Market Design for the Reallocation of Land. This fellowship uses laboratory and lab-in-the-field experiments to explores how market design can be used to develop combinatorial exchanges that allow participants to exchange packages of land. Allowing for package bids can facilitate trade in situations where owning one piece of land increases the value of adjacent land and where assembling contiguous pieces of land is important. Combinatorial exchanges have the potential to increase the productivit ....Market Design for the Reallocation of Land. This fellowship uses laboratory and lab-in-the-field experiments to explores how market design can be used to develop combinatorial exchanges that allow participants to exchange packages of land. Allowing for package bids can facilitate trade in situations where owning one piece of land increases the value of adjacent land and where assembling contiguous pieces of land is important. Combinatorial exchanges have the potential to increase the productivity of agriculture land in both Australia and developing countries, encourage urban redevelopment, and help the government secure land for infrastructure and environmental protection in a cost-effective way.Read moreRead less
Identification of novel therapeutic targets for selectively eliminating cancer stem cells in paediatric leukaemia. Leukaemia is the most common form of cancer in children, and while the majority of children can be cured, those who relapse face a dire prognosis. It is widely believed that leukemic stem cells are responsible for relapse and this project will aim to unravel their underlying biology and identify new targets for therapeutic approaches to the disease.
mTOR signalling in serous ovarian cancer. Serous ovarian cancer is the most aggressive and lethal gynaecological cancer in Australian women. Activation of Mammalian Target of Rapamycin (mTOR) is frequently observed and associated with poor prognosis in ovarian cancer patients. However, the mechanisms dysregulating mTOR in the pathogenesis of ovarian cancer are unknown. In preliminary studies, deletion of genes regulating mTOR signalling in up to 60 per cent of human serous ovarian cancer patien ....mTOR signalling in serous ovarian cancer. Serous ovarian cancer is the most aggressive and lethal gynaecological cancer in Australian women. Activation of Mammalian Target of Rapamycin (mTOR) is frequently observed and associated with poor prognosis in ovarian cancer patients. However, the mechanisms dysregulating mTOR in the pathogenesis of ovarian cancer are unknown. In preliminary studies, deletion of genes regulating mTOR signalling in up to 60 per cent of human serous ovarian cancer patients was observed. This project will provide mechanistic details of involvement of mTOR signalling in pathogenesis of the serous ovarian carcinoma, and develop a rationale for targeting mTOR pathway in these patients. Read moreRead less
Studying precancerous stem cells that cause T cell leukaemia. Recent research has identified abnormal stem cells that are the cause of T cell leukaemia. They are also resistant to therapeutics suggesting that they could be a cause of relapse. The aim of this project is to determine the abnormal pathways that cause these cells to become immortal and to determine new therapeutic strategies to eliminate them.
Unraveling the genetic networks of cancer development. Cancer causes nearly 30% of all deaths in Australia and the aging of our population means that its incidence will increase for the foreseeable future. The past two decades of cancer research have yielded great advances in identifying the genetic mutations that contribute to cancer, but our understanding of how these mutations cooperate to transform a healthy cell into a tumour cell remains limited. High-throughput genomic analysis of DNA fro ....Unraveling the genetic networks of cancer development. Cancer causes nearly 30% of all deaths in Australia and the aging of our population means that its incidence will increase for the foreseeable future. The past two decades of cancer research have yielded great advances in identifying the genetic mutations that contribute to cancer, but our understanding of how these mutations cooperate to transform a healthy cell into a tumour cell remains limited. High-throughput genomic analysis of DNA from large numbers of tumours is essential to identify and understand the combinations of cancer mutations that are most deadly. Such studies can form the basis for developing better diagnostics and new treatments for patients whose tumours are resistant to current therapies.Read moreRead less
Rethinking diversity and inclusion practices in leadership roles. This project aims to study the lack of racial and gender diversity in management and leadership roles. The noticeable imbalances question the functioning of the meritocracy principle and may lead to organisational and social vulnerabilities. This project will apply large-scale field experiments with major organisations to investigate how workplace diversity and inclusion can be improved using as foundation economic theories of sig ....Rethinking diversity and inclusion practices in leadership roles. This project aims to study the lack of racial and gender diversity in management and leadership roles. The noticeable imbalances question the functioning of the meritocracy principle and may lead to organisational and social vulnerabilities. This project will apply large-scale field experiments with major organisations to investigate how workplace diversity and inclusion can be improved using as foundation economic theories of signaling, discrimination, fairness, and identity. The expected outcome is the identification of best diversity and inclusion practice in attraction, hiring, development and retention. This will provide significant benefit through an increase in workplace diversity.
Read moreRead less
Psychosocial intervention to improve psychological and quality of life outcomes after cancer. Chronic diseases such as cancer have long-term negative effects on the quality of life of not only patients but also their carers. This project will develop effective ways to support individuals and carers to achieve optimal psychological and quality of life outcomes in the face of serious illness.
Inherited determinants of cancer aetiology. Family history of cancer is a strong risk factor for many cancers. This project will aim to identify inherited factors influencing risk of developing cancer and those factors influencing the course of the disease and outcomes.
The role of moral sentiments and emotions in human nature: an interdisciplinary empirical approach. This project investigates the effects of moral sentiments and emotions on decision processes. It will identify states of physiological arousal, determine whether a significant genetic effect is present, assess the relevance of individuals' environment and inherited values, and provide a better biological micro-foundation for human behaviour.
The critical role of the class III histone deacetylase SIRT2 in stabilizing N-Myc oncoprotein. Cancer is the commonest cause of death from disease in children. Neuroblastoma is the commonest solid tumor in early childhood. This project will investigate the critical roles of SIRT2 protein in increasing the expression of N-Myc oncoprotein and consequently inducing neuroblastoma, and SIRT2 inhibitors as anticancer agents.