A Concurrent Multiscale Model for Improved Prediction of Drying Process. This project aims to develop an innovative multiscale model for food drying, which integrates spatial and temporal nonlinear behaviours at different scales. The proposed unifying theory will capture dynamic micro level features and upscale them to macro level features through a concurrent bridging scheme. As cellular elements critically govern the drying process, the fundamental understanding captured through this theory wi ....A Concurrent Multiscale Model for Improved Prediction of Drying Process. This project aims to develop an innovative multiscale model for food drying, which integrates spatial and temporal nonlinear behaviours at different scales. The proposed unifying theory will capture dynamic micro level features and upscale them to macro level features through a concurrent bridging scheme. As cellular elements critically govern the drying process, the fundamental understanding captured through this theory will lead to more accurate prediction of drying kinetics, deformation and quality changes, and hence the development of efficient drying systems. This project will overcome a longstanding research problem and position Australia at the forefront in world drying research to reap substantial economic benefits for Australia.Read moreRead less
A next-generation whole parasite bovine Babesia vaccine. . In Australia, Babesia parasites cause most of the severe and often fatal cases of cattle-tick fever, a globally significant tick-borne disease. It can be prevented by a live-attenuated parasite vaccine which has critical limitations of a 4-day shelf-life and risk of severe disease if administered to adult cattle. This project aims to evaluate in cattle a novel whole parasite Babesia bovis vaccine that cannot cause disease and can be pres ....A next-generation whole parasite bovine Babesia vaccine. . In Australia, Babesia parasites cause most of the severe and often fatal cases of cattle-tick fever, a globally significant tick-borne disease. It can be prevented by a live-attenuated parasite vaccine which has critical limitations of a 4-day shelf-life and risk of severe disease if administered to adult cattle. This project aims to evaluate in cattle a novel whole parasite Babesia bovis vaccine that cannot cause disease and can be preserved as an off-the-shelf product without losing efficacy. The expected outcome is a significantly improved vaccine for a major infectious disease that affects primary food production. As the disease imposes a major economic burden, it will have great benefit for the Australian livestock industry.
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Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We ....Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We identified several Salmonella specific genes and subsequent murine studies revealed that a Salmonella mutant lacking these genes is attenuated in mice and especially in the gallbladder. In this project we seek to understand the molecular basis for attenuation and the contribution of each protein to diseaseRead moreRead less
Transforming Australian bio-based industries through multiscale modelling. Agricultural and forestry biomass can be converted into feedstocks for production of biofuels and biomaterials via synthetic biology. A key challenge is the complex biomass microstructure renders it highly resistant to conversion, and pretreatment is crucial for enhancing process efficiency. Micro-CT imaging will enable particle characterisation and identification of changes in the fibre composition during pretreatment. T ....Transforming Australian bio-based industries through multiscale modelling. Agricultural and forestry biomass can be converted into feedstocks for production of biofuels and biomaterials via synthetic biology. A key challenge is the complex biomass microstructure renders it highly resistant to conversion, and pretreatment is crucial for enhancing process efficiency. Micro-CT imaging will enable particle characterisation and identification of changes in the fibre composition during pretreatment. This information will be used to create a virtual biomass particle model for an in silico investigation to inform optimal process design. The framework will transform the way biomass is processed, contributing to the growth of the Australian bio-manufacturing industry by making it more productive, profitable and sustainable.Read moreRead less
A macrophage-centric holistic view of postnatal development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. It is also a time when animals are especially susceptible to infectious disease. This project aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animal models and a no ....A macrophage-centric holistic view of postnatal development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. It is also a time when animals are especially susceptible to infectious disease. This project aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animal models and a novel discovery to generate significant new knowledge that challenges current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology and may translate to improvements in health in animals and humans. Read moreRead less