Pathophysiology Of Focal Human Entrapment Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Neuropathy patients suffer from tingling, pain, numbness, spontaneous muscle contraction and cramp. The symptoms reflect abnormal activation of the nerve involved. It is known that an external agitation can worsen them, like in carpal tunnel syndrome (CTS). This study aims to investigate if changes in function of axonal membrane ion channel play any part in the symptoms. This will be done by comparing axonal membrane ion channel functions of healthy and CTS patients under external stimuli.
Mechanisms Of Autoantibody Mediated Axonal Injury In Inflammatory Demyelinating Neuropathies
Funder
National Health and Medical Research Council
Funding Amount
$580,197.00
Summary
Destruction of nerve fibres (axons) accompanies demyelination and may be responsible for most of the deficit in multiple sclerosis and immune neuropathies. This project will investigate the role of recently described antibodies against a normal component of the axon in axonal damage in both animal models and in patients with immune neuropathies. The project could have a major effect on approaches to management of these diseases.