Multi-service assessment of intertidal treatment wetlands. This project aims to investigate the use of constructed intertidal wetlands to reduce nitrogen pollution while providing co-benefits including carbon sequestration and biodiversity. This research will generate a holistic assessment of the services, disservices, and cost-effectiveness of intertidal treatment wetlands compared to traditional wastewater treatment approaches. Expected outcomes include a full-scale multi-disciplinary environm ....Multi-service assessment of intertidal treatment wetlands. This project aims to investigate the use of constructed intertidal wetlands to reduce nitrogen pollution while providing co-benefits including carbon sequestration and biodiversity. This research will generate a holistic assessment of the services, disservices, and cost-effectiveness of intertidal treatment wetlands compared to traditional wastewater treatment approaches. Expected outcomes include a full-scale multi-disciplinary environmental and economic assessment of a constructed treatment wetland in a new urban development, providing industry and government partners the knowledge required to broaden uptake of intertidal wetlands as a cost-effective solution to growing levels of coastal anthropogenic pollution.Read moreRead less
Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster re ....Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster reef restoration that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of estuaries, and reestablish the environmental, economic and social benefits of oyster reefs.Read moreRead less
Ecosystem risk assessment. This project aims to develop a type-based framework for the world's ecosystems, and undertake the first broad-scale global risk assessment for ecosystems. It will include detailed Australian risk assessments and scenario analyses to develop sustainable management of ecosystem services and climate adaptation strategies. The outcomes include a global-scale framework for classifying terrestrial, freshwater and marine ecosystems, the first global Red List of Ecosystems and ....Ecosystem risk assessment. This project aims to develop a type-based framework for the world's ecosystems, and undertake the first broad-scale global risk assessment for ecosystems. It will include detailed Australian risk assessments and scenario analyses to develop sustainable management of ecosystem services and climate adaptation strategies. The outcomes include a global-scale framework for classifying terrestrial, freshwater and marine ecosystems, the first global Red List of Ecosystems and identified priorities for protecting remaining wild ecosystems and restoring those that have suffered degradation. This will help meet UN Sustainable Development Goals to improve human well-being globally.Read moreRead less
Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence ....Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence for better conservation and management. This will provide significant benefits by contributing to the future-proofing of Shark Bay’s World Heritage values to climate change, and more broadly by demonstrating the consequences of the continued tropicalisation of Australia’s coastline.Read moreRead less
Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Testing the importance of large-scale climate factors to plant community assembly following land-use change. This project will examine the native plant species and functional diversity of Australia's rain forest communities to create a predictive framework of how plant communities recover following deforestation. Such a framework is key to focusing conservation efforts in degraded and multi-use landscapes.
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less
Ecological valuation tools to protect seagrass during coastal development. Ecological valuation tools to protect seagrass during coastal development. Focussing on differences between shallow and deep seagrasses in the Great Barrier Reef, this project aims to develop a spatial valuation tool so resource managers and policy makers can minimise the effect of port development on seagrass ecosystems. Seagrasses provide ecosystem services (fisheries, nutrient cycling, primary productivity) worth trill ....Ecological valuation tools to protect seagrass during coastal development. Ecological valuation tools to protect seagrass during coastal development. Focussing on differences between shallow and deep seagrasses in the Great Barrier Reef, this project aims to develop a spatial valuation tool so resource managers and policy makers can minimise the effect of port development on seagrass ecosystems. Seagrasses provide ecosystem services (fisheries, nutrient cycling, primary productivity) worth trillions of dollars, but coastal development threatens this capacity. Resource managers lack accurate information about their potential effect and mitigation measures. Anticipated outcomes are protection of key marine environment and World Heritage Assets, and benefits to Australia’s economy through maintenance of ecosystem services and reduced risk associated with development.Read moreRead less
A Changing Climate on the Great Barrier Reef: Present and Future Implications. The Great Barrier Reef is fundamental to the economy of Australia. This national and international icon needs to be preserved in the face of a changing world to ensure on-going sustainability of our marine resources. Ocean acidification, warming water temperatures, increased freshwater disrupt the sensitive symbiotic association of corals the major structure building organisms of reefs. Understanding how these enviro ....A Changing Climate on the Great Barrier Reef: Present and Future Implications. The Great Barrier Reef is fundamental to the economy of Australia. This national and international icon needs to be preserved in the face of a changing world to ensure on-going sustainability of our marine resources. Ocean acidification, warming water temperatures, increased freshwater disrupt the sensitive symbiotic association of corals the major structure building organisms of reefs. Understanding how these environmental stressors result in the decrease in coral health is fundamental to prevent loss of our coral reefs and an important step towards preserving them for future generations.Read moreRead less