Randomized Controlled Trial Of CPAP On Cardiac Function In Patients With Heart Failure And Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$140,906.00
Summary
Heart failure is a very common condition associated with disabling symptoms. The main symptoms are breathlessness, usually during sleep or upon exercise, and fatigue. Recent research has identified that sleep apnoea, a condition that occurs in about 50% of subjects with heart failure, is likely to be responsible for these symptoms. Moreover, treatment specifically aimed at sleep apnoea, namely continuous positive airway pressure (CPAP) delived via a small electric pump and nasal mask worn during ....Heart failure is a very common condition associated with disabling symptoms. The main symptoms are breathlessness, usually during sleep or upon exercise, and fatigue. Recent research has identified that sleep apnoea, a condition that occurs in about 50% of subjects with heart failure, is likely to be responsible for these symptoms. Moreover, treatment specifically aimed at sleep apnoea, namely continuous positive airway pressure (CPAP) delived via a small electric pump and nasal mask worn during sleep, may also improve the symptoms of heart failure. The study will involve subjects with stable heart failure on optimal drug treatment who have evidence of obstructive sleep apnea on an overnight sleep study. Obstructive sleep apnoea (OSA) is a condition in which the throat intermittently narrows or blocks during sleep (often associated with snoring) causing cessation of airflow or apnoeas. Associated with the apnoeas are vigorous efforts by the chest muscles to breathe (creating negative vacuum-like pressures within the chest - and around the heart) at a time of falling oxygen levels. Previous research has suggested that these obstructive apnoeas are detrimental to the heart. Volunteers will be randomized to either a control or a CPAP treated group for a three month period. The control and CPAP groups will receive intensive advice about good eating and sleeping habits as weight gain and sleep loss are factors known to aggravate heart failure and obstructive sleep apnoea. In addition to the lifestyle advice, the CPAP group will also be treated with nasal CPAP. The variables which we will measure include severity of sleep apnoea, exercise capacity, heart function at rest and symptoms. Symptoms will be measured using 4 very detailed and validated questionnaires.Read moreRead less
Improving Functional Capacity In Patients With Chronic Lung Disease With High Intensity Respiratory Muscle Training
Funder
National Health and Medical Research Council
Funding Amount
$340,880.00
Summary
Patients with chronic respiratory disease have limited exercise capacity, which severely impairs their quality of life. The mechanisms responsible for this impairment may relate to their lung disease, or to the long-term effects that inactivity has on the cardiovascular and musculoskeletal systems. Pulmonary rehabilitation programs involving whole-body exercise are now widely used as an addition to standard medical therapy as a way of decreasing symptoms and optimising function. While these gene ....Patients with chronic respiratory disease have limited exercise capacity, which severely impairs their quality of life. The mechanisms responsible for this impairment may relate to their lung disease, or to the long-term effects that inactivity has on the cardiovascular and musculoskeletal systems. Pulmonary rehabilitation programs involving whole-body exercise are now widely used as an addition to standard medical therapy as a way of decreasing symptoms and optimising function. While these generalised, broad-based programs result in modest improvements in peripheral muscle function, cardiovascular function, functional exercise capacity and quality of life, it is now apparent they have little or no effect on respiratory muscle function, which is also greatly impaired in COPD. The aims of this study are to answer two longstanding questions that are fundamental to rehabilitation programs in patients with COPD (i) does a program of specific respiratory muscle training alone improve whole-body exercise capacity, dyspnoea, and-or quality of life? and (ii) does the addition of a program of specific respiratory muscle training to a standard whole-body exercise rehabilitation program result in improvemed exercise capacity, dyspnoea and-or quality of life to a greater degree than a program of whole-body exercise training alone? The study is of importance to patients with COPD by investigating the mechanisms underlying the improvement in exercise capacity following a rehabilitation program and the role of respiratory muscle training in such a program. By more accurately defining the mechanisms of exercise limitation we may be able to maximise the benefits obtained during a rehabilitation program, including improved work capacity, reduction in the degree of breathlessness and improved quality of life.Read moreRead less
Developing Capability And Improve Access To Chairperson Capacity In Fishing And Aquaculture (bursary)
Funder
Fisheries Research and Development Corporation
Funding Amount
$2,799.00
Summary
This course, 'The Role of the Chair' is presented by the Australian Institute of Company Directors, and as such is a well recognised and regarded training body. The course itself explores the unique leadership responsibilities, including their relationships with other board members and the CEO that the Chair person's position has. It is a one day course held in Sydney, and requires pre-study and follow up review work.
