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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100073
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
High-throughput sample preparation robotics to enable emerging large-scale plant genomics, metabolomics and proteomics research. Discovering and breeding plants that are best suited for new environmental conditions requires the analysis of many samples to discover the underlying genes, metabolites and proteins. The project will build two robotic instruments that will facilitate the rapid grinding and extraction of plant tissues to facilitate these discoveries across Australia.
Accelerating Consolidation and Closure of Mine Tailings Storage Facilities. All mining operations involve the production of waste. Many regard such waste (tailings) and their environmentally acceptable storage as constituting the largest waste problem on Earth because of the enormous damage and loss-of-life that have resulted from failures of tailings storage facilities. This project focuses on a dewatering technology, electro-osmosis (EO), which has yet to be fully operationalised, for improvin ....Accelerating Consolidation and Closure of Mine Tailings Storage Facilities. All mining operations involve the production of waste. Many regard such waste (tailings) and their environmentally acceptable storage as constituting the largest waste problem on Earth because of the enormous damage and loss-of-life that have resulted from failures of tailings storage facilities. This project focuses on a dewatering technology, electro-osmosis (EO), which has yet to be fully operationalised, for improving the strength, stability and settlement characteristics of the tailings. Sophisticated testing will be undertaken at three scales (lab, meso and, most importantly, field), as well as the development of generic numerical models, to create practical guidelines to facilitate the implementation of EO in mines around the world.Read moreRead less
A novel DNA motif involved in plant mitochondrial stress responses. The future of Australia's agriculture is threatened by limited water resources, temperature extremes and soil salinity. This project aims to unravel how plants are able to adapt to this continuously changing environment, by focusing on the role of mitochondria - cellular compartments essential for energy metabolism and plant stress responses.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100027
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Australian National Facility for Noble-Gas Radio-Isotope Measurements. Australian national facility for noble-gas radio-isotope measurements:
This facility is designed to provide researchers with the ability to accurately date water and ice cores using the natural radio-isotopes in the sample. Radiocarbon dating has been a revolutionary tool in providing answers to a range of questions in anthropology, archaeology and the earth sciences. However, radiocarbon dating has a strong limitation in th ....Australian National Facility for Noble-Gas Radio-Isotope Measurements. Australian national facility for noble-gas radio-isotope measurements:
This facility is designed to provide researchers with the ability to accurately date water and ice cores using the natural radio-isotopes in the sample. Radiocarbon dating has been a revolutionary tool in providing answers to a range of questions in anthropology, archaeology and the earth sciences. However, radiocarbon dating has a strong limitation in that it can only date periods from 1000–50 000 years: the use of radioactive noble-gas isotopes can extend this range out to 1 year to 1 million years. This capability in the new facility is expected to support new understanding of processes in artesian reservoirs, ocean currents and geology that may affect questions of water availability, climate and environmental change.Read moreRead less
Safeguarding honeybees: understanding host-parasite interactions at the level of proteins. Parasites are responsible for dramatic declines of honeybee populations resulting in a loss of pollination services and posing a threat to food production and ecosystem stability. This project will study the honeybee immune system and its interactions with bee parasites on the molecular scale, which will be important to guide future bee breeding.
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee vi ....Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee viability. Furthermore, state-of-the-art nanotechnology will be used to develop benign treatments with enhanced effectiveness and minimal dosage/exposure to the bees. Outcomes of this project can have major impact on future parasite management in commercial honeybees.Read moreRead less
The ecology of parasite transmission in fauna translocations. Parasitic diseases pose a threat to the conservation management of Australia's biodiversity. This project will improve our understanding of the impact and transmission of parasites in fauna translocations, contributing to the conservation management of Australian ecosystems by government and private agencies.
The Importance Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung disease is a lifelong problem for people with cystic fibrosis (CF). Blood immune cells called neutrophils swarm the lung and cause ongoing damage. No treatments exist because how CF lungs talk to neutrophils is poorly understood. I will apply new skills from an international neutrophil expert to study samples from AREST CF, a world leading CF research group. This unique combination will recreate the early CF lung in the laboratory, testing triggers of CF lung disease and potential drugs.
Epithelial Drivers Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$849,462.00
Summary
Why airway inflammation becomes chronic so early in life for people with cystic fibrosis (CF) is unclear. This project will use the latest techniques to characterise immune cells found in airways of infants with CF and model in the laboratory how immune cells react to the CF airway. We will challenge CF airway cells with different bugs that can infect the lung, then see if the responses by CF airway cells can change the normal response of immune cells, triggering chronic disease.