A Single Fibre Study Of The Relationship Between Glucose Transport And Skeletal Muscle Contractility
Funder
National Health and Medical Research Council
Funding Amount
$284,625.00
Summary
Type 2 diabetes (a progressive disorder often accompanied by obesity) is claimed to be the most common metabolic disease in the world and is predicted to affect 1.15 million Australians by the year 2010. Muscle contraction (in the form of physical exercise or exercise training) is now an essential component in the management of type 2 diabetes and-or obesity.This project has been planned from a perspective that combines theoretical and experimental expertise in the field of muscle cell contracti ....Type 2 diabetes (a progressive disorder often accompanied by obesity) is claimed to be the most common metabolic disease in the world and is predicted to affect 1.15 million Australians by the year 2010. Muscle contraction (in the form of physical exercise or exercise training) is now an essential component in the management of type 2 diabetes and-or obesity.This project has been planned from a perspective that combines theoretical and experimental expertise in the field of muscle cell contractility with a keen interest in the role of skeletal muscle in glucose homeostasis. Work carried out within the scope of this project will contribute new insights into the pathogenesis of type 2 diabetes-obesity and new information on the cellular mechanisms involved in contraction-stimulated glucose transport by skeletal muscle. As part of this project we will develop single muscle cell-fibre preparations and appropriate protocols for monitoring cellular aspects of glucose transport in skeletal muscle. These preparations-protocols will have the potential to be used for testing anti-diabetic drugs directed towards intracellular targets. From an educational benefit point of view, the project will create the opportunity for 4-6 honours and 2-3 PhD students to acquire a rare and useful combination of skills and expertise in muscle cell biochemistry and physiology, while working on an issue of medical concern.Read moreRead less
Congenital Fibre Type Disproportion (CFTD): Disease Patterns And Pathogenesis Of Muscle Weakness
Funder
National Health and Medical Research Council
Funding Amount
$264,816.00
Summary
Congenital Fibre Type Disproportion (CFTD) is a type of genetic muscle disease that is caused by changes (mutations) in several different genes. Affected children usually have general muscle weakness from birth. We will compare medical findings and muscle MRI scans in different CFTD patients to develop guidelines for the care and diagnosis of CFTD patients. We will also study how gene mutations lead to weakness and the abnormalities seen on the muscle biopsy, focusing on the TPM3 gene.
Electronically Conducting Nanofibres and Assemblies. With the use of new techniques that have just emerged in the last two years and are receiving rapidly growing interest throughout the world, this project will bring to Australia a new nanofabrication platform for making a variety of complex nanostructures. Fundamental researches on these complex nanostructures will greatly advance nanoscience. New nanotechnologies will be developed to address some world-wide challenging problems, e.g. energy ....Electronically Conducting Nanofibres and Assemblies. With the use of new techniques that have just emerged in the last two years and are receiving rapidly growing interest throughout the world, this project will bring to Australia a new nanofabrication platform for making a variety of complex nanostructures. Fundamental researches on these complex nanostructures will greatly advance nanoscience. New nanotechnologies will be developed to address some world-wide challenging problems, e.g. energy conversion and storage, chemical/biological sensing and other micro- and nanoelectronic devices. This project will bring both breakthrough science and frontier technologies for building and transforming Australian industries and help place Australia at the forefront of nanotechnology. Read moreRead less
The characterization and pocessing of Australian grown hemp fibres. This project will, for the first time, systematically examine the characteristics and processing behaviour of Australian grown hemp fibres. The hemp industry is an emerging new industry in rural Australia. This research will tackle a number of complex problems concerning characterization, degumming, and processing of Australian grown hemp, and will engineer the finest and softest yarns as well as industrial products from this he ....The characterization and pocessing of Australian grown hemp fibres. This project will, for the first time, systematically examine the characteristics and processing behaviour of Australian grown hemp fibres. The hemp industry is an emerging new industry in rural Australia. This research will tackle a number of complex problems concerning characterization, degumming, and processing of Australian grown hemp, and will engineer the finest and softest yarns as well as industrial products from this hemp. This will position the local hemp industry as well fibre processing industry in a very strong position to meet the growing demand world wide on this "green" fibre.Read moreRead less
Understanding the Behavior of Single-Walled Carbon Nanotubes in Liquids. The imminent manufacture of Single Walled Carbon Nanotubes (SWNTs) at prices comparable to those of high-performance polymers such as Kevlar, will open up potential applications of SWNTs as high-performance fibres and coatings. A major challenge is the development of scalable processes for producing large objects made of SWNTs. This project, in collaboration with researchers at Rice and Stanford Universities, aims to unders ....Understanding the Behavior of Single-Walled Carbon Nanotubes in Liquids. The imminent manufacture of Single Walled Carbon Nanotubes (SWNTs) at prices comparable to those of high-performance polymers such as Kevlar, will open up potential applications of SWNTs as high-performance fibres and coatings. A major challenge is the development of scalable processes for producing large objects made of SWNTs. This project, in collaboration with researchers at Rice and Stanford Universities, aims to understand the principles that underlie the successful liquid state processing of SWNTs. The novel strategies that arise will cement Australia's position as a leading country for research in nanotechnology, and place it at the forefront of this field, with great potential for economic advantage.Read moreRead less
Childhood diabetes [both type 1- and young type 2-] is increasing alarmingly. Diabetes prevention will be a great benefit via both a healthier population and relief to the national health budget. To develop targeted preventive treatments we first need to identify genetic risk factors, requiring access to a large number of samples. We will establish a national Repository which will make DNA available to all qualified Australian researchers enhancing their ability to identify causes of diabetes.