Macrophage proteins: structure, function and e-science. The human genome was published five years ago, yet the functions of only a small fraction of the tens of thousands of encoded proteins are known. The development of smarter and faster methods for elucidating the structure and function of uncharacterised proteins is vital to a knowledge-based economy and a healthy society. The long-term benefits to the community will include fundamental new knowledge, generation of new pharmaceuticals and th ....Macrophage proteins: structure, function and e-science. The human genome was published five years ago, yet the functions of only a small fraction of the tens of thousands of encoded proteins are known. The development of smarter and faster methods for elucidating the structure and function of uncharacterised proteins is vital to a knowledge-based economy and a healthy society. The long-term benefits to the community will include fundamental new knowledge, generation of new pharmaceuticals and the development of new eScience approaches to streamline costs and efforts of research and to make science more accessible to the public.Read moreRead less
Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limit ....Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limitations and the convergence properties of the proposed
algorithms. The outcomes will be widely applicable in modelling of
large scale and complex data as is encountered in areas of
bioinformatics, physics and experimental studies of complex systems.
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Investigation and Development of Parallel Large Scale Record Linkage Techniques. Record linkage aims at matching records of the same entity (like customer or patient) in large (administrative) databases. The outcomes of the proposed research will improve current techniques in terms of efficiency, accuracy and the need for human intervention. Through experimental studies and stochastic modelling the performance of traditional and new methods for data cleaning, standardisation and linkage will be ....Investigation and Development of Parallel Large Scale Record Linkage Techniques. Record linkage aims at matching records of the same entity (like customer or patient) in large (administrative) databases. The outcomes of the proposed research will improve current techniques in terms of efficiency, accuracy and the need for human intervention. Through experimental studies and stochastic modelling the performance of traditional and new methods for data cleaning, standardisation and linkage will be assessed. The effect of the statistical dependency of attribute values will be studied. New methods using clustering for blocking large datasets, and predictive models including interaction terms will be implemented, analysed and evaluated on high-performance computers and office-based PC clusters.
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Efficient Synchronisation of Large Repositories. Accuracy and maintenance of vast quantities of data are essential for any modern society. The economy, health institutes and industries, and our defence and legal systems rely on having data being distributed widely and securely, and on queries being answered accurately and quickly. Complete synchronisation of databases is often impossible due to the limitations of internet bandwidth. Better compression techniques have the potential to allow crit ....Efficient Synchronisation of Large Repositories. Accuracy and maintenance of vast quantities of data are essential for any modern society. The economy, health institutes and industries, and our defence and legal systems rely on having data being distributed widely and securely, and on queries being answered accurately and quickly. Complete synchronisation of databases is often impossible due to the limitations of internet bandwidth. Better compression techniques have the potential to allow critical data to be distributed much more efficiently; we anticipate in some applications that the size of a compressed file could be reduced tenfold or more compared to previous best methods, leading to dramatic savings.Read moreRead less
Fast, practical and effective algorithms for clustering with advice. To maintain a safe and healthy society, government and industry need high quality immunization and national security databases. Since we cannot afford to have duplicate, incomplete and conflicting records that refer to the same person, we unify them by identifying clusters of related records.
In the emerging field of functional genomics, diagnosis of certain diseases is enhanced by determining which genes act together. Diffe ....Fast, practical and effective algorithms for clustering with advice. To maintain a safe and healthy society, government and industry need high quality immunization and national security databases. Since we cannot afford to have duplicate, incomplete and conflicting records that refer to the same person, we unify them by identifying clusters of related records.
In the emerging field of functional genomics, diagnosis of certain diseases is enhanced by determining which genes act together. Different experimental runs might result in different clusterings of genes: we need one consensus clustering that summarizes the experimental outcomes.
