The Analgesic Evaluation Of Novel Natural Products From The Australian Plant Barringtonia Acutangula
Funder
National Health and Medical Research Council
Funding Amount
$174,500.00
Summary
This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that wi ....This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that will allow for their pharmacological evaluation as potential analgesic drugs.Read moreRead less
Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre wil ....Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre will align highly successful clinical and basic researchers in collaboration with a national network of spine scientists to foster interdisciplinary clinical researcher training, develop new diagnostics and therapeutics, and translate findings to the community. Through clinical research the centre aims to: (i) Advance understanding of physiology and pathophysiology of spinal pain (ii) Translate findings from basic research to clinical practice (iii) Establish coordinated multidisciplinary research to reduce the burden of spinal pain (iv) Predict and prevent the transition from acute to chronic states (v) Train a new generation of transdisciplinary clinical scientists (vi) Rapidly assess new treatment possibilities in pre-clinical studies (vii) Develop innovative technologies for diagnostics and therapeutics (viii) Encourage Australian commercialisation opportunities for new discoveries (ix) Encourage community-user participation in direction of research programs (x) Disseminate new findings and information of evidence-based practice to patients, clinicians, insurers, government and the scientific and wider communityRead moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
The economics of (mis)information in the age of social media. New media technologies allow anyone to broadcast their views, leading to a “cacophony of voices” where misinformation flourishes. Tools from information economics are tailor-made for understanding information consumption in settings with many biased news sources. We develop economic models where many sources compete to attract and influence heterogenous listeners. We then study how misinformation spreads and amplifies when consumers ....The economics of (mis)information in the age of social media. New media technologies allow anyone to broadcast their views, leading to a “cacophony of voices” where misinformation flourishes. Tools from information economics are tailor-made for understanding information consumption in settings with many biased news sources. We develop economic models where many sources compete to attract and influence heterogenous listeners. We then study how misinformation spreads and amplifies when consumers of information communicate with many others through a social network. Finally, we study how to design simple and robust rules to foster informative discourse and filter misinformation. The results will shape economic policy recommendations for regulating misinformation in media platforms and social media.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101014
Funder
Australian Research Council
Funding Amount
$349,785.00
Summary
Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who ha ....Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who have not. Such preferences are common in many non-market settings and can have dramatic effects on the efficiency of potential mechanisms. The ultimate goal of this project is to develop applied mechanisms that are robust to heterogeneity in such intention-based preferences and which can be used in bilateral exchange, contract design and many other non-market settings.Read moreRead less
Using behavioural economic insights to overcome student procrastination. This project aims to study the relations between present-biased time preference, procrastination, and achievement at school, using economic experiments. Investment in human capital generates economic benefits for students, families, employers, and society, but its benefits are realised far into the future. Because of these immediate costs and delayed benefits, behavioural economic theory predicts that students will procrast ....Using behavioural economic insights to overcome student procrastination. This project aims to study the relations between present-biased time preference, procrastination, and achievement at school, using economic experiments. Investment in human capital generates economic benefits for students, families, employers, and society, but its benefits are realised far into the future. Because of these immediate costs and delayed benefits, behavioural economic theory predicts that students will procrastinate. This project will identify the characteristics of students at greatest risk of procrastination, evaluate practical strategies to overcome it, and examine whether it is associated with poorer outcomes. This should help schools and policy makers reduce educational inequalities, and yield long-term benefits over students’ lives.Read moreRead less
Voter behaviour and polarisation: The role of social preferences. This project aims to investigate how peer pressure and other social concerns affect voter participation, vote choice, and political polarisation. It will marry behavioural experimental economics with political economics and make use of complementary experimental methods that will allow for the study of carefully controlled elections, followed by a large-scale real-world test of the results. Expected outcomes include improved under ....Voter behaviour and polarisation: The role of social preferences. This project aims to investigate how peer pressure and other social concerns affect voter participation, vote choice, and political polarisation. It will marry behavioural experimental economics with political economics and make use of complementary experimental methods that will allow for the study of carefully controlled elections, followed by a large-scale real-world test of the results. Expected outcomes include improved understanding of how social media and other social factors, and political institutions such as compulsory voting, distort election representation and outcomes. Major benefits include the ability to advise policies to reduce polarisation and improve political institutions to ensure they reflect true societal preferences.Read moreRead less
Physiotherapist Led Stress Inoculation Intervention Integrated With Exercise For Acute Whiplash Injury
Funder
National Health and Medical Research Council
Funding Amount
$518,960.00
Summary
Physical and mental health outcomes following whiplash injury due to a road traffic crash are poor. Early stress system responses are associated with poor recovery. This study will investigate the effectiveness of a physiotherapist led stress inoculation intervention integrated with currently recommended exercise rehabilitation to improve health outcomes after whiplash injury.
Status seeking and economic behaviour. The project will look at the importance of status seeking behaviour for the health system, behavioural experiments, international growth, and labelling. The insights will be useful for optimal redistribution policies, international cooperation, and behavioural research.
Information acquisition and voting behaviour. This project aims to understand citizens’ decisions to acquire information about different policy proposals within a democracy and how such information affects their voting behaviour. Proper democracies rely on the informed participation of their citizens in the political debate and political institutions. The project intends to provide formal theories of information acquisition together with empirical evidence on how voting decisions are shaped by t ....Information acquisition and voting behaviour. This project aims to understand citizens’ decisions to acquire information about different policy proposals within a democracy and how such information affects their voting behaviour. Proper democracies rely on the informed participation of their citizens in the political debate and political institutions. The project intends to provide formal theories of information acquisition together with empirical evidence on how voting decisions are shaped by the quantity and quality of information. Understanding how citizens decide to acquire information would help devise policies to reduce polarisation and improve the quality of the political debate and the democracy.Read moreRead less