Why are many fungicide lead compounds active against pathogens in axenic culture but inactive when applied to infected plants? It is much cheaper and easier to screen compounds for fungicidal activity in vivo (that is against the fungus grown in axenic culture) than to test in planta. However, it is commonly observed that compounds active in in vivo screens do not subsequently prove to be active in planta. The aim of this project is to investigate the physiological, biochemical and genetics basi ....Why are many fungicide lead compounds active against pathogens in axenic culture but inactive when applied to infected plants? It is much cheaper and easier to screen compounds for fungicidal activity in vivo (that is against the fungus grown in axenic culture) than to test in planta. However, it is commonly observed that compounds active in in vivo screens do not subsequently prove to be active in planta. The aim of this project is to investigate the physiological, biochemical and genetics basis of this discrepancy and to attempt to provide tools that circumvent the problem. It is expected the project will generate novel information on the environment in the plant experienced by the fungus.Read moreRead less
A novel method of broad-acre weed seedbank management using a naturally occuring germination stimulant. The discovery of a novel butenolide that promotes seed germination has potential to provide significant economic benefits for Australia's agricultural sector, providing a vehicle to move towards minimum-weed agricultural systems achieved through broad-acre stimulation of the weed seedbank. Our aim is for butenolide to promote uniform release of weed seed dormancy, increased germination, and gr ....A novel method of broad-acre weed seedbank management using a naturally occuring germination stimulant. The discovery of a novel butenolide that promotes seed germination has potential to provide significant economic benefits for Australia's agricultural sector, providing a vehicle to move towards minimum-weed agricultural systems achieved through broad-acre stimulation of the weed seedbank. Our aim is for butenolide to promote uniform release of weed seed dormancy, increased germination, and greater synchrony in early stage seedling growth and thus more effective knock-down following herbicide applications.Read moreRead less
Mechanisms and manipulation of seed dormancy maintenance in annual ryegrass and other weed species. A better understanding of seed dormancy in annual ryegrass will lead to a greater variety of management options for removal of this weed from cropping zones, focusing on diminishing the weed seed bank. Additionally, the knowledge gained from the study of ryegrass could be applied to native species in terms of optimising germination of difficult species and conservation of seeds of rare species.
Development Of Miniaturized Microwave Catheter Antennas And Monitoring Systems For Transcatheter Ablation For The Cure O
Funder
National Health and Medical Research Council
Funding Amount
$161,500.00
Summary
The development of microwave cardiac ablation system is crucial to the development towards a permanent cure for cardiac arrhythmias. Cardiac ablation using microwave energy can overcome the limitations of current ablative energy such as laser and RF ablation. Based on the combined knowledge and experience of UTS and Westmead hospital researchers, the proposed research is to develop a working prototype of cardiac ablation system using microwave energy based on our patent. The ultimate aim would b ....The development of microwave cardiac ablation system is crucial to the development towards a permanent cure for cardiac arrhythmias. Cardiac ablation using microwave energy can overcome the limitations of current ablative energy such as laser and RF ablation. Based on the combined knowledge and experience of UTS and Westmead hospital researchers, the proposed research is to develop a working prototype of cardiac ablation system using microwave energy based on our patent. The ultimate aim would be to attract interested industry parties to take up for full production and commercialisation.Read moreRead less
The response of mitochondria to oxidative stress in plants. Crops encounter many situations in their environment which place them under stress. Reactive oxygen molecules produced in these situations act as messengers to trigger defence mechanisms but also cause cellular damage. Mitochondria are the subcellular compartments involved in energy production and are essential for plant development and growth. However, they also have been implicated in the response of plants to stress and pathogen atta ....The response of mitochondria to oxidative stress in plants. Crops encounter many situations in their environment which place them under stress. Reactive oxygen molecules produced in these situations act as messengers to trigger defence mechanisms but also cause cellular damage. Mitochondria are the subcellular compartments involved in energy production and are essential for plant development and growth. However, they also have been implicated in the response of plants to stress and pathogen attack, and in production of reactive oxygen molecules. This proposal seeks to investigate how mitochondria are involved in these processes, focusing on the role of terminal oxidases. Potential outcomes include crops better able to cope with environmental stress.Read moreRead less
New Methods And Guidelines For The Design, Analysis And Reporting Of Cluster-crossover And Stepped Wedge Randomised Trials In Clinical And Public Health Research
Funder
National Health and Medical Research Council
Funding Amount
$391,258.00
Summary
Cluster crossover and stepped wedge designs have emerged recently as study designs used in clinical and public health research settings. However, despite their use there has been very little methodological assessment of the statistical analysis methods used in current practice. The proposed research will assess the correctness of current methods and will produce a toolkit of state-of-the art, defensible trial design, analysis and reporting methods for the clinical/health researcher.
p-Adic Methods in Arithmetic Geometry. This project concerns algorithms for determining the number of
solutions to systems of polynomial equations over finite fields
by p-adic methods. Our goal is to determine a fundamental
invariant, the zeta function, appearing in arithmetic geometry,
whose characterization was the subject of the famous Weil
conjectures.
....p-Adic Methods in Arithmetic Geometry. This project concerns algorithms for determining the number of
solutions to systems of polynomial equations over finite fields
by p-adic methods. Our goal is to determine a fundamental
invariant, the zeta function, appearing in arithmetic geometry,
whose characterization was the subject of the famous Weil
conjectures.
We seek to understand and develop p-adic methods for determining
zeta functions, taking as point of departure the methods of Satoh
and Mestre for elliptic curves. Applications of this work include
public key cryptography and coding theory, having direct impact
in e-commerce and telecommunications.
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