Clinical Research Translation In Fluorescence-guided Surgery Of Brain Cancer: Developing A Surgical Endoscope With Enhanced Contrast
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This proposal aims to improve the life expectancy of brain cancer patients by developing a new neurosurgical optical imaging device. The technology will transform the recently developed fluorescence-guided surgery procedure, where the tumour is endowed with artificial fluorescence. Our state-of-the art technology will enhance the fluorescence detection beyond visual perception to help remove hard-to-detect small cancer cell clusters, resulting in more accurate surgical removal of tumours.
The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
Unravelling Mechanotransduction Pathways In The Heart
Funder
National Health and Medical Research Council
Funding Amount
$949,956.00
Summary
This project addresses the still unresolved question of involvement of mechanosensitive ion channels in heart hypertrophy and arrhythmias including ventricular arrhythmias. These pathological conditions are a cause of a broadening fiscal healthcare burden in Western societies. Consequently, investigating the role of this class of ion channels in heart disease presents a priority for medical science and a great opportunity to improve the health outcomes for the Australian people.
The initial step of T cell activation of how the external ligand binding is translated to an increase of receptor phosphorylation at the cytoplasmic side is remain poorly understood. It is believed that the loss of immune recognition in cancer and over reactivity in auto-immune diseases are caused by abnormality of this transmembrane signalling transduction. Clarification of this molecular machinery can provide a molecular basis of those diseases and guidelines of more effective therapies.
Design And Use Of Conductive Biopolymers In Neural Stem Cell Network Formation
Funder
National Health and Medical Research Council
Funding Amount
$74,055.00
Summary
Growing neural tissue from stem cells on an electrically conductive surface can improve cell growth over the short term, yet the functionality of the cells has never been fully established. We will investigate the use of polymers for facilitation of neural tissue growth from stem cells, test the functionality of the tissue produced, and investigate the effectiveness of implantation of the developed tissue into primates to supplement or replace damaged tissue.