Do Breast Cancer Risk Factors Differ According To Underlying Genetic Susceptibility? A Pooled Analysis Of Prospective Studies From The NCI Cancer Cohort Consortium
Funder
National Health and Medical Research Council
Funding Amount
$418,581.00
Summary
We propose to use data from 23 international prospective cohort studies in the Cancer Cohort Consortium organised by the US National Cancer Institute to evaluate gene environment interactions for women who are at increased genetic risk of breast cancer. Our ultimate goal is to enhance the performance of clinical prediction tools and to develop targeted evidence-based strategies to mitigate the high absolute risk of breast cancer for women at increased genetic risk of the disease.
Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the lo ....Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the long-run effects of social and biomedical interventions and of investment in human capital. It will tell the grassroots history of the Australian penal and colonial experiments and it will form a scholarly coalition with the great community of family historians. Read moreRead less
The transition from secondary school to adulthood: Experiences and life outcomes for youth with an intellectual disability and their families. This project seeks to explore the challenges faced and outcomes achieved by students with an intellectual disability as they move from secondary school into adult life. The study will investigate the factors at an individual, educational, family, and societal level which positively and adversely affect outcomes for young people with an intellectual disab ....The transition from secondary school to adulthood: Experiences and life outcomes for youth with an intellectual disability and their families. This project seeks to explore the challenges faced and outcomes achieved by students with an intellectual disability as they move from secondary school into adult life. The study will investigate the factors at an individual, educational, family, and societal level which positively and adversely affect outcomes for young people with an intellectual disability and their families. Family impacts can include significant loss of income as parents may have to cease employment to care for their young adult who has limited employment or day placement options. Gaining the knowledge to minimise the disruption to family life, which often occurs at this time of transition, will lead to strengthening Australia's social and economic fabric.Read moreRead less
Improving social and economic outcomes for children of incarcerated mothers. This project aims to identify how children’s experiences of maternal incarceration shape their life course. These children are one of the most vulnerable yet invisible groups in society and are rising in number. This project intends to interrogate system contact with child protection, justice, education and health agencies using a unique linked dataset across 30 years and over three generations, to describe social and e ....Improving social and economic outcomes for children of incarcerated mothers. This project aims to identify how children’s experiences of maternal incarceration shape their life course. These children are one of the most vulnerable yet invisible groups in society and are rising in number. This project intends to interrogate system contact with child protection, justice, education and health agencies using a unique linked dataset across 30 years and over three generations, to describe social and economic outcomes and how prison, child and maternal characteristics affect them. The project expects to provide critical evidence that can inform prevention strategies, with the potential to disrupt intergenerational patterns of profound disadvantage and reduce the social and economic costs of maternal incarceration to individuals and society.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100660
Funder
Australian Research Council
Funding Amount
$358,731.00
Summary
Simulating social networks to understand how neighbourhood factors influence health. Where you live and who you know has implications for your health. This study will use social network models to understand how social characteristics of neighbourhoods influence health. The new insights gained will help policy makers to develop better strategies for reducing health inequalities and improving health outcomes.
Families with multiple and complex needs: refocusing on early intervention. Families with multiple and complex needs have been determined to be a priority group in Australia (National Child Protection Framework 2021-31). This study will fill the evidence gap by determining the typologies of families with multiple and complex needs and child protection involvement who face intersecting risk factors (e.g. family violence, mental health, intergenerational trauma, alcohol/drug use, justice involveme ....Families with multiple and complex needs: refocusing on early intervention. Families with multiple and complex needs have been determined to be a priority group in Australia (National Child Protection Framework 2021-31). This study will fill the evidence gap by determining the typologies of families with multiple and complex needs and child protection involvement who face intersecting risk factors (e.g. family violence, mental health, intergenerational trauma, alcohol/drug use, justice involvement, disability, poverty and housing insecurity). Intergenerational (child and parent) linked data in three states will be utilised to investigate these families longitudinal trajectories of system involvement and to identify opportunities for enhanced prevention, points of early intervention and service planning. Read moreRead less
Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated ser ....Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated service delivery across government. The project will also trial innovative data linkage models including the creation of data repositories to improve efficiency for data provision and access, which will have application nationally and enable more timely access to whole-population linked cross-sector data.Read moreRead less
Development of an 'ageing household' model for assessing medium to long-term vaccine impact in populations. As birth rates in developed and newly industrialising countries fall, so too do the number of households containing children, with implications for the spread of infections in families. We aim to study the influence of this phenomenon on the risk of common childhood infections, and the length of time that vaccines given in infancy will protect.