Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Engineering improved and multifunctional gene editing systems. Advances in genome editing have enabled the targeted modulation of gene expression in cells and provided new tools for biotechnology. This project will combine computational design and genetic selection to deliver the next generation of precision gene editing tools. These new technologies can be used for modification of genes in any cellular compartment and will be useful for understanding and improving energy metabolism. Increased c ....Engineering improved and multifunctional gene editing systems. Advances in genome editing have enabled the targeted modulation of gene expression in cells and provided new tools for biotechnology. This project will combine computational design and genetic selection to deliver the next generation of precision gene editing tools. These new technologies can be used for modification of genes in any cellular compartment and will be useful for understanding and improving energy metabolism. Increased cellular energy production can be harnessed to make valuable biological products, with unprecedented efficiency.Read moreRead less
The roles and regulators of new plant cells linked to root transport. Plant genomics has moved to the single cell resolution, allowing precise investigations of previously hidden cell types and cell states that respond to environmental stress and that vary among differentially adapted plant populations. Here, we will extend our pioneering efforts that have mapped and discovered novel root cell types, to determine their salt and nutrient stress responses, and to elegantly dissect the underling ca ....The roles and regulators of new plant cells linked to root transport. Plant genomics has moved to the single cell resolution, allowing precise investigations of previously hidden cell types and cell states that respond to environmental stress and that vary among differentially adapted plant populations. Here, we will extend our pioneering efforts that have mapped and discovered novel root cell types, to determine their salt and nutrient stress responses, and to elegantly dissect the underling causal genetic variation. The unique cell markers and regulatory networks will be validated with tissue specific and transgenic tools that can work across a host of plant species to reveal adaptive cellular responses to harsh environmental conditions.Read moreRead less
The technological transformation of sex: improving Australia's response. This project aims to enhance knowledge and explore important implications of new digital, mechanical or medical technologies that are transforming the sexual lives of many Australians. Privacy breaches and online harassment are among the challenges posed by these new technologies. The project intends to identify potential solutions to emerging problems as well as areas of policy, legal or educational systems that might faci ....The technological transformation of sex: improving Australia's response. This project aims to enhance knowledge and explore important implications of new digital, mechanical or medical technologies that are transforming the sexual lives of many Australians. Privacy breaches and online harassment are among the challenges posed by these new technologies. The project intends to identify potential solutions to emerging problems as well as areas of policy, legal or educational systems that might facilitate or mitigate their implementation. Expected outcomes include new evidence regarding the use of technologies in the sexual lives of Australians. This project can directly benefit people requiring an evidence base for policy development, law and regulation (including consumer protection), cyber-security and sex-education.Read moreRead less
Coordinating Innovation in Knowledge-Based Multinational Organisations. Integration into global supply chains is one of the fundamental challenges for manufacturing companies in Australia. This project seeks to identify the optimal design for coordinating innovation in globally-dispersed organisations. It will analyse three mechanisms for transferring knowledge within organisations: hierarchies, communities of practice, and social networks. Outcomes will include a new multilevel statistical netw ....Coordinating Innovation in Knowledge-Based Multinational Organisations. Integration into global supply chains is one of the fundamental challenges for manufacturing companies in Australia. This project seeks to identify the optimal design for coordinating innovation in globally-dispersed organisations. It will analyse three mechanisms for transferring knowledge within organisations: hierarchies, communities of practice, and social networks. Outcomes will include a new multilevel statistical network modelling framework and organisational designs to overcome barriers to knowledge-transfer, such as language, culture and distance. The project will collect and apply data from Boeing Global Technology, the international research arm of The Boeing Company, a world leading business with major subsidiaries in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100336
Funder
Australian Research Council
Funding Amount
$416,899.00
Summary
