Venesection Or Expectant Management For Moderate Iron Overload In HFE Related Hereditary Haemochromatosis
Funder
National Health and Medical Research Council
Funding Amount
$853,109.00
Summary
Haemochromatosis is a preventable genetic iron overload disorder. Untreated, it can shorten life due mainly to liver cirrhosis and cancer. It can be prevented by blood donation to maintain normal iron levels. It is unclear, however, whether treatment is necessary when individuals have moderate elevation of iron in the body. This research project will study the effects of treatment in this group by assessing a number of scans, questionnaires and blood tests in treated and untreated individuals.
Matching flotation concentrate composition to downstream processing in copper production at the Olympic Dam operations of BHP Billiton. This research is important for the Australian and South Australian economies. There are both large capital and operating costs benefits if a successful and robust mineral separation can be achieved. Being able to separate different copper sulphide minerals in copper concentrates will have global significance. In the particular case of Olympic Dam mine, the imp ....Matching flotation concentrate composition to downstream processing in copper production at the Olympic Dam operations of BHP Billiton. This research is important for the Australian and South Australian economies. There are both large capital and operating costs benefits if a successful and robust mineral separation can be achieved. Being able to separate different copper sulphide minerals in copper concentrates will have global significance. In the particular case of Olympic Dam mine, the impact of being able to separate the copper sulphide minerals at the mineral processing stage is a significant reduction in operating costs, which is a result of reduced ore handling, mining and smelting costs.Read moreRead less
Early Intervention For Amnestic Mild Cognitive Impairment : A Randomised Trial Of Memory Management
Funder
National Health and Medical Research Council
Funding Amount
$577,556.00
Summary
It is increasingly recognised that Alzheimer’s disease can emerge slowly over years and persons presenting with memory impairment, or mild cognitive impairment (MCI), are at increased risk of developing Alzheimer’s disease. Following diagnosis of MCI, active management through symptomatic drug treatment remains equivocal, therefore, memory impairment continues to be troublesome and patients and families are seeking interventions that offer improvement in quality of life. Cognitive interventions ....It is increasingly recognised that Alzheimer’s disease can emerge slowly over years and persons presenting with memory impairment, or mild cognitive impairment (MCI), are at increased risk of developing Alzheimer’s disease. Following diagnosis of MCI, active management through symptomatic drug treatment remains equivocal, therefore, memory impairment continues to be troublesome and patients and families are seeking interventions that offer improvement in quality of life. Cognitive interventions are low cost and, where effective, can provide a stand-alone intervention or add value to the pharmacological approach. The primary aim of this study is to evaluate whether an early intervention program of memory training is effective in improving use of memory strategies in everyday life, and whether this has psychological and emotional benefits for individuals with MCI and their families. We will evaluate through a randomised controlled trial the efficacy of a memory-group program which will involve the family and patient, rather than just the person with MCI, in developing increased awareness of memory issues and specific strategies to prevent memory failures. Over successive cohorts recruited from memory clinics, families will be randomly assigned to either an immediate intervention or a delayed intervention (waiting-list control) group. We will also recruit a sample of healthy older adults who will be similarly randomised into early and late intervention groups. Healthy older adults will provide a means of establishing whether any improvements in the MCI groups are (i) to the same extent as healthy older adults and (ii) to normative levels. Evaluation will be at pre- and post-intervention and at six months follow-up on tests of memory, questionnaires of knowledge and use of memory strategies in everyday life, and appraisal of level of wellbeing. Information about memory and systematic training in compensatory memory skills are expected to significantly improve the capacity of patients and families to cope with everyday memory difficulties. Through active participation in the management of memory impairment, it is expected that the level of wellbeing will increase, for both patient and families.Read moreRead less
Evaluating Cancer Screening: Context, Evidence, Values And Ethics
Funder
National Health and Medical Research Council
Funding Amount
$572,460.00
Summary
The research and clinical communities are divided over whether certain forms of cancer screening do more harm than good. This project asks: What is the right thing to do about cancer screening now? Using robust qualitative methodologies, we will study real cases of cancer screening and analyse their ethical implications. Drawing on this data and analysis, we will produce tools to help policy-makers, consumers and professionals make good decisions about cancer screening in future.
