The Analgesic Evaluation Of Novel Natural Products From The Australian Plant Barringtonia Acutangula
Funder
National Health and Medical Research Council
Funding Amount
$174,500.00
Summary
This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that wi ....This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that will allow for their pharmacological evaluation as potential analgesic drugs.Read moreRead less
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
The economics of (mis)information in the age of social media. New media technologies allow anyone to broadcast their views, leading to a “cacophony of voices” where misinformation flourishes. Tools from information economics are tailor-made for understanding information consumption in settings with many biased news sources. We develop economic models where many sources compete to attract and influence heterogenous listeners. We then study how misinformation spreads and amplifies when consumers ....The economics of (mis)information in the age of social media. New media technologies allow anyone to broadcast their views, leading to a “cacophony of voices” where misinformation flourishes. Tools from information economics are tailor-made for understanding information consumption in settings with many biased news sources. We develop economic models where many sources compete to attract and influence heterogenous listeners. We then study how misinformation spreads and amplifies when consumers of information communicate with many others through a social network. Finally, we study how to design simple and robust rules to foster informative discourse and filter misinformation. The results will shape economic policy recommendations for regulating misinformation in media platforms and social media.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101014
Funder
Australian Research Council
Funding Amount
$349,785.00
Summary
Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who ha ....Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who have not. Such preferences are common in many non-market settings and can have dramatic effects on the efficiency of potential mechanisms. The ultimate goal of this project is to develop applied mechanisms that are robust to heterogeneity in such intention-based preferences and which can be used in bilateral exchange, contract design and many other non-market settings.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Using behavioural economic insights to overcome student procrastination. This project aims to study the relations between present-biased time preference, procrastination, and achievement at school, using economic experiments. Investment in human capital generates economic benefits for students, families, employers, and society, but its benefits are realised far into the future. Because of these immediate costs and delayed benefits, behavioural economic theory predicts that students will procrast ....Using behavioural economic insights to overcome student procrastination. This project aims to study the relations between present-biased time preference, procrastination, and achievement at school, using economic experiments. Investment in human capital generates economic benefits for students, families, employers, and society, but its benefits are realised far into the future. Because of these immediate costs and delayed benefits, behavioural economic theory predicts that students will procrastinate. This project will identify the characteristics of students at greatest risk of procrastination, evaluate practical strategies to overcome it, and examine whether it is associated with poorer outcomes. This should help schools and policy makers reduce educational inequalities, and yield long-term benefits over students’ lives.Read moreRead less
Voter behaviour and polarisation: The role of social preferences. This project aims to investigate how peer pressure and other social concerns affect voter participation, vote choice, and political polarisation. It will marry behavioural experimental economics with political economics and make use of complementary experimental methods that will allow for the study of carefully controlled elections, followed by a large-scale real-world test of the results. Expected outcomes include improved under ....Voter behaviour and polarisation: The role of social preferences. This project aims to investigate how peer pressure and other social concerns affect voter participation, vote choice, and political polarisation. It will marry behavioural experimental economics with political economics and make use of complementary experimental methods that will allow for the study of carefully controlled elections, followed by a large-scale real-world test of the results. Expected outcomes include improved understanding of how social media and other social factors, and political institutions such as compulsory voting, distort election representation and outcomes. Major benefits include the ability to advise policies to reduce polarisation and improve political institutions to ensure they reflect true societal preferences.Read moreRead less
Status seeking and economic behaviour. The project will look at the importance of status seeking behaviour for the health system, behavioural experiments, international growth, and labelling. The insights will be useful for optimal redistribution policies, international cooperation, and behavioural research.
Information acquisition and voting behaviour. This project aims to understand citizens’ decisions to acquire information about different policy proposals within a democracy and how such information affects their voting behaviour. Proper democracies rely on the informed participation of their citizens in the political debate and political institutions. The project intends to provide formal theories of information acquisition together with empirical evidence on how voting decisions are shaped by t ....Information acquisition and voting behaviour. This project aims to understand citizens’ decisions to acquire information about different policy proposals within a democracy and how such information affects their voting behaviour. Proper democracies rely on the informed participation of their citizens in the political debate and political institutions. The project intends to provide formal theories of information acquisition together with empirical evidence on how voting decisions are shaped by the quantity and quality of information. Understanding how citizens decide to acquire information would help devise policies to reduce polarisation and improve the quality of the political debate and the democracy.Read moreRead less
Honesty and efficiency in the provision of expert services: doctors and other experts as participants in economic experiments. Experts serve us when we see the doctor, the financial planner or the car mechanic. In all these case the expert can take advantage of his superior knowledge and sell us something we do not need. This research will inform policy makers about the underlying motives of real world experts and allow them to design better institutions.