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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100064
Funder
Australian Research Council
Funding Amount
$193,125.00
Summary
Sediment Drilling Facility for environmental and genetic archives. This Sediment Drilling Facility for Environmental and Genetic Archives combines versatile augers with new field spectrometers that will enable sediment extraction and rapid, in situ measurements from coastal, lake and riverine environments. The facility includes a compact geotechnical drill rig, a portable power auger with hydraulic extraction unit, a vibracorer with motorised pontoon, laser induced breakdown spectrometer and ma ....Sediment Drilling Facility for environmental and genetic archives. This Sediment Drilling Facility for Environmental and Genetic Archives combines versatile augers with new field spectrometers that will enable sediment extraction and rapid, in situ measurements from coastal, lake and riverine environments. The facility includes a compact geotechnical drill rig, a portable power auger with hydraulic extraction unit, a vibracorer with motorised pontoon, laser induced breakdown spectrometer and magnetic susceptibility. With access co-ordinated through the Queensland Geochronology Alliance, the new facility will enable university researchers unprecedented access to field equipment required to address questions about changing ecology, landscape and climate on recent and geological timescales. Read moreRead less
Depressing pyrite in selective flotation of complex polymetallic ores . This project aims to understand the reactions taking place on the major gangue (waste) mineral during the recovery of base-metal and precious minerals. The mining industry is processing low grade complex ores and experiencing difficulties in rejecting gangue minerals in mineral separation and metal extraction plants. The project will develop new technologies that manipulate these reactions to achieve mineral separation and ....Depressing pyrite in selective flotation of complex polymetallic ores . This project aims to understand the reactions taking place on the major gangue (waste) mineral during the recovery of base-metal and precious minerals. The mining industry is processing low grade complex ores and experiencing difficulties in rejecting gangue minerals in mineral separation and metal extraction plants. The project will develop new technologies that manipulate these reactions to achieve mineral separation and metal extraction efficiently and economically. These technologies may provide value in processing low quality complex polymetallic resources using low quality water, whilst halving the operating costs of mineral concentrators and providing corresponding reductions in harmful emissions.Read moreRead less
How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative e ....How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative evolutionary and genetic approaches, the project proposes to elucidate the mechanism of pathogen blocking and ascertain its broader consequences for the host. This knowledge may be critical for maintaining the effectiveness of the biocontrol approach in the field by informing the development of resistance management strategies.Read moreRead less
Developing a truly intelligent water meter through advanced data analytics. Developing a truly intelligent water meter through advanced data analytics. This project aims to develop intelligent pattern recognition algorithms using international data sets to autonomously categorise household water consumption data into end-uses (e.g. showers, leaks). Despite intelligent meters, big data chokes rather than enables decision making for customers and utilities. This project will resolve information sy ....Developing a truly intelligent water meter through advanced data analytics. Developing a truly intelligent water meter through advanced data analytics. This project aims to develop intelligent pattern recognition algorithms using international data sets to autonomously categorise household water consumption data into end-uses (e.g. showers, leaks). Despite intelligent meters, big data chokes rather than enables decision making for customers and utilities. This project will resolve information synthesis concerns using a combination of non-linear blind source separation techniques adapted from the pattern recognition, signal processing and decision science fields. Expected outcomes are that utilities will be leaders of sustainable water use in the information age, and that customers can use phones to access real-time data of water consumption.Read moreRead less
Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Transport and innate immune properties of DNA in bacterial nano-sized vesicles. All types of living organisms release nano-sized membrane vesicles or “blebs” which they use for intercellular communication and transport of molecules. This project will determine how bacteria package DNA within these vesicles, how this DNA is transported into host cells and how it triggers immune responses in these cells.
An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling w ....An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling with a novel experimental protocol to allow the study of kinetics of parasite replication in vivo. Expected outcomes will provide significant benefits, such as new avenues for vaccination and immune intervention.Read moreRead less
The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic c ....The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.Read moreRead less