Modelling TRPV4 Skeletal Disorders Using Human IPSCs
Funder
National Health and Medical Research Council
Funding Amount
$1,171,187.00
Summary
Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and new in vitro re-programing technology to induce them to form cartilage cells to produce “disease in a dish” models of human skeletal disorders. These models will allow us to answer questions about how specific mutations cause disease and identify potential therapies
Improving Muscular Dystrophy By Targeting The ADAMTS5 Metalloproteinase
Funder
National Health and Medical Research Council
Funding Amount
$658,571.00
Summary
Muscular dystrophy is a devastating childhood disorder. There is no cure and no effective therapy to stop the disease progressing to early death. Our pilot data show that muscular dystrophy in a mouse model is dramatically improved when the Adamts5 gene is inactivated. ADAMTS5 is an enzyme that remodels the extracellular matrix around cells. This suggests that inhibiting ADAMTS5 may be a new way to treat muscular dystrophy. We will test this idea in mice with muscular dystrophy
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100013
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
A sensitive tip-tilt wave-front sensor for the multi-conjugate adaptive-optics system on the Gemini south telescope. A sensitive tip-tilt wavefront sensor for the multi-conjugate adaptive-optics system on the Gemini South telescope: This project will construct a sensitive tip-tilt wavefront sensor for GeMS, the multi-conjugate adaptive-optics system on the Gemini South telescope in Chile. GeMS is a unique and revolutionary new system that delivers near-infrared images at similar resolution to th ....A sensitive tip-tilt wave-front sensor for the multi-conjugate adaptive-optics system on the Gemini south telescope. A sensitive tip-tilt wavefront sensor for the multi-conjugate adaptive-optics system on the Gemini South telescope: This project will construct a sensitive tip-tilt wavefront sensor for GeMS, the multi-conjugate adaptive-optics system on the Gemini South telescope in Chile. GeMS is a unique and revolutionary new system that delivers near-infrared images at similar resolution to the Hubble Space Telescope at optical wavelengths over wide fields. With this improvement in technology it will be possible to do this on much fainter objects than is currently possible using this new wave-front sensor. This will allow GeMS to routinely study the morphologies of external galaxies at high angular resolution - greatly extending its science scope. Sharper images will also be obtained for all objects that are currently accessible, leading to higher quality science data.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100201
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
A major upgrade to the Australia Telescope Compact Array. This project aims to upgrade the $150m CSIRO Australia Telescope Compact Array ("the telescope"), by replacing the signal processing electronics and doubling the bandwidth. This will significantly enhance the performance of the telescope, enabling more ambitious science by the 450 researchers and students who use it each year. For example, it will enable the telescope to study radio counterparts to Gravitational Wave sources, and it will ....A major upgrade to the Australia Telescope Compact Array. This project aims to upgrade the $150m CSIRO Australia Telescope Compact Array ("the telescope"), by replacing the signal processing electronics and doubling the bandwidth. This will significantly enhance the performance of the telescope, enabling more ambitious science by the 450 researchers and students who use it each year. For example, it will enable the telescope to study radio counterparts to Gravitational Wave sources, and it will enable it to make detailed observations of initial discoveries made with the Australian Square Kilometre Array Pathfinder and other Australian telescopes. In short, it will enable Australian researchers to do more ambitious research, and make more discoveries, across broad areas of astrophysics.Read moreRead less
Innovative solutions to enhance space situational awareness. This project seeks to significantly advance Australia's space situational awareness by researching advanced orbit prediction techniques. The development of novel space object orbit prediction techniques will greatly improve collision warnings for satellite operators that provide essential space-based services to Australian Government and industries.
Mass Assembly of Galaxies In the Cosmos: the roles of stars, gas, and metals. Swinburne's Centre for Astrophysics and Supercomputing is uniquely placed to tackle the outstanding 'super questions' of modern astronomy. We will utilise Australia's investment in current and future telescopes to unlock the process of galaxy assembly across cosmic time. New computing and instrumentation technologies will be developed. A further benefit is the training of young scientists to the highest level. The outc ....Mass Assembly of Galaxies In the Cosmos: the roles of stars, gas, and metals. Swinburne's Centre for Astrophysics and Supercomputing is uniquely placed to tackle the outstanding 'super questions' of modern astronomy. We will utilise Australia's investment in current and future telescopes to unlock the process of galaxy assembly across cosmic time. New computing and instrumentation technologies will be developed. A further benefit is the training of young scientists to the highest level. The outcomes of this research will further enhance Australia's international profile in astronomy.Read moreRead less
Peering through the Dark Ages with the Murchison Widefield Array. There is one large gap in our understanding of the early evolution of the universe, namely, when did the first sources of light appear? Resolution of this puzzle requires new observational and technical strategies, both in terms of telescopes and the analysis of observations. The Murchison Widefield Array, a major new radio telescope in Western Australia, is an international initiative under construction to tackle the problem. Thi ....Peering through the Dark Ages with the Murchison Widefield Array. There is one large gap in our understanding of the early evolution of the universe, namely, when did the first sources of light appear? Resolution of this puzzle requires new observational and technical strategies, both in terms of telescopes and the analysis of observations. The Murchison Widefield Array, a major new radio telescope in Western Australia, is an international initiative under construction to tackle the problem. This program will provide a significant Australian contribution at the forefront of modern cosmology.Read moreRead less
The morphological evolution of galaxies over cosmic time. Present-day galaxies look either red and round or blue and disc-like; this project will study galaxies that existed when the universe was one quarter its present age to understand how these different structures came about. To do this, the project will use a new high resolution near-infrared camera built at The Australian National University.