Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100045
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Coherent Laser Links for Space Applications. Coherent laser links for space applications:
This project seeks equipment to establish a deployable, free-space, coherent laser link to enable Australia’s continued leadership and involvement in large-scale international space projects. It would support optical free-space frequency transfer to expand the capability of the European Space Agency’s Atomic Clock Ensemble in Space mission; tests to validate the inter-satellite interferometry acquisition s ....Coherent Laser Links for Space Applications. Coherent laser links for space applications:
This project seeks equipment to establish a deployable, free-space, coherent laser link to enable Australia’s continued leadership and involvement in large-scale international space projects. It would support optical free-space frequency transfer to expand the capability of the European Space Agency’s Atomic Clock Ensemble in Space mission; tests to validate the inter-satellite interferometry acquisition system for the NASA Gravity Recovery and Climate Experiment follow-on mission; and test-bed development for advanced coherent optical communications systems. Coherent, free-space laser links are an emerging technology for a range of high-impact research fields. The project would enable research relying on precision measurements of time and frequency; advanced inter-satellite laser interferometry, and coherent free-space optical communications. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100062
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Universal Optical Transmitter for rapid prototyping and system emulation. Universal optical transmitter for rapid prototyping and system emulation: This Project proposes an integrated, multi-user facility for the generation of extremely wide-bandwidth optical communication signals that will help to dramatically improve the data-handling capability of optical fibres and improve the energy efficiency of optical communication networks. The project will modulate the input of an advanced optical tran ....Universal Optical Transmitter for rapid prototyping and system emulation. Universal optical transmitter for rapid prototyping and system emulation: This Project proposes an integrated, multi-user facility for the generation of extremely wide-bandwidth optical communication signals that will help to dramatically improve the data-handling capability of optical fibres and improve the energy efficiency of optical communication networks. The project will modulate the input of an advanced optical transmitter with multi-level, multi-phase signals at multi-Gb/s rates to generate 'higher-order' modulation formats at multi- terra bits per second rates including orthogonal frequency-division multiplexing (OFDM), Nyquist-wavelength-division multiplexing (WDM), regular WDM and Optical Time-Division Multiplexing (OTDM). With this transmitter the project will investigate advanced optical communications concepts including 'constellations' of phase and intensity, limitations of nonlinearity in optical fibres, signal regeneration, and all-optical routing.Read moreRead less
Creating a national time and frequency network for Australia. This project will develop the means to distribute accurate time and frequency across the Australian continent via an optical fibre network. This network will meet the needs of future telecommunications, science and astronomy projects including the Australian bid for the Square Kilometre Array radio-astronomy project.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less