Evaluating Federal class actions through empirical and comparative perspectives. Sixteen years after the introduction of a Federal class action regime (Part IVA), it is time for an accurate assessment (through an empirical and comparative study) of whether the concerns expressed by numerous commentators - that Part IVA has failed to enhance access to justice and judicial economy and has frequently been abused by the legal representatives of Part IVA parties and litigation funders - are justified ....Evaluating Federal class actions through empirical and comparative perspectives. Sixteen years after the introduction of a Federal class action regime (Part IVA), it is time for an accurate assessment (through an empirical and comparative study) of whether the concerns expressed by numerous commentators - that Part IVA has failed to enhance access to justice and judicial economy and has frequently been abused by the legal representatives of Part IVA parties and litigation funders - are justified. This study will finally provide Australian lawmakers with a detailed reform agenda to ensure that Part IVA will provide the benefits that it was intended to secure whilst operating in a fair and just manner. It will thus benefit similarly situated claimants, respondents, the Federal Court and the broader community.Read moreRead less
Implementing Guidelines To Routinely Prevent Chronic Disease In General Practice
Funder
National Health and Medical Research Council
Funding Amount
$764,446.00
Summary
High quality, evidence-based guidelines for preventive activities and for the implementation of prevention in general practice have been developed by the Royal Australian College of General Practitioners and other bodies, yet available information suggests that many patients miss out on evidence-based preventive care. This project aims to evaluate current practice and develop a model of practice aimed at improving the implementation of preventive guidelines in general practice.
An integrated study of dynamic interactions in soft matter systems. Established Australian pharmaceutical, dairy and food processing industries and growing high-value biotechnology and nanotechnology rely on the processing and control of a generic class of materials called Soft Matter. Cost driven demands for high throughput and increasing water and energy conservation requirements will be met by advances in the underpinning engineering science pursued in this project. In addition to increasing ....An integrated study of dynamic interactions in soft matter systems. Established Australian pharmaceutical, dairy and food processing industries and growing high-value biotechnology and nanotechnology rely on the processing and control of a generic class of materials called Soft Matter. Cost driven demands for high throughput and increasing water and energy conservation requirements will be met by advances in the underpinning engineering science pursued in this project. In addition to increasing the international competitiveness of Australian industries in high value products, the research outcomes also add to the knowledge capacity of the nation for future technological developments.Read moreRead less
Impact of recycled and low quality process water on sustainable mineral processing practices. Water is in short supply and needs to be considered as a 'key reagent'. The quality of this reagent can vary widely. For a sustainable mineral processing practice, the use of recycled or low quality/saline process water will be essential for a plant to operate in the future. The major benefit is recognition that significant recycle of process water for flotation is achievable if simple water quality con ....Impact of recycled and low quality process water on sustainable mineral processing practices. Water is in short supply and needs to be considered as a 'key reagent'. The quality of this reagent can vary widely. For a sustainable mineral processing practice, the use of recycled or low quality/saline process water will be essential for a plant to operate in the future. The major benefit is recognition that significant recycle of process water for flotation is achievable if simple water quality control and management practices are implemented. In addition, a better understanding and control of water quality in recycled/saline process water may lead to improved flotation stability and performance, and reduced reagent consumption.Read moreRead less
Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
What controls trace element levels in ore sulfides? A laser-ICPMS perspective. Sub-surface hydrothermal gold and base metal orebodies are surrounded by aprons of elevated metal concentrations, mainly within micro-sulfides, which is one sign mineral explorers use to widen their target. Here we test whether the hostrock contributes metal in the most distant parts of such halos, and if so, what factors control where hostrock metal begins to be detectable in a given system. We will make better model ....What controls trace element levels in ore sulfides? A laser-ICPMS perspective. Sub-surface hydrothermal gold and base metal orebodies are surrounded by aprons of elevated metal concentrations, mainly within micro-sulfides, which is one sign mineral explorers use to widen their target. Here we test whether the hostrock contributes metal in the most distant parts of such halos, and if so, what factors control where hostrock metal begins to be detectable in a given system. We will make better models of how metalliferous waters react with rock, potentially translating into million dollar savings through more efficient exploration. The ultrafine sampling and precision analyses required for this are possible because of an ARC-funded core program at CODES.Read moreRead less