Superconducting diamond for investigating sources of interface noise. This project aims to identify and eliminate the sources of electro-magnetic noise at material interfaces, through the development of diamond as a model semiconductor/superconductor material system. The project expects to generate new understandings about the origin of these noise sources, using a combination of new nanofabrication developments and exquisite control over the surface chemical bonding of the diamond material. Exp ....Superconducting diamond for investigating sources of interface noise. This project aims to identify and eliminate the sources of electro-magnetic noise at material interfaces, through the development of diamond as a model semiconductor/superconductor material system. The project expects to generate new understandings about the origin of these noise sources, using a combination of new nanofabrication developments and exquisite control over the surface chemical bonding of the diamond material. Expected outcomes include enhanced understanding and control of noise sources in superconducting and quantum devices, and potentially a new material platform for the creation of superconducting quantum circuits. By supporting Australia's nascent quantum technologies industry this project will help support research training and a higher quality workforce, with the possibility for enabling job creation in the future.Read moreRead less
Enabling diamond nanoelectronics with metal oxide induced surface doping. This project aims to use diamond for radio frequency power electronics. This builds on the investigator’s success in controlling diamond surface conductivity using transition metal oxides. Diamond is highly desirable for building high-power, high-frequency electronic devices, particularly for use in electrical power control/conversion and telecommunication. The lack of effective and stable doping methods has impeded the re ....Enabling diamond nanoelectronics with metal oxide induced surface doping. This project aims to use diamond for radio frequency power electronics. This builds on the investigator’s success in controlling diamond surface conductivity using transition metal oxides. Diamond is highly desirable for building high-power, high-frequency electronic devices, particularly for use in electrical power control/conversion and telecommunication. The lack of effective and stable doping methods has impeded the realisation of this prospect. This project expects the high performance and technically viable device technologies will enable diamond electronic devices for applications in telecommunications, radars and the next-generation electricity grid.Read moreRead less
High-brightness, low-efficiency roll-off materials for augmented realities. The proposal aims to apply new materials design theory to create new classes of highly efficient materials and overcome device efficiency roll-off issue for next-generation transparent electronics. The project expects to advance new see-through technology through new materials and device architectures innovations. Expected key outcomes include novel highly efficient multi-nuclear metal complexes generation, establishment ....High-brightness, low-efficiency roll-off materials for augmented realities. The proposal aims to apply new materials design theory to create new classes of highly efficient materials and overcome device efficiency roll-off issue for next-generation transparent electronics. The project expects to advance new see-through technology through new materials and device architectures innovations. Expected key outcomes include novel highly efficient multi-nuclear metal complexes generation, establishment of new knowledge of materials’ structure-property relationship and fundamental understanding of device physics, creation of new transparent display pixels, new training of young scientists and new IPs generation, which will provide benefits to maximise Australia's competitive advantages and meet with global innovation need.Read moreRead less
Next-generation solid-state batteries to drive an automotive revolution. This project seeks to design and fabricate new solid-state silicon electrodes for advanced high energy, high stability lithium batteries. It is anticipated that this project will generate new knowledge in the area of battery electrode materials through an innovative combination of a soft plastic crystal electrolyte with a highly conductive glass ceramic electrolyte. Expected outcomes of this project include a greater unders ....Next-generation solid-state batteries to drive an automotive revolution. This project seeks to design and fabricate new solid-state silicon electrodes for advanced high energy, high stability lithium batteries. It is anticipated that this project will generate new knowledge in the area of battery electrode materials through an innovative combination of a soft plastic crystal electrolyte with a highly conductive glass ceramic electrolyte. Expected outcomes of this project include a greater understanding of electrolyte properties and an increase in the electrode cycle stability. This should provide significant benefits, such as the development of a new high capacity battery to promote the uptake of electric vehicles and lower Australia's carbon footprint.Read moreRead less
Built-in electric field, light co-driven materials for energy and sensing . This project aims to resolve critical, bottleneck issues in the development of photocatalysis and photoelectrochemistry - key technologies towards the realisation of a sustainable carbon-neutral society. This project expects to use an innovative strain-engineering approach establishing a built-in electric field within materials for highly efficient separation and transport of photoexcited carriers. Expected outcomes of t ....Built-in electric field, light co-driven materials for energy and sensing . This project aims to resolve critical, bottleneck issues in the development of photocatalysis and photoelectrochemistry - key technologies towards the realisation of a sustainable carbon-neutral society. This project expects to use an innovative strain-engineering approach establishing a built-in electric field within materials for highly efficient separation and transport of photoexcited carriers. Expected outcomes of this project are to create new, ground-breaking materials and/or nanosystems that overcome intrinsic weakness of conventional semiconductors and significantly improve their photocatalytic and photoelectrochemical performance, for the benefit of the utilisation of solar and light energy in energy, environment and health. Read moreRead less