Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100114
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as ....High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as well as validation of next generation sequencing data. The information generated is crucial to advancing knowledge in important research fields including infection and immunity, regenerative medicine, immune responses, biomarker discovery, drug discovery, biotechnology and agriculture.Read moreRead less
Smart materials from semi-soft particles. This project will combine precision polymer chemistry to material science to develop structured nanoparticles for applications in photonics and shape memory materials.
Remediation of groundwater using permeable reactive barriers. Permeable reactive barriers are passive subsurface installations that remove contamination from groundwater as it flows through a reactive substrate. This project will develop new permeable reactive barriers that will benefit the nation by building skills and knowledge in an area of growth in Australian industry, namely the rehabilitation of industrial lands and the protection and remediation of Australia's critical groundwater source ....Remediation of groundwater using permeable reactive barriers. Permeable reactive barriers are passive subsurface installations that remove contamination from groundwater as it flows through a reactive substrate. This project will develop new permeable reactive barriers that will benefit the nation by building skills and knowledge in an area of growth in Australian industry, namely the rehabilitation of industrial lands and the protection and remediation of Australia's critical groundwater sources. The project is aimed at remediating an industrially contaminated site in the Hunter Valley, New South Wales, thereby contributing to the environmental improvement of that region. The technology developed will have wide application to other sites, both nationally and internationally.Read moreRead less
Organic-inorganic hybrids via a combination of ring opening metathesis polymerisation, Thiol-Ene Click chemistry and Sol-Gel reactions. The research aims to develop a fast and efficient process for the preparation of advanced organic-inorganic materials. The successful completion of this research will yield new materials that may be exploited in advanced specialty applications including in biomedical and fuel cell areas.
Dyes and Pigments as Building Blocks for Novel High Performance Organic Semiconductors. Natural dyes and pigments are well known for their bright colours, photochemical and thermal stability, and cheap cost. Recently, the necessity of high performing materials in the organic electronics has stimulated a renaissance of these historical molecules and their subsequent derivatives into new families of ?-conjugated building blocks used to construct new donor-acceptor semiconductors. The aim of this p ....Dyes and Pigments as Building Blocks for Novel High Performance Organic Semiconductors. Natural dyes and pigments are well known for their bright colours, photochemical and thermal stability, and cheap cost. Recently, the necessity of high performing materials in the organic electronics has stimulated a renaissance of these historical molecules and their subsequent derivatives into new families of ?-conjugated building blocks used to construct new donor-acceptor semiconductors. The aim of this project is to explore various novel dyes, pigments and their derivatives for constructing outstanding materials for future organic electronics.Read moreRead less
Built-in electric field, light co-driven materials for energy and sensing . This project aims to resolve critical, bottleneck issues in the development of photocatalysis and photoelectrochemistry - key technologies towards the realisation of a sustainable carbon-neutral society. This project expects to use an innovative strain-engineering approach establishing a built-in electric field within materials for highly efficient separation and transport of photoexcited carriers. Expected outcomes of t ....Built-in electric field, light co-driven materials for energy and sensing . This project aims to resolve critical, bottleneck issues in the development of photocatalysis and photoelectrochemistry - key technologies towards the realisation of a sustainable carbon-neutral society. This project expects to use an innovative strain-engineering approach establishing a built-in electric field within materials for highly efficient separation and transport of photoexcited carriers. Expected outcomes of this project are to create new, ground-breaking materials and/or nanosystems that overcome intrinsic weakness of conventional semiconductors and significantly improve their photocatalytic and photoelectrochemical performance, for the benefit of the utilisation of solar and light energy in energy, environment and health. Read moreRead less
Diffusion – the key to performance in organic optoelectronic devices. In the future, new types of displays, solar cells and sensors for explosives based on organic materials will be common. This project will provide understanding and control of the movement of molecules between the layers that make up these devices leading to optimised performance and durability.
Discovery Early Career Researcher Award - Grant ID: DE180100294
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Topochemical conversion of layers of graphene into diamond-like thin films. This project aims to experimentally convert layers of graphene into diamond-like thin films via novel chemical hydrogenation and fluorination approaches. Unconventional diamond-like thin films that possess remarkable physicochemical properties will be produced to trigger significant theoretical and technological interests in nano-carbon research. The project expects to impact the fundamental understanding of this new cla ....Topochemical conversion of layers of graphene into diamond-like thin films. This project aims to experimentally convert layers of graphene into diamond-like thin films via novel chemical hydrogenation and fluorination approaches. Unconventional diamond-like thin films that possess remarkable physicochemical properties will be produced to trigger significant theoretical and technological interests in nano-carbon research. The project expects to impact the fundamental understanding of this new class of graphene-derived materials whilst driving cutting-edge technological advances in electrochemical applications, membrane technologies and quantum computing.Read moreRead less
Engineering better sprays for leaf coating: from drop impact to retention. This proposal aims to understand the performance of a unique rheological modifier that can enable an order of magnitude increase in coating efficiency for aerosol sprays while not affecting the quality of droplet formation during spraying. The effect occurs via a dispersed network of fibrous particles in water, providing a weak but useful ability to coat surfaces by responsively adjusting its structure. The material is ex ....Engineering better sprays for leaf coating: from drop impact to retention. This proposal aims to understand the performance of a unique rheological modifier that can enable an order of magnitude increase in coating efficiency for aerosol sprays while not affecting the quality of droplet formation during spraying. The effect occurs via a dispersed network of fibrous particles in water, providing a weak but useful ability to coat surfaces by responsively adjusting its structure. The material is expected to enable a broad array of applications, from agricultural treatments to nasal sprays, by exhibiting responsive behaviour at concentrations much lower than conventional modifiers require. The project will study the responsiveness of the system in single droplet, spray, and coating form as well as an active delivery system.Read moreRead less