying aging. Free radicals are mostly formed in the subcellular organelles which consume oxygen and produce energy, and this may be the major site of age-related damage. This project seeks to understand the degree to which variation among these subcellular organelles affect free radical damage and aging, using the fruitfly Drosophila melanogaster as a model organism.Read moreRead less
Genetics of longevity and the delay of post-reproductive senescence. Ageing of the population in the coming decades will cause an increasing health care burden. Diseases of ageing such as Alzheimer's, heart disease, Parkinson's and a range of cancers, as well as impairments of ageing such as reduced mobility and cognitive ability are all caused or exacerbated by oxidative stress. With some exceptions, current medical practices focus on surgical repair or drug therapy to alleviate symptoms of ag ....Genetics of longevity and the delay of post-reproductive senescence. Ageing of the population in the coming decades will cause an increasing health care burden. Diseases of ageing such as Alzheimer's, heart disease, Parkinson's and a range of cancers, as well as impairments of ageing such as reduced mobility and cognitive ability are all caused or exacerbated by oxidative stress. With some exceptions, current medical practices focus on surgical repair or drug therapy to alleviate symptoms of ageing rather than addressing the physiological causes of ageing itself. Our project will provide understanding of natural systems that prevent age-related senescence due to oxidative stress. The goal is to identify novel and natural ways to maximise the fitness, well-being and self-sufficiency of people as they age.Read moreRead less
The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perce ....The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perceive and manage important aspects of human diversity.Read moreRead less
Genetics of Postmenopausal Bone Loss. The major consequence of bone loss in our ageing society is fracture. At 50 years for women, the lifetime risk of sustaining an osteoporotic fracture is 50%. The consequences of these fractures, which can include reduced life expectancy, prolonged medical care, and loss of independence, have a profound socioeconomic impact in an ageing population. The proposed study offers a unique opportunity to examine the contribution of genetic factors to postmenopausal ....Genetics of Postmenopausal Bone Loss. The major consequence of bone loss in our ageing society is fracture. At 50 years for women, the lifetime risk of sustaining an osteoporotic fracture is 50%. The consequences of these fractures, which can include reduced life expectancy, prolonged medical care, and loss of independence, have a profound socioeconomic impact in an ageing population. The proposed study offers a unique opportunity to examine the contribution of genetic factors to postmenopausal osteoporosis.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI0560757
Funder
Australian Research Council
Funding Amount
$160,896.00
Summary
Identification and Characterisation of Genes involved in the Copper Regulation of the Human Alzheimer's Disease Amyloid-Beta Precursor Protein (APP) Gene. Alzheimer's disease (AD) is the most common form of dementia in the ageing population. This research project aims to identify and characterise new genes involved in the copper regulation of the Alzheimer's disease gene. This may lead to the development of novel therapeutic targets and clinical intervention strategies as well as early diagnost ....Identification and Characterisation of Genes involved in the Copper Regulation of the Human Alzheimer's Disease Amyloid-Beta Precursor Protein (APP) Gene. Alzheimer's disease (AD) is the most common form of dementia in the ageing population. This research project aims to identify and characterise new genes involved in the copper regulation of the Alzheimer's disease gene. This may lead to the development of novel therapeutic targets and clinical intervention strategies as well as early diagnostic procedures in preventative healthcare for the treatment of AD. The benefits would affect the international community as a whole, potentially minimising the socio-economic costs arising from the predicted world-wide increase in AD in the ageing population.Read moreRead less
New fermentation and purification production technologies for menaquinone-7 for promoting bone and cardiovascular health. We will develop a significantly more cost-efficient and environmentally friendly process for the production of vitamin K (menaquinone-7, or MK7) to manufacture food supplements for humans and animals. MK7 will increase bone regeneration and minimise the risk of cardiovascular disease. It has the potential to reduce the costs of these conditions for the community, and to incre ....New fermentation and purification production technologies for menaquinone-7 for promoting bone and cardiovascular health. We will develop a significantly more cost-efficient and environmentally friendly process for the production of vitamin K (menaquinone-7, or MK7) to manufacture food supplements for humans and animals. MK7 will increase bone regeneration and minimise the risk of cardiovascular disease. It has the potential to reduce the costs of these conditions for the community, and to increase the quality of life for Australia's ageing population. Orthopaedic diseases are also a major veterinary issue, and our advance should make MK7 a more widely used available supplementary food for animals such as horses and dogs. Read moreRead less
Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evol ....Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Read moreRead less
Testing the free radical theory of aging: do indicators of oxidative damage predict lifespan? Because of the Free Radical Theory of Aging, many millions of dollars are spent around the world on dietary antioxidants of unproven efficacy. Many millions of research dollars are spent providing support for this theory but few studies test it rigorously. The first major benefit of this research is worldwide; to refute, or to substantially enhance and focus the current support for the Free Radical Theo ....Testing the free radical theory of aging: do indicators of oxidative damage predict lifespan? Because of the Free Radical Theory of Aging, many millions of dollars are spent around the world on dietary antioxidants of unproven efficacy. Many millions of research dollars are spent providing support for this theory but few studies test it rigorously. The first major benefit of this research is worldwide; to refute, or to substantially enhance and focus the current support for the Free Radical Theory. This should help to rationalise and direct funding supplied to these areas. The second benefit is for Australia: aging is a fruitful area for research because of the high general public interest and for training because of its multidisciplinary nature, and funding in Australia is very low by international standards. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less