Discovery of pathways to embryogenesis in pathogenic flatworm parasites using microdissection and transcriptomic technologies. The cost to Australia of flatworm parasites to animal production and human health is substantial (hundreds of millions of dollars per year). This research will give new insights into how flatworms reproduce and equip their progeny for survival, providing impetus for new vaccine or drug therapies to be developed. As these pathogens are more significant in Australia's ne ....Discovery of pathways to embryogenesis in pathogenic flatworm parasites using microdissection and transcriptomic technologies. The cost to Australia of flatworm parasites to animal production and human health is substantial (hundreds of millions of dollars per year). This research will give new insights into how flatworms reproduce and equip their progeny for survival, providing impetus for new vaccine or drug therapies to be developed. As these pathogens are more significant in Australia's near neighbours, this project will strengthen Australia's international leadership in this field. Our study will provide, for the first time for any helminth parasite, a freely available genetic database that profiles the gene expression repertoire of individual parasite tissues, a development likely to enhance the international effort in controlling these harmful diseases.Read moreRead less
Beyond the gene: Linking herbivore behaviour to plant defense gene expression. This collaborative project investigates insect herbivore avoidance of plant defence mechanisms. Our project is novel because it integrates changes in the plant at a number of different levels and links them to insect foraging behaviour. Researchers assume that insects respond to plant defences by changing their foraging behaviour. This has not been tested directly. We use the genetically well characterised plant Arabi ....Beyond the gene: Linking herbivore behaviour to plant defense gene expression. This collaborative project investigates insect herbivore avoidance of plant defence mechanisms. Our project is novel because it integrates changes in the plant at a number of different levels and links them to insect foraging behaviour. Researchers assume that insects respond to plant defences by changing their foraging behaviour. This has not been tested directly. We use the genetically well characterised plant Arabidopsis and the world-wide pest Helicoverpa (heliothis) as a model system. Damage caused to crops by insect herbivores is a direct function of behaviour. Understanding this behaviour will lead to improved pest management and reduced economic losses.Read moreRead less
Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Promoting resilience of ecosystems through connectivity. The resilience of ecosystems in the face of major environmental disturbances is emerging as a major concern for modern ecology. Connectivity of ecosystem components is a critically important element of ecosystem function and should, theoretically, be central to system resilience. The relationship between connectivity and resilience, however, remains poorly substantiated by empirical data. By manipulating connectivity in laboratory experime ....Promoting resilience of ecosystems through connectivity. The resilience of ecosystems in the face of major environmental disturbances is emerging as a major concern for modern ecology. Connectivity of ecosystem components is a critically important element of ecosystem function and should, theoretically, be central to system resilience. The relationship between connectivity and resilience, however, remains poorly substantiated by empirical data. By manipulating connectivity in laboratory experiments using a well-understood model marine system, the project aims to determine how connectivity affects resilience. It could provide a crucial step towards integrating connectivity into management and conservation of natural resources.Read moreRead less
Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea. Australian sugar exports generate almost $2 billion in annual sales, making the sugar industry a critical facet of the Australian economy. In 2006, Australia's primary sugar producing region came under threat when an outbreak of sugarcane smut caused by the fungus Ustilago scitaminea first appeared in Queensland. Management of this potentially devastating disease has focused on breeding pr ....Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea. Australian sugar exports generate almost $2 billion in annual sales, making the sugar industry a critical facet of the Australian economy. In 2006, Australia's primary sugar producing region came under threat when an outbreak of sugarcane smut caused by the fungus Ustilago scitaminea first appeared in Queensland. Management of this potentially devastating disease has focused on breeding programmes aimed at developing resistant sugarcane cultivars, a complex process hampered by a lack of information about the mechanisms of smut resistance. Our research will provide key insight into the mechanisms by which U. scitaminea infects sugarcane, directing future breeding efforts and protecting this valuable industry against further outbreaks.Read moreRead less
Simultaneous analysis of root-derived plant defences and the associated microbiome. Australia is dependent on sustainable agricultural yields, which need to be maintained or improved. This production capacity is currently under threat by new and existing diseases which are predicted to worsen with climate change. This project will provide a global picture of how disease resistance and soil microbial communities are causally linked, and provide new strategies for disease control. In doing so, it ....Simultaneous analysis of root-derived plant defences and the associated microbiome. Australia is dependent on sustainable agricultural yields, which need to be maintained or improved. This production capacity is currently under threat by new and existing diseases which are predicted to worsen with climate change. This project will provide a global picture of how disease resistance and soil microbial communities are causally linked, and provide new strategies for disease control. In doing so, it will develop intellectual property (IP) and infrastructure that can be used in soil health management. This will provide many benefits to Australia, including sustainable agriculture in the context of climate variability and an increased demand for food, biomaterials and biofuels.Read moreRead less
Predicting the consequences of drought-induced mortality for tree species in a changing climate. Tree mortality will be a dramatic manifestation of climate change as drought intensifies. A pre-existing record of mortality after recent drought in Eucalyptus woodland defines the moisture sensitivity of tree species and will be related to their functional traits, population dynamics and geography. This analysis will search for generalised characters that define the species that will be most suscept ....Predicting the consequences of drought-induced mortality for tree species in a changing climate. Tree mortality will be a dramatic manifestation of climate change as drought intensifies. A pre-existing record of mortality after recent drought in Eucalyptus woodland defines the moisture sensitivity of tree species and will be related to their functional traits, population dynamics and geography. This analysis will search for generalised characters that define the species that will be most susceptible to drought and will identify how future exaggerated drought will reorganise forest communities. The findings will contribute to understanding the vulnerability and resilience of our natural ecosystems with a changing climate.Read moreRead less
Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPI ....Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPIs)”. This project plans to couple advanced physiological and functional genomics techniques to transform our understanding of how algal symbiont metabolic KPIs regulate coral growth and stress susceptibility. This may provide new diagnostic capability for the assessment of coral health and may enable us to improve coral reef ecosystem management.Read moreRead less
Hydraulic control on water use, growth and survival in tropical rainforest. This project aims to measure drought-related limits to water transport in the woody xylem tissue of trees in Australian tropical rainforests, to understand how this influences tree water use, photosynthesis, health and mortality risk. Tropical rainforests are sensitive to climate variability, especially drought, but this sensitivity is poorly understood, despite large effects regionally and globally. This project will co ....Hydraulic control on water use, growth and survival in tropical rainforest. This project aims to measure drought-related limits to water transport in the woody xylem tissue of trees in Australian tropical rainforests, to understand how this influences tree water use, photosynthesis, health and mortality risk. Tropical rainforests are sensitive to climate variability, especially drought, but this sensitivity is poorly understood, despite large effects regionally and globally. This project will compare forests that contrast strongly in seasonal drought stress, and use the information to develop a model designed for species-diverse forest, with subsequent potential global application. The understanding gained will enable widely applicable advances designed to feed through rapidly to regional- and global-scale models that inform land use, economic and social policy-making.Read moreRead less