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Population Prevalence And Environmental-genetic Predictors Of Food Allergy In An Infant Cohort
Funder
National Health and Medical Research Council
Funding Amount
$551,642.00
Summary
This study will measure which children are at greatest risk of food allergy. We plan to recruit 5000 children to test for food allergies, as well as asking a range of questions on different lifestyle factors such as diet and history of allergies . If positive, participants will be invited to a hospital clinic for tests and treatment. This will allow us to describe the epidemiology of food allergy, and assist the development of better services for those with food allergy in the community.
Prevention And Improved Management Of Paediatric Food Allergy
Funder
National Health and Medical Research Council
Funding Amount
$479,882.00
Summary
There is an urgent need to prevent food allergy and better manage its consequences. My research will identify: causes of food allergy (primary prevention); factors leading to adverse events in food allergic children (secondary prevention); and the role of food allergy in the ‘atopic march’ i.e. progression to other allergic conditions (tertiary prevention). The results of my research will be used to update policy and practice guidelines to change behaviour and improve clinical care.
Understanding The Immune Mechanisms Leading To Resolution Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$602,472.00
Summary
Food allergy affects up to 10% of children and rates are rising. The greatest rise has been in peanut allergy which is the commonest cause of life threatening reactions. Currently, there is no cure for food allergy. Management relies on food avoidance which is impossible to achieve. Recent deaths in children from food allergy highlight the need for an effective treatment. This project will examine what happens when you grow out of peanut allergy. New information will lead to possible cures.
Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
The aim of this proposal is to test the safety of a novel immunotherapy based on Helicobacter pylori platform technology to treat childhood allergies. Repeated oral administration of killed H. pylori mimics colonisation in the stomach and assists the development of a balanced immune system without the associated disease risk of live H. pylori. To achieve this goal Professor Barry Marshall has assembled a cross-disciplinary team of experts from Industry, Academia and Clinic.
Modified Peanut Allergen Combined With A Novel Dietary Adjuvant As A Cure For Peanut Allergy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,130,021.00
Summary
Peanut allergy is common and there is no cure. Current studies of peanut immunotherapy have shown the effects are not generally long lasting with many side effects. We plan to study a novel form of oral peanut immunotherapy using modified peanut and a dietary fibre (modified starch) supplement. We have evidence that modified peanut may work to desensitise patients with less side effects and that the diet supplement protects animals from developing food allergy.
Centre Of Research Excellence In Eradicating Food Allergy: Prevention, Cure And Reducing Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$2,496,041.00
Summary
Australia has the highest reported rate of food allergy in the world. We aim to eradicate food allergy through improved prevention and cure, supported by evidence generated by our collaborative network of research. In addition, we aim to help prevent children with food allergy having anaphylaxis through improved public health policy and clinical pathways. As a second wave of the allergy epidemic, we are well positioned to turn back the tide of this newly emergent health threat to the public.
Risk Factors For Food Allergy And The Allergic March To Asthma In Childhood: The HealthNuts Study
Funder
National Health and Medical Research Council
Funding Amount
$1,876,796.00
Summary
Food allergy appears to represent a second epidemic of allergic disease. It is not known why some children grow out of their food allergy or how food allergy in the first year of life impacts asthma and allergy in later childhood. HealthNuts is a large study of 5300 children that can answer these questions. HealthNuts visited children at ages 1, 4 and 6 and requests funding to re-visit them at age 10. Results will help prevent children developing food allergy, asthma and the allergic march.
BCG Immunisation To Prevent Allergy In Children: An Intervention Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,187,260.00
Summary
There has been a dramatic rise in allergic diseases (asthma, eczema, food allergy) worldwide and particularly in Australia, with up to 30% of children affected. There is evidence from small studies that BCG immunisation has beneficial effects that prevent an allergic type immune response later in life. In a large randomised trial we will determine whether BCG at birth prevents allergic disease by monitoring eczema and food sensitivity in infancy, both of which predict an allergic predisposition.
Maternal Diet Rich In Eggs And Peanuts To Reduce Food Allergies: A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$3,719,516.00
Summary
Food allergies now affect more than 1 in every 10 children. Recently, babies have been found to be at risk of developing a food allergy even before they start eating solid foods. We have discovered that baby immune responses can be improved by mothers eating more eggs during the first weeks of breastfeeding. Thus we are undertaking this research trial to determine whether mothers regularly eating more eggs and peanuts during pregnancy and breastfeeding will reduce food allergies in their babies.