Ageing And Latelife Health: Calories, Macronutrients Or Branched Chain Amino Acids?
Funder
National Health and Medical Research Council
Funding Amount
$746,459.00
Summary
The prevailing dogma of ageing research has been that a substantive reduction in caloric intake maintained over a lifetime will delay ageing and age-related pathologies (caloric restriction - CR). Yet CR does not differentiate between the effects of reduced intake of calories versus specific macronutrients, nor can it assess the impact of balance of macronutrients. This application seeks to disentangle the role of CR and macronutrients on their effects on healthspan and lifespan in mice.
Interactions Between Protein Leverage, Variety, And Dietary Carbohydrate And Fat Content In The Control Of Energy Intake In Humans
Funder
National Health and Medical Research Council
Funding Amount
$580,950.00
Summary
Most attempts to understand human vulnerability to obesity have focussed on fat and carbohydrate, yet recent studies have shown a powerful role for protein: we eat more calories when dietary protein concentration is low. But how does protein interact with other aspects of the diet, notably the prodigious variety of foods available in modern environments and the balance of fat to carbohydrate? We will use controlled trials to investigate how these factors contribute to excess energy intake.
�Percent Daily Intake� Versus �Equivalent Walking Time�: Making Sense Of The Kilojoules On Food And Drink Labels
Funder
National Health and Medical Research Council
Funding Amount
$108,350.00
Summary
We have already established through a series of eight qualitative focus groups plus a pilot survey using a convenience sample that the Equivalent Walking Time (EWT) food label is considered more informative, useful, and difficult to ignore than other labelling systems. As such we now seek to test the EWT against other labelling systems in a more objective and robust fashion, using a much larger, representative sample.
The Role Of Gastric Vagal Afferents In The Food Intake Reducing Effect Of Oestradiol
Funder
National Health and Medical Research Council
Funding Amount
$317,739.00
Summary
Regulation of food intake is paramount for maintaining health. Nerves from the stomach serve as important regulators of food intake. These nerves can be modulated by chemical substances; however the importance of this modulation is not well defined. The sex steroid, oestradiol, has potent food intake reducing effects, but the mechanism for this is poorly understood. Thus, this fellowship will examine the role that oestradiol has in regulating food intake by acting on nerves within the stomach.
Building Evidence To Improve Health Through Optimal Diet
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
This research will focus on dietary patterns in population health across the life-course. We know little about how dietary patterns and their determinants vary across life and the impact of life-stage transitions on diet and health. This research will provide unique insights into dietary patterns of infants, children, young adults and older adults.
Exploring Mealtimes On Subacute Wards Using An Ethnographic Approach
Funder
National Health and Medical Research Council
Funding Amount
$45,668.00
Summary
This research aims to understand what mealtimes are like for staff and visitors on rehabilitation hospital wards, and what beliefs and attitudes they have about mealtimes. A mealtime program that aims to improve patients’ nutritional intake will be introduced, and how staff and visitors experience this change will be explored. This research will help healthcare organisations to navigate complex change within the healthcare system.
It is clear that the rate of obesity is increasing dramatically. Better therapeutic strategies are required to treat this debilitating disease. In this study we will determine the effects of sugary drinks on the amount of food eaten and subsequent changes in weight gain. By understanding how sugary drinks affect rates of weight gain we will be able to formulate better strategies to combat obesity.
Physical Activity Restores Energy Homeostasis In Obesity Through Hypothalamic Neurogenesis
Funder
National Health and Medical Research Council
Funding Amount
$334,053.00
Summary
The sensing of blood-borne signals by the brain is an important event in regulating appetite and energy expenditure. This sensing is blunted in obesity and contributes to over-eating. The aim of this research is to determine whether the sensing of these blood-borne signals can be restored in obesity by creating new cells in the key appetite controlling centres of the brain. The outcomes of this research will lead to a better understanding of how feeding behaviour can be modified to treat obesity ....The sensing of blood-borne signals by the brain is an important event in regulating appetite and energy expenditure. This sensing is blunted in obesity and contributes to over-eating. The aim of this research is to determine whether the sensing of these blood-borne signals can be restored in obesity by creating new cells in the key appetite controlling centres of the brain. The outcomes of this research will lead to a better understanding of how feeding behaviour can be modified to treat obesity.Read moreRead less