Optimising Exercise and Nutrition Throughout the Life Cycle. During the past decade the proportion of Australia's population aged 65 years and over has increased to 13% (2.7 million). During the same period, the proportion of the population aged 85 years and over has more than doubled and is now the fastest growing subpopulation in Australia. As the number of elderly persons continues to grow, sarcopenia-related conditions will have a dramatic and inevitable impact on the lives of all Australian ....Optimising Exercise and Nutrition Throughout the Life Cycle. During the past decade the proportion of Australia's population aged 65 years and over has increased to 13% (2.7 million). During the same period, the proportion of the population aged 85 years and over has more than doubled and is now the fastest growing subpopulation in Australia. As the number of elderly persons continues to grow, sarcopenia-related conditions will have a dramatic and inevitable impact on the lives of all Australians. The novel dietary protocols developed from the results of the studies undertaken in this proposal will translate into better treatment options for reversing age-dependent muscle degeneration. This is a critical first step for improving the standard of living for a large portion of Australian society.Read moreRead less
Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self- ....Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self-efficacy and impact on positive PA behaviours. Long-term, behavioural change and job-related outcomes will be evaluated by following participants for 12 months after the interventions.Read moreRead less
Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and aga ....Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and again make Australian TID the international benchmark. Results will highlight the role of TID practices in improving recreational participation and maximising, attracting, developing and retaining sport talent. This will result in improved use of sports limited TID funding by providing greater understanding of factors that influence elite selection and sport development.Read moreRead less
Relaxin: molecular mechanisms of action in the reversal of fibrosis. Defects in relaxin and relaxin receptors are increasingly implicated as a cause of fibrosis which is associated with many disease processes. This study will examine the molecular mechanisms linking relaxin and fibrosis and will determine whether relaxin can be used to reverse the condition.
Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action ....Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action in these organs. Our findings will provide important basic information on relaxin physiology and enable us to implement a long-term partnership with Connetics to understand how relaxin regulates collagen production and/or the development of fibrosis.Read moreRead less
The efficacy of a referral and physical activity program for survivors of prostate cancer. Although survival rates of prostate cancer are approximately 83 per cent with earlier detection and improved treatment modalities, prostate cancer survivors are at an increased risk of dying from co-morbidities, which may be prevented or ameliorated through participation in physical activity. This project aims to establish an effective and sustainable referral and physical activity program to improve the ....The efficacy of a referral and physical activity program for survivors of prostate cancer. Although survival rates of prostate cancer are approximately 83 per cent with earlier detection and improved treatment modalities, prostate cancer survivors are at an increased risk of dying from co-morbidities, which may be prevented or ameliorated through participation in physical activity. This project aims to establish an effective and sustainable referral and physical activity program to improve the health outcomes of prostate cancer survivors by utilising the influence of clinicians in their delivery of information to patients. This concept of a referral and physical activity program has the potential to translate across all cancer tumour streams to reduce the physiological and psychological burden associated with living with cancer.Read moreRead less
Novel anti-ageing peptides in the vascular system. The project will substantially improve basic understanding of the ageing process in blood vessels and provide scientific evidence to understand what preventative health care measures might work and why. It will also produce highly skilled and practically trained graduates, ready to contribute to the health industry.
Investigation of the function of Sel S a novel selenoprotein. The long term aim of this project is to find a way to prevent or delay the onset of both Type 1 and Type 2 diabetes. ChemGenex pharmaceuticals, our commercial partners have discovered and patented a selenoprotein with antioxidant properties and have shown in vitro that it protects insulin-producing beta cells from oxidative damage. This project aims to prove, in an in vivo setting, that this protein can prevent or delay the onset of d ....Investigation of the function of Sel S a novel selenoprotein. The long term aim of this project is to find a way to prevent or delay the onset of both Type 1 and Type 2 diabetes. ChemGenex pharmaceuticals, our commercial partners have discovered and patented a selenoprotein with antioxidant properties and have shown in vitro that it protects insulin-producing beta cells from oxidative damage. This project aims to prove, in an in vivo setting, that this protein can prevent or delay the onset of diabetes in mouse models of type 1 and Type 2 diabetes.Read moreRead less
The psychological effects of wasting in Australian jockeys. It is well known that many jockeys engage in short-term, unhealthy cycles of weight loss and gain, known as 'wasting', to maintain consistent low riding-weight. The use of saunas is specially popular, with other known practices including food avoidance, laxative abuse, ingestion of diuretics and appetite suppressants, excessive exercise and self-induced vomiting. The adverse physiological effects of 'wasting' are well documented. This i ....The psychological effects of wasting in Australian jockeys. It is well known that many jockeys engage in short-term, unhealthy cycles of weight loss and gain, known as 'wasting', to maintain consistent low riding-weight. The use of saunas is specially popular, with other known practices including food avoidance, laxative abuse, ingestion of diuretics and appetite suppressants, excessive exercise and self-induced vomiting. The adverse physiological effects of 'wasting' are well documented. This investigation seeks to explore and describe the ways in which these pathogenic forms of weight control used the jockeys effect their psychological health. The primary outcome focus of the research is the formulation of recommendations for the adoption of healthy weight management practices by Australian jockeys that promote psychological well-being.Read moreRead less
The adoption and maintenance of physical activity in 25-45 year old sedentary females. This research project will investigate interventions based on proven elements of theories on the adoption and maintenance of increased physical activity and psychological well-being in sedentary women aged 25-45 years, who are at risk of remaining inactive. A longitudinal study will examine the efficacy of adoption and maintenance interventions that combine effective constructs identified in analysis of theori ....The adoption and maintenance of physical activity in 25-45 year old sedentary females. This research project will investigate interventions based on proven elements of theories on the adoption and maintenance of increased physical activity and psychological well-being in sedentary women aged 25-45 years, who are at risk of remaining inactive. A longitudinal study will examine the efficacy of adoption and maintenance interventions that combine effective constructs identified in analysis of theories. Effective intervention will promote current life-experience, healthy lifestyle in later life, and decrease risk of chronic ill health.Read moreRead less