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Accelerating Consolidation and Closure of Mine Tailings Storage Facilities. All mining operations involve the production of waste. Many regard such waste (tailings) and their environmentally acceptable storage as constituting the largest waste problem on Earth because of the enormous damage and loss-of-life that have resulted from failures of tailings storage facilities. This project focuses on a dewatering technology, electro-osmosis (EO), which has yet to be fully operationalised, for improvin ....Accelerating Consolidation and Closure of Mine Tailings Storage Facilities. All mining operations involve the production of waste. Many regard such waste (tailings) and their environmentally acceptable storage as constituting the largest waste problem on Earth because of the enormous damage and loss-of-life that have resulted from failures of tailings storage facilities. This project focuses on a dewatering technology, electro-osmosis (EO), which has yet to be fully operationalised, for improving the strength, stability and settlement characteristics of the tailings. Sophisticated testing will be undertaken at three scales (lab, meso and, most importantly, field), as well as the development of generic numerical models, to create practical guidelines to facilitate the implementation of EO in mines around the world.Read moreRead less
Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair b ....Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair bonding by identifying the brain regions, cell types and neurochemicals that promote pair bonding behaviour — for the first time in a wild animal. This project should provide significant benefits by increasing our knowledge of how pair bonds promote wellness.Read moreRead less
Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combin ....Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combination of historical and ecological approaches. The project expects to showcase the evolution and uniqueness of Australia’s native biota.Read moreRead less
Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unpreced ....Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unprecedented system, backed by 37 years of long term host-parasite and behavioural data, and recent genetic analyses. This project intends to produce significant data to allow an examination of the early stages of host-parasite evolution in action, providing novel insights into the speciation process. Read moreRead less
Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in ....Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation. The outcomes of the project will create new fundamental knowledge that in the future can instruct the development of the next generation of biomaterials capable of controlling and directing the body’s inflammatory responses.Read moreRead less
Organisms and Us: How Living Things Help Us To Understand Our World. How do researchers learn from and 'think with' non-human organisms? This project seeks to develop a comprehensive historical and philosophical exploration of the changing roles and understandings of research with organisms in 20th and early 21st century science. Advances in the content and technologies of the biological and biomedical sciences have resulted in new understandings of what we can know and learn from organisms, par ....Organisms and Us: How Living Things Help Us To Understand Our World. How do researchers learn from and 'think with' non-human organisms? This project seeks to develop a comprehensive historical and philosophical exploration of the changing roles and understandings of research with organisms in 20th and early 21st century science. Advances in the content and technologies of the biological and biomedical sciences have resulted in new understandings of what we can know and learn from organisms, particularly with regard to human functioning, health, and well-being, yet we have no integrated scholarship examining these developments across a range of fields. This project seeks to produce useful scholarship relevant for humanities scholars, scientists, clinicians and policy-makers.Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
Early African woodworking and tool use at the transition to modern humans. Our archaeological excavations and preliminary dating of Amanzi Springs (South Africa) to between 515,000 and 163,000 years ago shows that the site covers a critical time period that led to the origins of our species, Homo sapiens. Amanzi documents, in never before seen resolution, the technological leaps that our ancestors made during this transition. At ~400,000 years ago this includes the oldest evidence for woodworkin ....Early African woodworking and tool use at the transition to modern humans. Our archaeological excavations and preliminary dating of Amanzi Springs (South Africa) to between 515,000 and 163,000 years ago shows that the site covers a critical time period that led to the origins of our species, Homo sapiens. Amanzi documents, in never before seen resolution, the technological leaps that our ancestors made during this transition. At ~400,000 years ago this includes the oldest evidence for woodworking and tool use and >163,000 years ago the oldest heat treatment of rock to make stone tools. The organic preservation at the site means that we can reconstruct changing environment, linked to sea level changes and spring activity, for this period in the evolution of our ancestors at a level of detail not previously possibleRead moreRead less
To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key peo ....To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key people involved in each sector to determine their views on the ways in which our food supply affects our health. It will result in policy recommendations advising how the Australian food sector can be made more supportive of health and equity. Policy makers will be engaged with our findings through a Food Policy Summit. Read moreRead less