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Optimisation Of The Supportive Care Of Adults With Severe Falciparum Malaria
Funder
National Health and Medical Research Council
Funding Amount
$239,346.00
Summary
In the last two decades the care of patients with severe malaria has been revolutionised by the discovery of new drugs that reduce the chance of dying by 30% when compared to the previous standard treatments. However even with the use of these drugs, up to 30% of adults and 10% of children with severe malaria will still die from the disease. We need a greater understanding of how malaria harms people so that we might develop new drugs and treatment strategies to improve outcomes.
Safer Fluid Resuscitation- Which (type), What (to Expect) And How (mechanisms)
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Intravenous fluid administration to patients is the most common clinical intervention, often done to help sick patents get better, however paradoxically it is associated with worsening oxygen levels and increased death rates. In humans and animal I have demonstrated increased respiratory dysfunction with its administration. This study aims to understand the efficacy, compare different types of fluids and establish safer fluid administration thereby decreasing patient suffering and death rates.
Exploring Neurological Complications In Animal Models Of Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$337,432.00
Summary
Diabetes causes ongoing damage to the central and peripheral nervous systems. Our research aims to understand the mechanisms of nervous system damage in diabetes by investigating changes in nervous system function overtime in animal models of pre-diabetes, type 2 diabetes and type 1 diabetes. This study specifically aims to utilize indices that can be correlated with measures obtainable in human studies and thereby achieve results with strong clinical relevance and potential for translation.
Impact Of Sleep In Pregnancy On Maternal And Child Weight-related Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The project aims to reduce obesity in future generations by understanding the link between sleep in pregnancy and weight-related health outcomes (diet, weight gain, body composition, glucose tolerance). Results will enable the development of sleep guidelines for pregnancy and an intervention to optimise health. This will inform pregnant women, health professionals and future obesity prevention policies on the effects of poor sleep on diet, metabolism and adiposity during pregnancy and beyond.
Improving Sleep Outcomes In Addicted Populations To Promote Recovery
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Sleep problems are one of the most common side-effects of people going through drug withdrawal and may play a role in predicting future relapse. This project will comprehensively examine the components of sleep that are disturbed in drug-using populations, identify biological markers that impact upon functional outcomes related to sleep behaviour, and pilot an intervention targeting improved sleep outcomes that could be incorporated into routine clinical practice.
The Role Of Sleep Disturbances In The Development Of Trauma-related Mental Health Disorders In Paramedics
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Poor sleep is common in emergency personnel at risk of trauma exposure. This research will investigate paramedics over their career, longitudinally examining the role of sleep in the development of trauma-related mental health disorders. Outcomes will guide sleep interventions to improve workforce wellbeing. Implications for treatment of trauma-related disorders will be delivered. The research is thus, of utmost importance clinically, and for Australia’s emergency workers and response capacity.
Translating Advances In Cell-free Fetal Nucleic Acids Into Better Perinatal Care
Funder
National Health and Medical Research Council
Funding Amount
$187,322.00
Summary
My overall aim is to translate advances in biotechnology into better care for pregnant women. My first aim is to study brain development by analyzing the fluid that surrounds the unborn baby. This work may provide more information to women about their baby’s expected outcome. My second aim is to evaluate the impact of new DNA technologies on the detection of genetic conditions in the baby before birth. This work will confirm if this new generation of tests is fulfilling our high expectations.
Relaxin-3 Systems In Brain: Neurophysiology And Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
The project aim is to better understand the function of a newly-discovered signalling molecule in the mammalian brain, know as relaxin-3. Recent research suggests that this chemical is vital for normal animal behaviour, such as arousal, stress, and learning and memory processes. This project will thoroughly characterise how this chemical modulates activity of brain regions that subserve behaviour in rats. This should reveal clinical implications of relaxin-3 in human behavioural disorders.