Large-scale Randomised Evidence: The Reliable Detection Or Refutation Of Treatment Effects Through Large, Simple Randomised Trials And Collaborative Meta-analyses Of Trials Using Individual Participant Data
Funder
National Health and Medical Research Council
Funding Amount
$425,897.00
Summary
Randomised controlled trials are the most reliable scientific method of studying medical treatments. Well-designed trials are thus needed to confidently guide doctors, other health professionals and policy-makers, particularly for common conditions such as cardiovascular disease. This Fellowship will study how we can better prevent and treat cardiovascular disease through the design, conduct and analysis of such trials at the University of Oxford, a world-leader in randomised controlled trials.
Triple Therapy Prevention Of Recurrent Intracerebral Disease EveNts Trial (TRIDENT)
Funder
National Health and Medical Research Council
Funding Amount
$5,256,292.00
Summary
Acute intracerebral haemorrhage (ICH) is a serious form of stroke. Survivors of ICH are at high risk of repeat events. Blood pressure lowering is a very important to prevent repeat events but data shows blood pressure is poorly controlled in these patients. In this research we investigate whether an approach that uses a 'triple pill' strategy (3 low dose BP drugs in one pill) in ICH patients with mild to moderate hypertension can decrease major cardiovascular events.
A Randomised Evaluation Of The Appropriateness Of Anatomic Coronary Investigation In Cardiac Injury/MI Type 2
Funder
National Health and Medical Research Council
Funding Amount
$2,516,561.00
Summary
Myocardial infarction occurring in the context of another concurrent illness is associated with a higher morbidity, and mortality than patients presenting with spontaneous myocardial infarction. Significant variation in the use of coronary angiography for the investigation of these patients exists, and currently no trial evidence or guidelines define best practice. This trial will establish the optimal investigation and treatment approaches for the care of this very common clinical condition.
Development Of An Extended Release Oral Formulation Of Milrinone For Patients With Advanced Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$467,083.00
Summary
Heart failure is a debilitating condition associated with frequent hospitalization. Milrinone is an effective intravenous drug used to treat acute deteriorations. Previously, oral milrinone failed because of the lack of availability of appropriate formulations. We have developed an oral formulation which provides stable release of the medication. This application will evaluate the effectiveness of the drug in man and provide the documentation to take the project forward for partnership with indu ....Heart failure is a debilitating condition associated with frequent hospitalization. Milrinone is an effective intravenous drug used to treat acute deteriorations. Previously, oral milrinone failed because of the lack of availability of appropriate formulations. We have developed an oral formulation which provides stable release of the medication. This application will evaluate the effectiveness of the drug in man and provide the documentation to take the project forward for partnership with industry as a means to clinical translation.Read moreRead less
Novel Approaches To The Prevention And Treatment Of Chronic Heart Disease And Its Co-morbid Complications
Funder
National Health and Medical Research Council
Funding Amount
$5,793,580.00
Summary
Cardiovascular disease (CVD) and its associated additional disorders constitute major public health problems, especially given the rapidly ageing population which is increasingly affected by obesity and diabetes. This Program will explore novel therapies for the treatment of CVD and associated diseases, particularly focussing on chronic kidney disease, translating preliminary laboratory-based findings into clinical trials and then clinical and epidemiological findings into practice and policy.
LoDoCo2 Low Dose Colchicine For Secondary Prevention In Stable Coronary Heart Disease (the LoDoCo2 Trial)
Funder
National Health and Medical Research Council
Funding Amount
$2,399,884.00
Summary
We are conducting clinical trial in several thousand patients to assess the effect of a common, inexpensive and readily available anti-inflammatory drug, colchicine, on heart attack. Colchicine is widely used for treating gout, which is due to inflammation in joints. Since inflammation is an important process makes a cholesterol plaque unstable and can lead to coronary thrombosis and heart attack, we are hypothesising that cholesterol can limit this process.
The Impact Of Omega-3 Fatty Acids On The Inflammatory Mediators Of Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$48,028.00
Summary
Fish oils are consumed widely for their omega-3 fatty acids, which have multiple health benefits. Despite the benefits of fish oil for cardiovascular disease seen in early studies, recent studies have not shown a protective effect. Hence, we are studying the effects of omega-3s on the development of atherosclerosis (fatty plaque build up in arteries) by investigating their role in inflammation in the blood vessel wall and in fatty tissue. This is using cells, animals and human studies
CAPLA Study: Catheter Ablation For Persistent Atrial Fibrillation. A Multicentre Randomised Study Of Pulmonary Vein Antral Isolation (PVAI) Alone Vs PVAI With Posterior Left Atrial Wall Isolation (PWI)
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Atrial fibrillation (AF) is a common heart rhythm abnormality that affects quality of life with added health care costs. A minimally invasive procedure called catheter ablation (CA) is effective in controlling simple AF (paroxysmal AF) but the best ablation strategy to control a more resistant form of AF (Persistent AF) is unknown. This trial has been designed to address this key gap in knowledge by assessing if adding specific additional ablation to CA will improve outcomes.
The Impact Of Polyunsaturated Fatty Acids On Cardiovascular Events In The Endstage Kidney Disease Dialysis Population
Funder
National Health and Medical Research Council
Funding Amount
$1,076,284.00
Summary
Patients with kidney failure who require dialysis are at high risk for cardiovascular (CV) disease. Small studies suggest fish oil supplementation may protect dialysis patients against CV events such as heart attacks and strokes. We will study the impact of fish oil supplementation on reducing CV events in dialysis patients. If proven beneficial, it represents an easily accessible and inexpensive novel therapy to improve the lifespan of dialysis patients.
Randomised Controlled Trial Of Early Use Of A Simplified Treatment Regimen Incorporating A Half-dose, Three-in-one Blood Pressure Lowering Pill Vs. Usual Care For Improving Hypertension Control In India.
Funder
National Health and Medical Research Council
Funding Amount
$1,095,201.00
Summary
Hypertension affects a large proportion of the Indian population. Effective medications exist to lower blood pressure (BP) and the adverse effects of hypertension. However, complex medication regimes and the need to take multiple drugs can affect patient adherence to drugs, making it difficult to achieve good BP control. This research will investigate whether use of a simplified treatment protocol including a three-in-one BP lowering pill can improve BP control in Indians with hypertension.