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Birth Weight, Adult Weight And Podocyte Depletion.
Funder
National Health and Medical Research Council
Funding Amount
$796,252.00
Summary
A major role of our kidneys is to filter our blood. A key cell type in our kidney filters is an octopus-shaped cell known as the podocyte. If we are not born with enough podocytes, or if the filters grow too large after birth due for example to excessive weight gain, the podocytes cannot adequately filter the blood, and this can lead to kidney disease. We will measure podocyte endowment at birth, and assess the effects of weight gain and loss after birth on podocyte features and kidney health.
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandi ....Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandings of the literary knowledge that early career teachers need, of the impact of curricula and professional practice on disciplinary knowledge, and about the operation of literary studies across school and university. Significantly, it plans to use ‘literary sociability’, an innovative methodology, to generate empirical and conceptual perspectives on literary studies in Australia that will be of value internationally.Read moreRead less
Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the ....Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the most fundamental questions in the whole of biology: what is the basis for the primal distinction between sex and soma?Read moreRead less
Social, Environmental and Economic Sustainability in the Context of Melanesian Mining Projects. This is an interdisciplinary study of Melanesian understandings of socio-economic and environmental sustainability in the context of mining projects. It entails research into traditional ecological knowledge and assessment of ways that local understandings and expectations compromise programs based on Western scientific principles. It will examine local ideas about land use and food security, and the ....Social, Environmental and Economic Sustainability in the Context of Melanesian Mining Projects. This is an interdisciplinary study of Melanesian understandings of socio-economic and environmental sustainability in the context of mining projects. It entails research into traditional ecological knowledge and assessment of ways that local understandings and expectations compromise programs based on Western scientific principles. It will examine local ideas about land use and food security, and the social and cultural factors that determine responses to impacts of mining projects. The project will involve collaborative, interdisciplinary research, integrating social and cultural analysis and environmental and agrarian studies. It will contribute to current debates on environmentalism, mining impact and sustainable development.Read moreRead less
Getting a job: vocationalism, identity formation and schooling in communities at disadvantage. This research will use young people's stories to investigate the barriers and obstacles to getting a job, and from their vantage point, identify the educational, policy and practice contexts that need to be created and more widely sustained in order to assist their career aspirations and life chances.
Facilitating Capacity Building in the Australian Not-For-Profit Sector through Improved Work Learning. This project aims to investigate how both formal and informal work learning can improve the governance, leadership, and management capacity of not-for-profit organisations (NFPs). The research aims to identify key competencies, and chart the needs, opportunities, preferences, and barriers to develop them on a national scale. Organisational mechanisms under managerial control are further examine ....Facilitating Capacity Building in the Australian Not-For-Profit Sector through Improved Work Learning. This project aims to investigate how both formal and informal work learning can improve the governance, leadership, and management capacity of not-for-profit organisations (NFPs). The research aims to identify key competencies, and chart the needs, opportunities, preferences, and barriers to develop them on a national scale. Organisational mechanisms under managerial control are further examined to understand what facilitates work learning within NFPs. Findings aims to inform theory, practice and policy about professional development and capacity building to enhance NFPs’ ability to make a strong social impact. Outcomes aim to significantly strengthen Australia’s social and economic fabric by building effectiveness within the critical NFP sector.Read moreRead less
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.