Cortical Networks That Integrate Auditory Input And Speech Motor Output In Human Stutterers
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Stuttering is a chronic communication disorder that arises from problems in the brain processes that control speech. This research aims to use magnetoencephalography, a new and extremely fast method of brain imaging, to study the parts of the human brain that underlie speech production. By studying the brains of both child and adult stutterers the causes of stuttering will become more apparent. Ultimately, this research will lead to more effective treatments for stuttering.
Role Of Brain Serotonin In Animal Models Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$175,550.00
Summary
There is increasing evidence that deficiencies in the release of a brain chemical called serotonin play an important role in the development of schizophrenia. Post-mortem studies have shown changes in the levels of 'receptors' (keyholes for messenger chemicals in the brain) for serotonin in schizophrenia. In addition, in the treatment of schizophrenia, the more recently introduced 'atypical' antipsychotic drugs are superior to the more traditional 'typical' antipsychotics in terms of efficacy an ....There is increasing evidence that deficiencies in the release of a brain chemical called serotonin play an important role in the development of schizophrenia. Post-mortem studies have shown changes in the levels of 'receptors' (keyholes for messenger chemicals in the brain) for serotonin in schizophrenia. In addition, in the treatment of schizophrenia, the more recently introduced 'atypical' antipsychotic drugs are superior to the more traditional 'typical' antipsychotics in terms of efficacy and side-effect profile. Typical antipsychotic drugs act mainly through blockade of receptors for a brain chemical called dopamine. Atypical drugs appear to have additional actions, in particular blocking the effect of serotonin in the brain. This evidence is mostly circumstancial, relying to a large extent on biochemical analysis of brain regions and 'receptors' on which antipsychotics MAY act. It is currently unclear exactly how and where in the brain changes in serotonin activity influence behavioural processes causing schizophrenia. It is also unclear how and where typical and atypical antipsychotic drugs interact with the role of serotonin in schizophrenia. In this project we intend to inactivate specific parts of the serotonin system of otherwise intact, freely moving rats. Using behavioural observation methods relevant for schizophrenia, we will analyze if and how these interventions influence the behaviour of these rats. The results can have important implications for our fundamental understanding of the involvement of serotonin in the brain in schizophrenia.Read moreRead less
A Multi-national Trial To Predict Treatment Response In Subtypes Of Depression
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Treatment of MDD using trial and error can have serious consequences. It can prolong the patient’s suffering (depression is associated with substantial morbidity, and mortality), prolong their absence from work and other productive activity and increase the burden on their family-carers. This multi-national study will collect genetics, brain function and behavioural data from a large number of participants, allowing for sensitive predictors of response to be determined.
Understanding and manipulating stress physiology of eucalypt seedlings to improve survival and growth. Eucalyptus globulus and E. nitens are the major species being established to meet the 2020 Vision (Anon 1999) of trebling Australia's plantation estate. Seedling mortality and/or reduced growth after planting, linked to the transition from ideal growing conditions in the nursery to stressful conditions (high drought and browsing risk) at the planting sites, significantly increase the costs of ....Understanding and manipulating stress physiology of eucalypt seedlings to improve survival and growth. Eucalyptus globulus and E. nitens are the major species being established to meet the 2020 Vision (Anon 1999) of trebling Australia's plantation estate. Seedling mortality and/or reduced growth after planting, linked to the transition from ideal growing conditions in the nursery to stressful conditions (high drought and browsing risk) at the planting sites, significantly increase the costs of plantation production. By investigating physiological mechanisms of seedlings and their responses to drought and browsing stress during establishment in the field, methods for the production of seedlings acclimated to drought or browsing stress will be developed. The research outcomes will help maximise the financial return on over $28 M per annum being invested by the 8 project partners in seedling production and planting over 80, 000 ha per year for the next 19 years to meet the requirements of Vision 2020.Read moreRead less
Guiding early silvicultural interventions through predicting canopy and crown dynamics in plantations of sub-tropical eucalypts. This project aims to establish the scientific basis for silvicultural treatments of eucalypt plantations for clear wood production. While eucalypt plantations in north-eastern NSW have dramatically increased in recent times, the knowledge base for the production clear, branch-free wood from the tree species used does not exist. A physiological, mechanistic understandin ....Guiding early silvicultural interventions through predicting canopy and crown dynamics in plantations of sub-tropical eucalypts. This project aims to establish the scientific basis for silvicultural treatments of eucalypt plantations for clear wood production. While eucalypt plantations in north-eastern NSW have dramatically increased in recent times, the knowledge base for the production clear, branch-free wood from the tree species used does not exist. A physiological, mechanistic understanding of crown and canopy dynamics as well as branch shedding will form the scientific foundation for stand manipulations such as pruning and thinning to enhance wood quality. Project outcomes will provide the basis for a stand management simulation model for the most important eucalypt species.Read moreRead less
Developing eucalypt plantations for pharmaceutical flavanone production. The project aims to produce the tools and knowledge required to establish plantations of mallee eucalypts for the production of pinocembrin and structurally related flavanones. This is important because these flavanones have been shown to have a range of medicinal applications, including treatment of diseases of the central nervous system. The research plans to focus on producing and establishing trees with improved flavano ....Developing eucalypt plantations for pharmaceutical flavanone production. The project aims to produce the tools and knowledge required to establish plantations of mallee eucalypts for the production of pinocembrin and structurally related flavanones. This is important because these flavanones have been shown to have a range of medicinal applications, including treatment of diseases of the central nervous system. The research plans to focus on producing and establishing trees with improved flavanone content and growth rates, and on understanding the biochemical mechanisms that underlie flavanone production and structural modification. Expected outcomes include supporting the development of profitable plantations in rural Australia and the establishment of plantations more widely in southern Australia, especially on marginal land.Read moreRead less