The course offers a rare opportunity to discreetly discuss leadershi ....This course, 'The Role of the Chair' is presented by the Australian Institute of Company Directors, and as such is a well recognised and regarded training body. The course itself explores the unique leadership responsibilities, including their relationships with other board members and the CEO that the Chair person's position has. It is a one day course held in Sydney, and requires pre-study and follow up review work.
The course offers a rare opportunity to discreetly discuss leadership and governance issues – including board selection, boardroom processes and CEO succession planning – with fellow chairs and experienced directors.
The benefit to the FRDC and to the industry is the improved skills and capabilities of Kate Brooks, most immediately in her role as Chairperson for the FRDC C&C Steering Committee, but also other Chairperson roles she may step up to such as those with OzFish Unlimited, or the SA Government, as the most immediate possibilities. Objectives: 1. Undertake the Role of the Chair, Australian Institute of Company Directors (AICD) course 2. Participant obtains a greater understanding of Chair’s leadership role and key governance responsibilities Read moreRead less
Does Manipulation Of Arterial Shear Stress Enhance Cerebrovascular Function And Cognition In The Aging Brain?
Funder
National Health and Medical Research Council
Funding Amount
$707,914.00
Summary
Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating ....Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating disease in Australians.Read moreRead less
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Australian Rural Leadership Foundation 30th Anniversary Sponsorship - Silver Package
Funder
Fisheries Research and Development Corporation
Funding Amount
$5,000.00
Summary
Silver Sponsorship Package Benefits: - Acknowledgement in the promotion of the Australian Rural Leadership Foundation 30th Anniversary Celebration. - Opportunities to engage with the ARLF broader network through events, activities, media and communications. - Your organisation’s logo and link on the Australian Rural Leadership Foundation website, included in relevant social media posts and the ARLF newsletter. - Onsite signage and recognition (where applicable). - The right f ....Silver Sponsorship Package Benefits: - Acknowledgement in the promotion of the Australian Rural Leadership Foundation 30th Anniversary Celebration. - Opportunities to engage with the ARLF broader network through events, activities, media and communications. - Your organisation’s logo and link on the Australian Rural Leadership Foundation website, included in relevant social media posts and the ARLF newsletter. - Onsite signage and recognition (where applicable). - The right for you to use the ARLF 30th Anniversary brand and logo on relevant promotional material. - The right to use “Silver Partner of the Australian Rural Leadership Foundation 30th Anniversary Celebration”, your organisation referred as such in all relevant collateral and social media content and use of the ARLF 30th Anniversary brand and logo on promotional printed and digital material. - Six (6) tickets to the 30th Anniversary Gala Dinner - 26 October 2022 Objectives: 1. Recognise and celebrate leadership capability and capacity in fishing and aquaculture Read moreRead less
Asparagopsis R&D Review And Implementation Plan For A National Seaweed Hatchery Network
Funder
Fisheries Research and Development Corporation
Funding Amount
$103,930.00
Summary
The project provides support for ASSA to undertake preparation activities in advance of receiving an $8.0m grant from the Federal government (late May/early June 2023). The duration of the grant is approximately 2 years and includes $6.18 million expenditure aligned to the NHN. Given the tight time frames for what is expected to be a relatively complex capital and human resource intensive NHN build, the earlier the consultation and planning phase can be completed the better. Currently there are ....The project provides support for ASSA to undertake preparation activities in advance of receiving an $8.0m grant from the Federal government (late May/early June 2023). The duration of the grant is approximately 2 years and includes $6.18 million expenditure aligned to the NHN. Given the tight time frames for what is expected to be a relatively complex capital and human resource intensive NHN build, the earlier the consultation and planning phase can be completed the better. Currently there are a number of public and private research organisations conducting research on Asparagopsis aquaculture and the application of Asparagopsis derived products for methane reduction. In order to maximise the industry development impact of grant funding may have, it is imperative that the current research initiatives are compiled and reviewed to identify potential information and opportunity gaps prior to the grant being issued. Engaging a SME to review Asparagopsis R&D and provide expert consultation on the conceptualisation and NHN will improve the prospects for the eligible grant activities to be achieved within the stipulated grant duration (until 31 March 2025).
Objectives: 1. Review Asparagopsis R&D across the supply chain from production to application 2. Develop a plan that details investments in the ASSA National Hatchery Network until 31 March 2025 Read moreRead less