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From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Integrating teachers’ knowledge and affect to improve mathematics teaching and raise attainment. Mathematics teachers need to know their subject and how to teach it and need passion for the discipline and for inspiring their students to love it. They must believe that their students can learn mathematics and set high academic expectations for all of them. Knowledge and beliefs must be addressed in order to improve teaching, but exactly how can this be done? This project aims to build on existin ....Integrating teachers’ knowledge and affect to improve mathematics teaching and raise attainment. Mathematics teachers need to know their subject and how to teach it and need passion for the discipline and for inspiring their students to love it. They must believe that their students can learn mathematics and set high academic expectations for all of them. Knowledge and beliefs must be addressed in order to improve teaching, but exactly how can this be done? This project aims to build on existing work to develop theoretical insights that will lead to innovative approaches towards teacher change based on the integration of teacher knowledge and affect.Read moreRead less
Youth Gangs: The Australian Experience. Little systematic research has been undertaken in Australia into the nature and activities of youth gangs. The aim of this project is to provide a national study of youth group formations, processes of group transformation (toward or away from gangs), and strategies the might be employed to curtail gang formation and gang-related behaviour. The study will involve interviews with young people in each capital city, and focus group discussions with youth serv ....Youth Gangs: The Australian Experience. Little systematic research has been undertaken in Australia into the nature and activities of youth gangs. The aim of this project is to provide a national study of youth group formations, processes of group transformation (toward or away from gangs), and strategies the might be employed to curtail gang formation and gang-related behaviour. The study will involve interviews with young people in each capital city, and focus group discussions with youth service providers in each city. The research methods draw upon the instruments presently being developed by the Eurogang Research Network in order to facilitate cross-national comparisons. It will be the first national study of its kind, and will provide new conceptual insights into the character of youth group formation in Australia, baseline youth gang data, and analysis of possible intervention strategies.
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Powerful knowledge: mapping out standards of teachers' knowledge for teaching mathematics and English to achieve the goals of the curriculum. Setting standards is an important step to raising teacher quality. This project will establish benchmarks for teachers' knowledge at all levels of schooling in two key areas of the curriculum: English and mathematics.
Student retention beyond the compulsory schooling years in rural, regional and disadvantaged communities. This project will incorporate longitudinal mixed-methods study to investigate the factors that influence student retention in schooling beyond the compulsory years in rural, regional and disadvantaged communities. Research outcomes will identify best-practice educational strategies to enhance retention in such communities across Australia.
Building futures for young Australians at risk: a coordinated measurement framework and data archive. This project will build a national data base of evidence about and for programs that address the needs of the 16 per cent of young Australians currently at risk of school non-completion. It will generate important knowledge for program improvement and sustainability and coordination of evidence across diverse and fragmented programs.
Statistical literacy in the primary school: beginning inference. Australia is committed to building a stronger foundation for school mathematics and science. This project will introduce primary school students to beginning inference, a core component of statistical literacy and an increasingly important life skill. Foundations for secondary mathematics study and productive societal participation will be laid.
Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional educati ....Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional education and, where appropriate, other contexts. The research's economic benefit centres on gains for individuals, local communities, and the nation in enhancing regional students' academic achievements, sense of well-being and aspirations; leading to more productive citizens.Read moreRead less
Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The proj ....Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The project will deliver training for 3 PhD students at the interface between basic and applied research. A shortage of skilled scientists with ability to link understanding of plant development at the molecular/genetic level with improved crop management practices has been identified by the horticultural sector as a major challenge. Read moreRead less
The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that dr ....The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that drives expansion? How is expansion controlled spatially? These questions will be addressed in this project by comprehensive study of ion transport processes in a model organism, Neurospora crassa, using osmotic sensitive and transport mutants.Read moreRead less