Development Of A Bioinformatic Tool For The Rapid Identification Of Candidate Disease Genes
Funder
National Health and Medical Research Council
Funding Amount
$436,367.00
Summary
Candidate disease gene prediction systems assist geneticists by using biological data to suggest genes likely to be causative of diseases in regions of the genome delineated by genetic studies. This area has been enabled by completion of the Human Genome Project and increased availability of high-throughput experimental data and sophisticated bioinformatic tools. Identification of disease genes will contribute to an understanding of disease, as well as its prevention, diagnosis, and treatment.
Understanding The Mechanisms Of Atrial Fibrillation: High Density Intra-operative Mapping
Funder
National Health and Medical Research Council
Funding Amount
$94,025.00
Summary
We hypothesize that: During atrial fibrillation, regions acting as short cycle length drivers will demonstrate characteristic sinus rhythm electrophysiology including conduction slowing and abbreviated refractoriness. We aim to correlate the nature of electrical activity in atrial fibrillation with that in sinus rhythm. We will focus on particular anatomic locations that have been shown to be regions of anisotropy and sites where short cycle length rotors have been observed. The anatomic locat ....We hypothesize that: During atrial fibrillation, regions acting as short cycle length drivers will demonstrate characteristic sinus rhythm electrophysiology including conduction slowing and abbreviated refractoriness. We aim to correlate the nature of electrical activity in atrial fibrillation with that in sinus rhythm. We will focus on particular anatomic locations that have been shown to be regions of anisotropy and sites where short cycle length rotors have been observed. The anatomic location and electrophysiologic (EP) characteristics of these regions will vary according to the underlying atrial substrate. We aim to characterise the differences in atrial electrophysiology in AF and sinus rhythm between different pathophysiologic substrates. With high density mapping targeted to critical anatomic sites it will be possible to determine the EP mechanism of short cycle length rotors. We aim to characterise the EP mechanism of these short cycle length regions by analysis of recordings from high density mapping plaques.Read moreRead less
Analysis Of Atrial Electrical Remodelling In Patients With Paroxysmal And Persistent Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$127,516.00
Summary
I am a cardiologist undertaking further training in the management of electrical abnormalities of the heart. My research will focus on the mechanisms responsible for atrial fibrillation, the most common serious heart rhythm disorder. I intend to do this by examining the nature of the electrical activity in patients with atrial fibrillation and comparing this to electrical activity in patients without this disorder, who are undergoing treatment procedures for their electrical disorder.
Atrial fibrillation (AF) is the most common cause for an irregular heart beat. Catheter ablation is the only potential cure and involves passing wires via veins in the leg into the heart to deliver discrete small burns(ablation) around the pulmonary veins (PV), the major source for AF. Unfortunately 30-50% of patients have recurrent arrhythmia due to reestablishment of electrical connections. This multicentre internation trial examines whether more (maximal) ablation will improve the outcomes of ....Atrial fibrillation (AF) is the most common cause for an irregular heart beat. Catheter ablation is the only potential cure and involves passing wires via veins in the leg into the heart to deliver discrete small burns(ablation) around the pulmonary veins (PV), the major source for AF. Unfortunately 30-50% of patients have recurrent arrhythmia due to reestablishment of electrical connections. This multicentre internation trial examines whether more (maximal) ablation will improve the outcomes of the procedure.Read moreRead less
Characterisation Of CFAE Wavefront Propogation In Human Persistent AF
Funder
National Health and Medical Research Council
Funding Amount
$418,612.00
Summary
Atrial fibrillation can be eliminated by a relatively new treatment called catheter ablation, which involves modification of the electrical properties of the heart using thin wires (catheters) passed up from the leg. Targeting areas where catheters record abnormal electrical activity improves results of catheter ablation, although it is uncertain what these recordings represent. The aim of this study is to characterize these abnormal electrical signals in an attempt to improve ablation outcomes.