Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less
Interactions between nanoparticles and bacteria. This project aims to understand how nanoparticles interfere with bacterial metabolism, and how these interactions lead to cell death, lysis and dispersal from biofilms. Intensive use of nanomaterials results in their continuously releases into the environment. While various nanoparticles have inhibitory and even toxic effects on microorganisms in ecosystems, the underlying mechanisms are not understood. This project will investigate model organism ....Interactions between nanoparticles and bacteria. This project aims to understand how nanoparticles interfere with bacterial metabolism, and how these interactions lead to cell death, lysis and dispersal from biofilms. Intensive use of nanomaterials results in their continuously releases into the environment. While various nanoparticles have inhibitory and even toxic effects on microorganisms in ecosystems, the underlying mechanisms are not understood. This project will investigate model organisms’ responses to nanoparticles at the cellular, enzymatic and gene expression levels. The findings are expected to help assess the immediate and long-term effect of nanoparticles on ecosystem health, for improved environmental management.Read moreRead less
Single-atom catalysts for electrochemical carbon dioxide conversion. This project aims to develop a new synthetic technique for the fabrication of template-free and metal single-atoms embedded in doped carbon nano tubes. It will generate fundamental knowledge about multiple proton and electron transfer steps in carbon dioxide (CO2RR) using in-situ synchrotron characterisation techniques. Expected outcomes of the research include the development of new single-atom catalysts for production of the ....Single-atom catalysts for electrochemical carbon dioxide conversion. This project aims to develop a new synthetic technique for the fabrication of template-free and metal single-atoms embedded in doped carbon nano tubes. It will generate fundamental knowledge about multiple proton and electron transfer steps in carbon dioxide (CO2RR) using in-situ synchrotron characterisation techniques. Expected outcomes of the research include the development of new single-atom catalysts for production of the key feed-stock of CO for sustainable use in hydrocarbon fuels, providing significant benefits in the reduction of greenhouse emissions.Read moreRead less
Enabling diamond nanoelectronics with metal oxide induced surface doping. This project aims to use diamond for radio frequency power electronics. This builds on the investigator’s success in controlling diamond surface conductivity using transition metal oxides. Diamond is highly desirable for building high-power, high-frequency electronic devices, particularly for use in electrical power control/conversion and telecommunication. The lack of effective and stable doping methods has impeded the re ....Enabling diamond nanoelectronics with metal oxide induced surface doping. This project aims to use diamond for radio frequency power electronics. This builds on the investigator’s success in controlling diamond surface conductivity using transition metal oxides. Diamond is highly desirable for building high-power, high-frequency electronic devices, particularly for use in electrical power control/conversion and telecommunication. The lack of effective and stable doping methods has impeded the realisation of this prospect. This project expects the high performance and technically viable device technologies will enable diamond electronic devices for applications in telecommunications, radars and the next-generation electricity grid.Read moreRead less
Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882357
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Computational Facility for Multi-scale Modelling in Bio and Nanotechnology. Bio- and nanotechnology have the potential to transform Australian industry and research, and to bring significant benefits for consumers. The scope will include materials for energy storage, medical diagnostics and cellular imaging, bioengineering, drug and gene delivery, improved foods by molecular design, novel materials for electronics, improved techniques for particle processing, and molecular sieves for filtering ....A Computational Facility for Multi-scale Modelling in Bio and Nanotechnology. Bio- and nanotechnology have the potential to transform Australian industry and research, and to bring significant benefits for consumers. The scope will include materials for energy storage, medical diagnostics and cellular imaging, bioengineering, drug and gene delivery, improved foods by molecular design, novel materials for electronics, improved techniques for particle processing, and molecular sieves for filtering/purifying water and gases. The dedicated computing facility will enable a fast interactive cycle between simulation and experiment in these areas, accelerating the pace of research and applications.Read moreRead less
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100190
Funder
Australian Research Council
Funding Amount
$205,000.00
Summary
High through-put facility for measurement of quantum materials and devices. This projects aims to accelerate the development of quantum technologies by expanding our capacity to rapidly evaluate the low temperature electrical and optical properties of novel materials and devices. The project expects to generate new knowledge in quantum coherent phases of diamond, high mobility two-dimensional spintronics, hybrid semiconductor-superconductor devices, novel phases of silicon and germanium, and sin ....High through-put facility for measurement of quantum materials and devices. This projects aims to accelerate the development of quantum technologies by expanding our capacity to rapidly evaluate the low temperature electrical and optical properties of novel materials and devices. The project expects to generate new knowledge in quantum coherent phases of diamond, high mobility two-dimensional spintronics, hybrid semiconductor-superconductor devices, novel phases of silicon and germanium, and single photon sources based on silicon-carbide. Expected outcomes of the project include the establishment of high performing, efficient, new facilities for low temperature quantum measurement, the strengthening of collaborative links between participating researchers and the expansion of opportunities for research students.Read moreRead less
Special Research Initiatives - Grant ID: SR0354656
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Particulate Science and Technology Network. Particulate Science and Technology (PST) is a rapidly developing interdisciplinary research field concerned with particle-related phenomena at different time and length scales and represents a very significant research and development effort in Australia for many years. This network is formed by linking the world-recognized research centres/groups with different expertise. Its aim is to provide greater collaboration among the Australian and overseas re ....Particulate Science and Technology Network. Particulate Science and Technology (PST) is a rapidly developing interdisciplinary research field concerned with particle-related phenomena at different time and length scales and represents a very significant research and development effort in Australia for many years. This network is formed by linking the world-recognized research centres/groups with different expertise. Its aim is to provide greater collaboration among the Australian and overseas researchers and enhance the scale and focus of particulate research. It will help develop and maintain Australia's leading position in PST, generating massive research outcomes and training that can lead to improvement in resource, energy, process and allied industries.Read moreRead less