Understanding The Impact Of Epigenetic Gene Regulation On Helicobacter Pylori Persistence And Pathogenesis.
Funder
National Health and Medical Research Council
Funding Amount
$757,896.00
Summary
Helicobacter pylori is a highly persistent pathogen and remains a significant problem worldwide, causing gastritis, peptic ulcer disease and gastric cancer. This project will increase our understanding of how H. pylori infection persists for the life of its human host and will provide knowledge that is critical in developing new strategies for preventing these infections.
The Effect Of Follicular Helper T Cells (TFH) On AID Regulation And Selection Of High Affinity Germinal Centre B Cells.
Funder
National Health and Medical Research Council
Funding Amount
$430,964.00
Summary
An integral component of an immune response to foreign pathogens is the production of antibodies by B cells. However, if antibodies react to self-antigens (human molecules rather than bacteria or viruses) they may also cause autoimmune diseases such as lupus. This research project is investigating the mechanisms that control antibody generation by B cells, and how these are dysregulated in autoimmune diseases, such as lupus.