Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in s ....Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in solution with atomic detail. This knowledge can significantly accelerate drug development. It is otherwise only available from crystal structures that can not always be determined.Read moreRead less
Unifying Modern Approaches in Machine Learning. The proposed research will lead to better algorithms for some important machine learning problems that could lead to better tools for extracting useful knowledge from data such as in bioinformatics and sensor networks; it will strengthen an international collaboration with one of the world's top centres of machine learning research; it will contribute to an open source toolkit of machine learning algorithms which will put Australia on the map as a ....Unifying Modern Approaches in Machine Learning. The proposed research will lead to better algorithms for some important machine learning problems that could lead to better tools for extracting useful knowledge from data such as in bioinformatics and sensor networks; it will strengthen an international collaboration with one of the world's top centres of machine learning research; it will contribute to an open source toolkit of machine learning algorithms which will put Australia on the map as a provider of sophisticated machine learning software; it will provide training opportunities for several PhD students and a postdoc to work with some of the best machine learning researchers in the world.Read moreRead less