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Research Topic : experimental diabetes
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  • Funded Activity

    Analysis Of Effect Of Different Treatment Targets On Maternal And Child Health Outcomes In Gestational Diabetes Mellitus (GDM), Review Of Specific Treatments And Development Of Clinical And Biochemical Predictors.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $122,686.00
    Summary
    This research aims to analyse newly proposed treatment targets for Gestational Diabetes Mellitus (GDM) and the effect this will have on maternal and child health outcomes, via comparison of data from two large Australian health services using the traditional and newly proposed critiera. The research will also investigate current effective interventions for GDM, including the impact of early antenatal lifestyle interventions, and formulation of a clinical and biochemical risk prediction model.
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    Funded Activity

    Type 1 Diabetes And The Metabolic Syndrome: Defining This Modern-day Phenotype, And Exploring The Effects Of Exercise On Glycaemic Control And Both Traditional And Novel Diabetes Complications

    Funder
    National Health and Medical Research Council
    Funding Amount
    $122,714.00
    Summary
    This research aims to define trends in the prevalence of, and complications associated with, metabolic syndrome in adults with type 1 diabetes, using the Australian National Diabetes Information Audit and Benchmarking Initiative (ANDIAB). Subsequently, a randomised controlled trial will examine the effect of exercise on glycaemic control and diabetes complications risk profiles in this group. These studies will thus address disease profiles and a potential beneficial clinical intervention.
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    Funded Activity

    Heterogeneity Of Gestational Diabetes

    Funder
    National Health and Medical Research Council
    Funding Amount
    $118,704.00
    Summary
    Gestational diabetes is an important medical condition. We plan to investigate two subgroups of women with gestational diabetes. Firstly, women who have diabetes antibodies in pregnancy. Secondly, women who have a mild form of diabetes caused by a single gene mutation, who may be first identified during pregnancy. Correct identification of these subgroups of women is important for immediate and long-term management of both the mother and her fetus.
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    Funded Activity

    Maximising The Population Impact Of Digital Self-management Programs To Improve Type 2 Diabetes Outcomes

    Funder
    National Health and Medical Research Council
    Funding Amount
    $64,713.00
    Summary
    My PhD research will determine how user engagement with a digital diabetes program improves sustained diabetes outcomes and which program features contribute most to this improvement within disadvantaged people with diabetes. In addition to ensuring that such programs are equitable and optimise health gains of all Australians with T2DM, findings from my research will also help realise the potential of this technology to be used to address other chronic illness management.
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    Funded Activity

    Diabetes And Cardiovascular Risk Among Indigenous Women After Pregnancy Complicated By Hyperglycaemia.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $128,224.00
    Summary
    Indigenous Australian women are at high risk of having GDM which increases the risk of developing both GDM in future pregnancies and T2DM. We want to clarify these risks and whether there are differences between Indigenous and non-Indigenous women. Ideally, we can intervene to prevent this cycle of disease as diabetes in pregnancy has long term poor health outcomes for both mothers and their offspring.
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    Funded Activity

    Analysis Of Proinsulin-epitope Specific CD4+ T Cells In Blood Of People With Type 1 Diabetes

    Funder
    National Health and Medical Research Council
    Funding Amount
    $122,834.00
    Summary
    Type 1 diabetes (T1D) is an incurable autoimmune disease characterised by T-cell mediated destruction of insulin-secreting cells of the pancreas. Development of preventative therapies is hampered by paucity of knowledge regarding the targets of the autoimmune T-cell response. We have recently identified epitopes ‘seen’ by islet-infiltrating T-cells, located in proinsulin. Our aim is to examine proinsulin-specific T-cell responses in the peripheral blood of people with and without T1D.
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    Funded Activity

    Birth Outcomes And Body Composition In Babies Born To Mothers With Diabetes In Pregnancy

    Funder
    National Health and Medical Research Council
    Funding Amount
    $109,358.00
    Summary
    This study will evaluate outcomes and body composition in neonates born to mothers who have diabetes during their pregnancy in the Northern Territory. Babies born to mothers with diabetes may be at higher risk of complications during birth and later in life may have increased risk of obesity and diabetes, conditions which are particularly prevalent in the Indigenous population and contribute to high morbidity and mortality rates. This study will be important to evaluate these factors, particular .... This study will evaluate outcomes and body composition in neonates born to mothers who have diabetes during their pregnancy in the Northern Territory. Babies born to mothers with diabetes may be at higher risk of complications during birth and later in life may have increased risk of obesity and diabetes, conditions which are particularly prevalent in the Indigenous population and contribute to high morbidity and mortality rates. This study will be important to evaluate these factors, particularly in a high risk population.
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    Funded Activity

    Closed-loop Insulin Delivery Compared With Islet Cell Transplantation For Adults With Type 1 Diabetes And Impaired Awareness Of Hypoglycaemia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $92,745.00
    Summary
    Hypoglycaemia in adults with type 1 diabetes is common. Evaluation of therapies – the ‘artificial pancreas’ and islet cell transplantation - is warranted in a cohort with repeated episodes of hypoglycaemia. This proposal will assess whether the ‘artificial pancreas’ and islet cell transplantation, compared with usual insulin therapy, will reduce hypoglycaemia and improve other clinical outcomes over 6 months. This has potential to expand therapies used in current clinical practice.
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    Funded Activity

    Determinants Of Glycemic Control In Australian Children With Type 1 Diabetes- A National Population Based Study.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $90,524.00
    Summary
    The aim of the study is to examine the influence of practices and therapies used in Australian youth with Type 1 Diabetes and the clinical and demographic predictors of blood glucose control. Optimized blood glucose control reduces the risk of progression to kidney disease, vision impairment and cardiovascular disease. This study will provide insight into the influences on blood glucose control, including those that are modifiable. This will provide an evidence base to inform clinical practice.
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    Funded Activity

    Maternal Lipids In Pregnancy

    Funder
    National Health and Medical Research Council
    Funding Amount
    $99,359.00
    Summary
    There is a link between maternal lipids and newborn weight as well as other adverse pregnancy outcomes. Maternal lipids _ serum level, dietary intake and change in maternal lipids during pregnancy may be important in determining not only immediate pregnancy and newborn outcomes but also longer term problems for mother and child. As yet, we do not know whether altering maternal lipids will change outcomes or how to influence lipid levels in practice or how best to approach this.
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