Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Open(ing up) goals in physical activity: What works, when, and for whom? This project aims to advance knowledge of open goals as a new goal-setting approach to optimise the adoption and maintenance of physical activity among insufficiently active individuals. This project expects to generate substantive insights into the mechanisms that explain why, when, and for whom open goals are particularly beneficial in this population. Expected outcomes include a theory of open goals that will inform phys ....Open(ing up) goals in physical activity: What works, when, and for whom? This project aims to advance knowledge of open goals as a new goal-setting approach to optimise the adoption and maintenance of physical activity among insufficiently active individuals. This project expects to generate substantive insights into the mechanisms that explain why, when, and for whom open goals are particularly beneficial in this population. Expected outcomes include a theory of open goals that will inform physical activity promotion efforts, with the potential for broad population-level dissemination and scale-up. Significant benefits include the ability to set physical activity goals that are enjoyable and intrinsically motivating to pursue, while also avoiding detrimental effects of current practice (eg high failure rates).Read moreRead less
Understanding The Metabolic Consequences Of Impaired AMPKa2 And NNOS� In Skeletal Muscle: Implications For The Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$575,527.00
Summary
The inability of muscle to utilise sugar from the blood is a major problem that contributes to obesity and Type 2 diabetes. Since the number of people with these diseases will at least double by 2030, we need to find out what causes this problem. We will examine whether two muscle proteins that are impaired in obesity and Type 2 diabetes are also responsible for impaired sugar utilisation. We think that increasing these muscle proteins will fix the _sugar problem�, and remedy these diseases.
Uncovering Sex Specific, Epigenetic Biomarkers Of Healthy Ageing For Targeted Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
The aged population accounts for a significant, and increasing, amount of Australia’s health budget. We aim to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. We will use innovative DNA and protein analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This will underpin the development of evidence-based biomarkers to be used in personalised health interventions.
Use of heart rate kinetics during the rest-exercise transition for tracking changes in exercise performance in athletes. The project aims to develop an objective method for assessing fatigue and recovery in athletes during changes in training load. It is intended that this will inform training adjustments to optimise performance and reduce the risk of overtraining and injury. The method assesses the maximal rate of heart rate increase at the start of light exercise (rHRI), and has been shown in ....Use of heart rate kinetics during the rest-exercise transition for tracking changes in exercise performance in athletes. The project aims to develop an objective method for assessing fatigue and recovery in athletes during changes in training load. It is intended that this will inform training adjustments to optimise performance and reduce the risk of overtraining and injury. The method assesses the maximal rate of heart rate increase at the start of light exercise (rHRI), and has been shown in the project team’s early studies to track reductions in exercise performance when an athlete is fatigued from increased training. The project aims to now refine rHRI so it can also track improvements in exercise performance as athletes recover, and to evaluate rHRI in multiple sports and genders. A field test will be developed and mechanisms that allow it to track changes in exercise performance will be investigated.Read moreRead less
Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliv ....Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliver the knowledge to underpin effective psychological safety and mental health guidelines for community sports with national impact. When implemented, this knowledge will help sports clubs to provide a psychologically safe environment, and promote the mental health and wellbeing of all Australians involved in organised sports.Read moreRead less
Can Exercise Delay Transition To Active Therapy In Men With Low Grade Prostate Cancer? A Multi-Centre Randomized Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$604,429.00
Summary
Prostate cancer overdiagnosis is associated with increased rates of overtreatment and associated morbidity. Although nearly half of Australian men diagnosed with low risk prostate cancer are managed with active surveillance there are no established recommendations for slowing disease progression and delaying transition to active treatment. The proposed study would be the first to determine the efficacy of a comprehensive exercise program during active surveillance for prostate cancer.
Implementing Evidence Into Practice To Improve Chronic Lung Disease Management In Indigenous Australians: The Breathe Easy, Walk Easy-Lungs For Life (BE WELL) Project
Funder
National Health and Medical Research Council
Funding Amount
$780,089.00
Summary
The burden of chronic obstructive pulmonary disease (COPD) in Indigenous Australians far exceeds that in non-Indigenous Australians. The project will evaluate whether the BE WELL program can build the capacity of Aboriginal health workers to provide affordable and effective management of COPD, including pulmonary rehabilitation. This program will improve health outcomes, reduce hospital admissions and address the poor access to best-practice management of COPD in Indigenous communities.
Studies On The Effects Of Endogenous And Exogenous Opioids In Modulating Exercise-induced Dyspnoea In People With Moderate / Severe Chronic Obstructive Pulmonary Disease (COPD). Two Double-blind Randomised, Placebo Controlled Trials.
Funder
National Health and Medical Research Council
Funding Amount
$197,086.00
Summary
There is evidence that morphine-like chemicals made by the body itself help reduce breathlessness. It is not clear whether this response is because of the effects of these morphine-like chemicals on the brain, in the lung or both. This study will help understand where these chemicals act to reduce breathlessness in people with emphysema during exercise. Subsequently, it will also help to understand whether small, regular doses of morphine safely further reduce breathlessness during exercise.
Workplace Interventions To Reduce The Cost Of Neck Problems In Office Personnel
Funder
National Health and Medical Research Council
Funding Amount
$660,834.00
Summary
Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health iss ....Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health issue.Read moreRead less