Cleaning databases and combining clusterings by hand would require vast amounts of time. This project will result in faster and more accurate computational procedures.Read moreRead less
Precision Pulsar Timing and its Applications. The rapidly rotating pulsars known as millisecond pulsars have period stabilities which rival that of the best terrestrial clocks. Observations of many millisecond pulsars spread across the sky should allow detection of the gravitational-wave background - likely to be the first direct detection of gravity waves. It will also enable establishment of a long-term time standard which is independent of and probably superior to that derived from terrestria ....Precision Pulsar Timing and its Applications. The rapidly rotating pulsars known as millisecond pulsars have period stabilities which rival that of the best terrestrial clocks. Observations of many millisecond pulsars spread across the sky should allow detection of the gravitational-wave background - likely to be the first direct detection of gravity waves. It will also enable establishment of a long-term time standard which is independent of and probably superior to that derived from terrestrial clocks. New analysis techniques and establishment of an international observing network will be required. Investigation and application of techniques for overcoming radio interference will be an important part of the project.Read moreRead less
Defeating Radio Frequency Interference. The radio spectrum is a valuable resource. Development of techniques which minimize the impact of various users on one another, allowing this resource to be shared, will benefit the entire community. For astronomy in particular, shared use is essential because of the very wide bandwidths needed to obtain sufficient sensitivity. Usage of the radio spectrum is increasing rapidly and radio telescopes are becoming more and more sensitive, compounding the probl ....Defeating Radio Frequency Interference. The radio spectrum is a valuable resource. Development of techniques which minimize the impact of various users on one another, allowing this resource to be shared, will benefit the entire community. For astronomy in particular, shared use is essential because of the very wide bandwidths needed to obtain sufficient sensitivity. Usage of the radio spectrum is increasing rapidly and radio telescopes are becoming more and more sensitive, compounding the problems. The digital signal processing techniques developed under this project will be widely applicable, not only to future radio astronomy facilities such as the Square Kilometer Array, but also to the communications industry generally.Read moreRead less
Transaction Oriented Computational Models for Multi Agent Systems. Agent systems are a very promising technology for constructing complex, large-scale software. Australian researchers have made key
contributions in this area, particularly with reference to one mature and commonly adopted agent architecture known as BDI (Belief, Desire, Intention). To make this technology suitable for use in advanced applications, it has to be provided with robust and predictable behaviour. This project wil ....Transaction Oriented Computational Models for Multi Agent Systems. Agent systems are a very promising technology for constructing complex, large-scale software. Australian researchers have made key
contributions in this area, particularly with reference to one mature and commonly adopted agent architecture known as BDI (Belief, Desire, Intention). To make this technology suitable for use in advanced applications, it has to be provided with robust and predictable behaviour. This project will address that need by designing and implementing a novel agent language for BDI, based on contributions using transactional concepts for agents developed at The University of Melbourne. This will contribute to the development of robust and predictable agent software, that can be used in complex and large scale applications of the future.
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The Time-Varying Eigenvalue Problem with Application to Signal Processing and Control. Linear models are ubiquitous in representing physical processes. Decomposing a linear model into its fundamental components is known as the eigenvalue problem. In applications as wide ranging as astronomy, aircraft control systems, Internet search engines and communication systems, it is necessary to perform this decomposition of a pertinent time varying linear model on the fly. This project aims to develop si ....The Time-Varying Eigenvalue Problem with Application to Signal Processing and Control. Linear models are ubiquitous in representing physical processes. Decomposing a linear model into its fundamental components is known as the eigenvalue problem. In applications as wide ranging as astronomy, aircraft control systems, Internet search engines and communication systems, it is necessary to perform this decomposition of a pertinent time varying linear model on the fly. This project aims to develop significantly faster and more accurate algorithms for this time varying eigenvalue problem than currently exist. Very modern techniques will be employed to achieve this aim, and the potential benefits to Australian hi-tech industries are great.
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Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will he ....Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will help to maintain high research profile of Australian researchers, to increase the capacity for consultancy and contract work, and provide a cutting-edge information technology for the Australian telecommunications industry, business and government (Priority 3 - Frontier Technologies). Read moreRead less