Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliv ....Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliver the knowledge to underpin effective psychological safety and mental health guidelines for community sports with national impact. When implemented, this knowledge will help sports clubs to provide a psychologically safe environment, and promote the mental health and wellbeing of all Australians involved in organised sports.Read moreRead less
Regulatory mechanisms in skeletal muscle lipid hydrolysis. The regulation of intramuscular triglyceride (fat) utilisation by human skeletal muscle is largely unknown. Our contention is that the specialized protein enzyme, hormone sensitive lipase (HSL), has a fundamental role in intramuscular triacylglycerol utilisation and is regulated by both intramuscular levels of key metabolites and circulating hormone concentrations. We also propose control points subsequent to HSL activation are important ....Regulatory mechanisms in skeletal muscle lipid hydrolysis. The regulation of intramuscular triglyceride (fat) utilisation by human skeletal muscle is largely unknown. Our contention is that the specialized protein enzyme, hormone sensitive lipase (HSL), has a fundamental role in intramuscular triacylglycerol utilisation and is regulated by both intramuscular levels of key metabolites and circulating hormone concentrations. We also propose control points subsequent to HSL activation are important for triglyceride hydrolysis. Our proposed project examines these factors and will enhance our understanding of the regulation of muscle fat use, thereby leading to potential metabolic strategies (nutritional, pharmacological) that enhance skeletal muscle function at rest and during exercise.Read moreRead less
Biological Role of Contraction-Induced Heat Shock Protein Expression. It is well known that mammalian skeletal muscle increases its expression of a group of highly conserved proteins, the heat shock proteins (HSP) in response to repeated contraction. However, the biological role of this expression is unclear. The aim of this project is to determine the biological role of contraction-induced HSP expression. We expect to show that HSP synthesis in response to exercise has three major roles; 1) to ....Biological Role of Contraction-Induced Heat Shock Protein Expression. It is well known that mammalian skeletal muscle increases its expression of a group of highly conserved proteins, the heat shock proteins (HSP) in response to repeated contraction. However, the biological role of this expression is unclear. The aim of this project is to determine the biological role of contraction-induced HSP expression. We expect to show that HSP synthesis in response to exercise has three major roles; 1) to act to repair damaged proteins in recovery from muscle injury 2) to act as a "molecular motor" to translocate proteins from one region of a muscle cell to another and 3) to be released into the circulation in order to act as a central signal to activate immune cells. Such a project will be significant because it will allow for a fundamental understanding as to why these proteins are produced in response to exercise. We expect to enhance our understanding of fundamental cell biology.Read moreRead less
Reducing the fat burden: Identification of novel cellular and molecular targets for alleviating skeletal muscle insulin resistance. Insulin resistance and the associated consequences are a major public health problem in Australia and cost the healthcare system >$1.1 billion/year. Exercise training and thiaziolidinedione (TZD) treatment are therapies that partially ameliorate insulin resistance through distinct and independent mechanisms. However, neither intervention represents a viable long-ter ....Reducing the fat burden: Identification of novel cellular and molecular targets for alleviating skeletal muscle insulin resistance. Insulin resistance and the associated consequences are a major public health problem in Australia and cost the healthcare system >$1.1 billion/year. Exercise training and thiaziolidinedione (TZD) treatment are therapies that partially ameliorate insulin resistance through distinct and independent mechanisms. However, neither intervention represents a viable long-term strategy: exercise training has low compliance, while chronic TZD use is associated with several adverse side effects (edema, weight gain etc.). We will investigate the metabolic, cellular and molecular mechanisms by which these therapies each exert their positive effect on insulin action with the aim of identifying novel targets for future drug interventions. Read moreRead less
Intracellular localisation of insulin signalling proteins in human skeletal muscle following exercise. The metabolic action of insulin in skeletal muscle is enhanced by exercise, but the underlying mechanisms mediating this are unknown. Insulin receptor substrate proteins are key mediators in the intracellular insulin signalling pathway and play a central role in regulating many metabolic events. Our aim is to examine the hypothesis that exercise induces a novel subcellular redistribution of the ....Intracellular localisation of insulin signalling proteins in human skeletal muscle following exercise. The metabolic action of insulin in skeletal muscle is enhanced by exercise, but the underlying mechanisms mediating this are unknown. Insulin receptor substrate proteins are key mediators in the intracellular insulin signalling pathway and play a central role in regulating many metabolic events. Our aim is to examine the hypothesis that exercise induces a novel subcellular redistribution of these insulin receptor substrate proteins in skeletal muscle, such that the metabolic action of insulin is enhanced. Elucidating the mechanisms whereby exercise enhances insulin action underpins the development of new treatments and therapies with the aim of improving skeletal muscle function in health and disease.Read moreRead less
Crucibles of creativity? Australian universities and path-breaking intellectual work. The project will investigate path-breaking creative work by 60-80 Australians working at home and abroad, focusing on the role of Australian universities in forming creative persons and agendas and providing conditions for (or inhibiting) creativity. The practical question is ‘How might the role of universities in path-breaking work be enhanced?'
National and global public goods in higher education. This project will compare case studies in Australia, the United Kingdom, central Europe and China to clarify the definition, measurement and creation of public (social and community) benefits in higher education, including global benefits. It will inform government policies and institutional and philanthropic strategies designed to maximise those public benefits.
Adult Numeracy and New Learning Technologies: An Evaluative Framework. In the adoption of new learning technologies [NLTs] (e.g., online, CD-ROMS) as alternative means of delivery for adult numeracy, high quality educational products, informed by a well-founded research base, are essential to benefit the individual student, and tutors/trainers (if any). Given that concept of adult numeracy itself is ill-defined and under-theorised in Australia, and that there are no entry standards for numeracy ....Adult Numeracy and New Learning Technologies: An Evaluative Framework. In the adoption of new learning technologies [NLTs] (e.g., online, CD-ROMS) as alternative means of delivery for adult numeracy, high quality educational products, informed by a well-founded research base, are essential to benefit the individual student, and tutors/trainers (if any). Given that concept of adult numeracy itself is ill-defined and under-theorised in Australia, and that there are no entry standards for numeracy tutors/trainers, or even producers of resources, research is needed to establish a defensible definition of adult numeracy in the Australian context, and to synthesise this with evolving research on NLTs to guide producers and enable proper consumer evaluation.Read moreRead less
Leadership in entrepreneurial universities: cross-national investigations of engagement and diversity. Attracting and retaining academics in leadership is critical to developing twenty-first century universities that promote innovative and creative economies and inclusive civil societies. This comparative study will provide policy makers and universities with empirical evidence and policy options to build leadership capacity and increase diversity in leadership.
Elite independent schools in globalising circumstances: a multi-sited global ethnography. This is a study of elite independent schools in Australia, New Zealand, Singapore, Hong Kong, Malaysia, India, Barbados, South Africa, the USA and England. Because such schools are often seen as the gold standard for school education, and because their alumni are often highly influential in economic, political and professional circles, understanding what they do and the ideals they stand for is important na ....Elite independent schools in globalising circumstances: a multi-sited global ethnography. This is a study of elite independent schools in Australia, New Zealand, Singapore, Hong Kong, Malaysia, India, Barbados, South Africa, the USA and England. Because such schools are often seen as the gold standard for school education, and because their alumni are often highly influential in economic, political and professional circles, understanding what they do and the ideals they stand for is important nationally and globally. This study will identify the impact of increased global connections on such schools and will enhance understanding of how many national and international leaders are formed through their education and with what possible implications. Read moreRead less