Mapping The Neural Circuits Involved In Appetite And Feeding Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$404,892.00
Summary
My research project involves deconstructing the neural circuitry underlying feeding behaviour using innovative genetically-based methods. I aim to identify and characterise the major projections of the oxytocin-expressing neurons in the paraventricular hypothalamic nucleus, which have recently been identified as critical in the feeding neurocircuitry. This emerging field of research is predicted to transform our understanding and treatment of disorders such as obesity and anorexia nervosa.
Does Gastrostomy Improve The Lives Of Children With Severe Disability And Their Families?
Funder
National Health and Medical Research Council
Funding Amount
$645,101.00
Summary
Around 750 Australian children are born each year with severe intellectual disability. Problems may include feeding difficulties and frequent hospitalisations. Feeding via a gastrostomy tube into the stomach can be used. We will conduct a data linkage study in NSW and WA, and collect additional data in WA to investigate patterns of gastrostomy use and its safety, effectiveness and costs. Our findings will help the management of poor feeding in intellectual disability.
Feeding Disturbance And Hypothalamus Integrity In Early Frontotemporal Dementia
Funder
National Health and Medical Research Council
Funding Amount
$428,319.00
Summary
Frontotemporal dementia accounts for 12-20% of all dementia cases. It is as common as Alzheimer�s disease in the < 65 year olds but understanding of this disease remains limited. Marked eating disturbance (overeating, snatching food) is a common clinical manifestation. This project will characterise this deficit and define its biological causes using blood tests and magnetic resonance imaging. Results will help in designing therapeutic interventions targeting this disabling feature.
Interactions Of Gastric Hormones With Vagal Afferent Pathways And The Role Of This System In Obesity
Funder
National Health and Medical Research Council
Funding Amount
$550,918.00
Summary
When we feel full after a meal it is the result of a variety of different nerve signals from the gut in response to distension of the stomach and specific nutrients. These signals are disordered in obesity and this project aims to find out how to correct this problem in this modern day epidemic.
Early Regular Egg Exposure During Infancy To Prevent Egg Allergy: A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$2,304,911.00
Summary
Food allergies are common and result in a significant burden to families and the health care system. One approach to prevent food allergies may be to introduce specific foods earlier than currently recommended. The study will compare early regular introduction of egg from 4-6 months compared to the more common practice of egg avoidance until 10 months of age. If successful at reducing egg allergy, this approach will have a significant impact on reducing the burden of allergic disease.
Promoting Protective Feeding Practices To Prevent Childhood Obesity: Follow Up Of A Successful Obesity Prevention Program Commencing In Infancy.
Funder
National Health and Medical Research Council
Funding Amount
$846,965.00
Summary
Almost one in four Australian children are overweight by the time they start school and at increased risk of becoming overweight adults. This study will evaluate if an intervention to equip parents with the confidence and skills to initiate and maintain positive early feeding practices can foster healthy food preferences, dietary intakes and eating patterns and growth up to five years of age. This is consistent with government focus on early childhood as the foundation for health and well-being.
Does Bovine Lactoferrin Prevent Death Or Disability In Very Low Birthweight Infants? Childhood Follow Up In The NHMRC LIFT Study
Funder
National Health and Medical Research Council
Funding Amount
$1,474,012.00
Summary
Our international consortium of investigators proposes to undertake follow up in survivors among 1,500 very low birth weight preterm infants enrolled in the NHMRC Lactoferrin Infant Feeding Trial, which is designed to evaluate whether low-cost oral lactoferrin supplementation reduces death and disability in early childhood.