Information Quality in Auctions of Multiple Objects. This project aims at using both theory and laboratory experiments to analyse the formation of prices and the buyers' behaviour at auctions of multiple objects. The study focusses on the comparison of simultaneous auction procedures (in which the objects are sold at once) to sequential auction procedures (in which the objects are sold one after the other) and attention is drawn on the effects of the quality of the buyers' information about the ....Information Quality in Auctions of Multiple Objects. This project aims at using both theory and laboratory experiments to analyse the formation of prices and the buyers' behaviour at auctions of multiple objects. The study focusses on the comparison of simultaneous auction procedures (in which the objects are sold at once) to sequential auction procedures (in which the objects are sold one after the other) and attention is drawn on the effects of the quality of the buyers' information about the assets to be sold on their bidding behaviour and on the seller's revenues. The conduct of laboratory experiments will provide a useful assessment of the theoretical predictions and valuable insights into the effects of buyers' information quality on their bidding behaviour at such markets.Read moreRead less
Effective and efficient corporate tax enforcement. This project uses economic theory and experimental tests in order to inform tax authorities on how to best audit tax receipts from corporations. The project will result in advice on how audit resources should be allocated across firms, if minimising corporate tax evasion and at the same time maximising social welfare are the authority's objective.
Price-Setting Rules and Allocative Efficiency in Oligopolies. This project aims to investigate under which circumstances restrictions on how often firms can change prices increase competition in an oligopoly and bring down prices. For this, we propose the use of laboratory experiments with a novel design followed by field experiments and a real price-data analysis for external validation. This study will result in both the advancement of theory describing how firms compete in dynamic oligopolies ....Price-Setting Rules and Allocative Efficiency in Oligopolies. This project aims to investigate under which circumstances restrictions on how often firms can change prices increase competition in an oligopoly and bring down prices. For this, we propose the use of laboratory experiments with a novel design followed by field experiments and a real price-data analysis for external validation. This study will result in both the advancement of theory describing how firms compete in dynamic oligopolies and practical policy advice on how price setting rules can be used to improve consumer welfare. This project has the potential to generate sizable benefits to Australian consumers, as the resulting policy advice would be applicable to large markets such as those for petrol, groceries and online retail.Read moreRead less
Redesigning Landcare policy to better coordinate across landholders. This project aims to study how landscape-sensitive economic incentives and social norms can be leveraged to enhance the short- and long-term effectiveness of conservation programs. It will yield new knowledge for innovative designs in conservation contracting that is urgently needed to address worsening environmental threats in Australia and worldwide. In collaboration with Nobel laureate Vernon Smith’s team, new methods and pr ....Redesigning Landcare policy to better coordinate across landholders. This project aims to study how landscape-sensitive economic incentives and social norms can be leveraged to enhance the short- and long-term effectiveness of conservation programs. It will yield new knowledge for innovative designs in conservation contracting that is urgently needed to address worsening environmental threats in Australia and worldwide. In collaboration with Nobel laureate Vernon Smith’s team, new methods and protocols will improve our ability to generate better data and better understand how social and incentive mechanisms can constructively interact to facilitate collaborative environmental action. Results will help make the achievement of environmental targets and the use of public funds more cost-effective. Read moreRead less
Detection of infrared-biomarkers for the diagnosis and treatment of canine neoplasia. This research hopes to discover infrared-biomarkers for canine cancers using synchrotron infrared and laser light. Many dog cancers are similar to human cancers so cancerous tissues and cells from dogs make excellent models for human cancer research. This project will provide new insights and technological approaches to cancer diagnosis and treatment.
Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen recepto ....Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen receptor (AR)-targeting therapies in human prostate tumours. The identification and functional assessment of these biomarkers will identify those that can be used as surrogate endpoints in clinical trials, facilitate earlier approval of investigational agents and lead to improved options for therapeutic management of prostate cancer.Read moreRead less
Non-classical steroid signalling through SF-1 responsive genes: a key mechanism in environmental endocrine disruption, cancer, and aging. Endocrine disruption by pervasive manmade chemicals, which mimic natural hormones, and are found in plastics, cosmetics, and fire retardants, is known to cause developmental defects in model organisms and wildlife, with substantial risk also to human health. This risk increases with increasing population density and dependence on water recycling. Current tests ....Non-classical steroid signalling through SF-1 responsive genes: a key mechanism in environmental endocrine disruption, cancer, and aging. Endocrine disruption by pervasive manmade chemicals, which mimic natural hormones, and are found in plastics, cosmetics, and fire retardants, is known to cause developmental defects in model organisms and wildlife, with substantial risk also to human health. This risk increases with increasing population density and dependence on water recycling. Current tests to assess such substances use oversimplified modes of hormone action and grossly underestimate the risk of endocrine disruption. This proposal will yield new knowledge about how such substances act in the body, or on wildlife, and form the basis for new more sensitive methods of environmental monitoring.Read moreRead less
Regulation of tissue morphogenesis in reproductive function and metastatic cancer. Infertility, endocrine and metabolic disorders and reproductive cancers are all increasing medical problems and principal contributors to morbidity and mortality in the Australian community. This research takes the novel approach of investigating the mechanisms of dynamic remodeling in reproductive organs. Novel hormonally controlled mechanisms of tissue remodeling unique to reproductive organs and cancers in ad ....Regulation of tissue morphogenesis in reproductive function and metastatic cancer. Infertility, endocrine and metabolic disorders and reproductive cancers are all increasing medical problems and principal contributors to morbidity and mortality in the Australian community. This research takes the novel approach of investigating the mechanisms of dynamic remodeling in reproductive organs. Novel hormonally controlled mechanisms of tissue remodeling unique to reproductive organs and cancers in adults have been discovered. The results are being applied to new medical alternatives for infertile patients and new diagnostics and therapeutics for patients with metastatic cancers. The information is also being applied to improve reproductive efficiency in animal production industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668241
Funder
Australian Research Council
Funding Amount
$824,610.00
Summary
A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflamma ....A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which new therapies may be developed. This endeavour will contribute to national research priorities in both the health and scientific/technological development arenas.Read moreRead less
Molecular dynamics of steroid receptor crosstalk. This project uses state-of-the-art technology to show how steroids (for example, testosterone) affect many aspects of human life, and how these can be disrupted by chemicals and synthetic hormones. The results can be used to interpret disease, predict safety of new drugs, and to monitor risk to humans and wildlife of environmental chemicals.