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The first kernels of cardiovascular disease begin very early in life; in the womb and early infancy. These early indications are known to track into adulthood, eventually resulting in diseases such as heart attacks. Dr Huang has found that childhood obesity, high blood pressure, cholesterol and a "prediabetes" profile, cluster together and additionally are associated with many factors in the womb and first few years of life. She investigates how to give babies the optimal healthy start.
Consequences Of Elevated Maternal Glucocorticoids For Early Childhood Renal Development And Function
Funder
National Health and Medical Research Council
Funding Amount
$605,190.00
Summary
A growing body of evidence links maternal stress, such as that precipitated by financial problems or relationship issues (marriage break-up, physical or emotional abuse), with preterm birth and low-birth weight, which in turn has been linked to increased risk of adult disease. Our studies examine how maternal stress impacts on kidney development in childhood and sets the child on the path to cardiovascular disease in adulthood.
Reducing Cardiovascular Risk In Children Born With Poor Fetal Growth: The Small Baby Omega-3 (SO3) Trial
Funder
National Health and Medical Research Council
Funding Amount
$999,791.00
Summary
Poor fetal growth affects about 10% of people, and is a risk factor for high blood pressure and heart disease in adults. There is no current treatment to reduce the increased risk of heart disease due to poor fetal growth. This study will determine whether taking fish oils during infancy reduces arterial wall thickness, a sign of the disease that causes the majority of heart attacks, and lowers blood pressure in children who had poor fetal growth.
Non-invasive Assessment Of Vascular Health In Maternal-fetal And Other Susceptible Populations
Funder
National Health and Medical Research Council
Funding Amount
$402,679.00
Summary
The research in this application focuses on the development and refinement of non-invasive techniques for assessing subclinical atherosclerosis, and cross-disciplinary application of these techniques to identify cardiovascular risk factors and ‘at-risk’ individuals. Emerging and poorly understood risk factors of public health importance are a priority, and include: * Maternal-fetal health * Obesity * Indigenous health
Associate Professor Kate Denton is an internationally recognised cardiovascular researcher. A focus of Dr Denton’s research is to find out why women do not respond to current treatments as well as men, and how factors in pregnancy (nutrition, stress, alcohol) drive the development of cardiovascular disease in offspring. Dr Denton is also leading research to understand why a new high blood pressure treatment (blocking nerves to the kidney) is proving more effective than expected.
Linking Early Heart Growth Stress And Adult Cardiopathology: A New Role For Autophagy
Funder
National Health and Medical Research Council
Funding Amount
$524,013.00
Summary
An enlarged heart at maturity is a major risk factor. The goal of this project is to understand how cardiac growth abnormality in the neonate contributes to adult growth pathology. We have recently discovered that a type of stress-triggered cell death (autophagy) is increased in rodent neonatal hearts which later become enlarged, and that this cell death is regulated by the hormone angiotensin II. We will study the mechanisms involved to identify intervention opportunities to normalize growth.
Prof Trevor Mori has held an NH&MRC Research Fellowship during 2008-2012. This grant will enable him to continue his research program into 2013-2017. Prof Mori is a biomedical research scientist. His research examines the role of diet and lifestyle on risk factors for cardiovascular disease. He also leads the cardiometabolic team examining risk factors in the Western Australian Pregnancy (Raine) Study.