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Interaction Of Genetic And Environmental Risk Factors In Eye Disease
Funder
National Health and Medical Research Council
Funding Amount
$456,641.00
Summary
I aim to discover the genetic risk factors associated with a debilitating infection of the front of the eye caused by an amoeba, and associated with water use and contact lenses; and dry eye disease, a condition affecting over 20% of the elderly, and has significant affects on quality of life and functioning. The relationship of genetic and environmental factors will lead to identification of at risk populations, novel treatment paradigms and more sophisticated diagnostic techniques.
Impaired Decision-Making And The Role Of Dopamine In Modulating Executive Function In Parkinson’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$390,468.00
Summary
Patients with Parkinson’s Disease (PD) often experience significant impairments in their ability to make decisions, even in the earliest stages of the disease. This project will use a combination of psychophysics, pharmacotherapy and functional neuroimaging to examine the decision-making impairments that occur in PD, and how they are modulated by dopamine. We anticipate our findings will lead to improvements in the diagnosis and management of the syndromes of executive dysfunction seen in PD.
Novel Morphological Retinal Vascular Features As Early Biomarkers Of Vision-threatening Eye Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$107,169.00
Summary
Vision loss is not just a personal health burden, but a huge socio-economical burden. Management of major vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma will be improved if we can successfully identified persons at risk of developing the disease before clinical presentation to benefit from preventive treatment. My research aims to contribute to the prediction of these blinding diseases using advanced computer imaging analysis for simpl ....Vision loss is not just a personal health burden, but a huge socio-economical burden. Management of major vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma will be improved if we can successfully identified persons at risk of developing the disease before clinical presentation to benefit from preventive treatment. My research aims to contribute to the prediction of these blinding diseases using advanced computer imaging analysis for simple retinal photographs.Read moreRead less
Plasticity Of Cone Bipolar Cells In Retinas With Visual Dysfunction.
Funder
National Health and Medical Research Council
Funding Amount
$328,261.00
Summary
Advances in stem cell research and gene therapy have shown great promise in their application to eye disorders that lead to blindness. This project will examine the capacity of nerve cells in the eye to remodel in the presence of visual dysfunction and subsequent recovery after gene therapy. The results from this study will therefore benefit current approaches employed for the reestablishment of vision in eye diseases.
Spatial Coding In The Primate Cortex During Eye Movements.
Funder
National Health and Medical Research Council
Funding Amount
$428,720.00
Summary
Every time we move our eyes, objects in the world change their positions on the retina, yet to us, their positions remain perceptually unchanged. This project seeks to understand how neurons in the primate brain combine visual input with signals about eye position to construct this stable representation of external space. The findings will help us understand and-or rehabilitate a host of nervous system dysfunctions, including schizophrenia, stroke, and paraplegia.
Assessing The Biogeography Of The Ocular Microbiota And The Impact Of Antibiotic Prophylaxis
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Using DNA sequencing, recent studies have identified a diverse community of bacteria on the eye, once believed to be sparsely populated by microbes. This project will identify what is the resident bacteria of the eye and where these bacteria reside on the eye. Also, after cataract surgery some individuals experience dry eye problems. This project will investigate if antibiotic therapy, necessary to prevent infection, disrupts the microbial communities on the eye leading to development of dry eye
Novel Approaches To Understanding Peripheral Vision In Patients With Central Vision Loss
Funder
National Health and Medical Research Council
Funding Amount
$367,101.00
Summary
The aim of my research is to develop novel interventions that enhance the peripheral vision of patients with central vision loss, and to investigate the neural correlates of visual perception in peripheral vision in typical adults. My research will inform rehabilitation strategies that optimise the visual function of patients with partial blindness, and provide a more thorough understanding of the underlying neural mechanisms that reduce the quality of peripheral vision.