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Function And Inhibition Of Plasmepsin V In Targeting Malaria Virulence Proteins Into Human Erythrocytes
Funder
National Health and Medical Research Council
Funding Amount
$407,845.00
Summary
Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cel ....Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cell.Read moreRead less
Infectious diseases plague mankind; with infections responsible for approximately 20% of all deaths worldwide. New strategies are urgently needed and we have positioned our research to address questions around how to forestall bacterial pathogens in the initial phases of invasion of human tissues and provide full understanding of the key molecules on the surfaces of bacterial cells. This fundamental knowledge is crucial to new drugs, vaccines and infection-resistant medical devices.
Development of advanced ceramic membranes: a robust solution to sustainable water treatment. Australia is one of the driest nations on Earth. While available fresh water supplies dwindle, options to treat 'used' water for reuse are gaining rapid popularity. Membranes are now state-of-the-art for water treatment, including all new desalination plants, but as they are polymeric based, they must be routinely cleaned with chemicals and replaced. The outcomes of this research will demonstrate innovat ....Development of advanced ceramic membranes: a robust solution to sustainable water treatment. Australia is one of the driest nations on Earth. While available fresh water supplies dwindle, options to treat 'used' water for reuse are gaining rapid popularity. Membranes are now state-of-the-art for water treatment, including all new desalination plants, but as they are polymeric based, they must be routinely cleaned with chemicals and replaced. The outcomes of this research will demonstrate innovative functional ceramic membranes which last longer and have lower requirement for cleaning chemicals and expert maintenance. This, in turn, will deliver water at lower cost and reduced environmental burden (chemical and membrane disposal), giving industry more sustainable solutions to treat water, which has now become an essential practice in society.Read moreRead less
Certified evaluation of uncertainty in models of dynamical systems. The purpose of this project is to develop methods which will aid engineers to better analyse the accuracy of models created using experimental data. To support the use of the methods, a toolbox with software implementations will also be developed.
Hybrid Construction using Seawater, Sea Sand and Fibre Reinforced Polymer. Conventional concrete is made using fresh water and river sand. This project aims to develop a novel hybrid construction system using seawater, sea sand and industrial waste, together with fibre reinforced polymer (FRP) and stainless steel (SS), for use in civil engineering infrastructure in marine environments. To date there has been little work to understand the degradation kinetics and mechanisms of FRP and SS in such ....Hybrid Construction using Seawater, Sea Sand and Fibre Reinforced Polymer. Conventional concrete is made using fresh water and river sand. This project aims to develop a novel hybrid construction system using seawater, sea sand and industrial waste, together with fibre reinforced polymer (FRP) and stainless steel (SS), for use in civil engineering infrastructure in marine environments. To date there has been little work to understand the degradation kinetics and mechanisms of FRP and SS in such complicated corrosive environments. The project plans to provide a design methodology to ensure confidence in the safety of critical infrastructure such as bridges, highways, dams, airports, offshore piles and artificial islands. The proposed system would save fresh water and reduce damage to river ecosystems, carbon dioxide emissions and construction costs.Read moreRead less
Smart Polymer Hydrogels for Simultaneous Waste Heat Utilisation and Wastewater Treatment for Sustainable Manufacturing. This project aims to develop dual-functionality, temperature-responsive polymer hydrogels as draw agents for continuous, forward osmosis wastewater treatment processes. It intends to use low–and-medium temperature waste heat as a green input into the process and thus significantly reduce the costs of wastewater treatment, and fresh water consumption, whilst effectively utilisin ....Smart Polymer Hydrogels for Simultaneous Waste Heat Utilisation and Wastewater Treatment for Sustainable Manufacturing. This project aims to develop dual-functionality, temperature-responsive polymer hydrogels as draw agents for continuous, forward osmosis wastewater treatment processes. It intends to use low–and-medium temperature waste heat as a green input into the process and thus significantly reduce the costs of wastewater treatment, and fresh water consumption, whilst effectively utilising waste heat generated in the manufacturing industry. The outcomes of this research aim to provide a unique opportunity for Australian researchers to become world leaders in the rapidly-emerging, energy-efficient forward osmosis technology which is very relevant not only to wastewater treatment, but also to desalination.Read moreRead less
Designing textured roughness to control turbulent pipe flow. This project will combine a recent theoretical model of turbulent pipe flow with computer simulation to develop methods to control these flows (e.g. to increase mixing, reduce wall drag). Additionally we will extend the model so it can deal with many industrially significant flows of fluids carrying high concentrations of fine particles.
We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately exp ....We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately explore the relationship between prothesis wear and PO, or the progression of PO, because of a lack of techniques to image and measure the volume of PO around metal prosthesis components. We have developed a means to accurately and reproducibly measure the volume of bone loss, using CT, and will do so longitudinally in joint replacement patients to obtain the first information about the progression of PO. New computer based methods will be used concurrently to relate prosthesis wear and migration parameters to PO. Patients who come to surgery for replacement of failed prostheses will be investigated further by analysis of the tissues involved in the bone loss around prostheses. Basic science experiments will seek to understand the underlying causes of PO and the findings will be important in interpreting the clinical results. An animal model will be used to seek approaches to inhibiting the pathological response to wear particles. The significance of these studies is that they will lead to improved outcomes for joint replacement patients, increasing the interval to revision surgery, which is both extremely costly and brings an attendant morbidity and mortality.Read moreRead less
Designing for scale: understanding the value of information and communication technologies for individuals, communities and movements. This project will build an understanding of how we can design information systems to have a positive, significant impact at different human scales: individual, community and society at large. Using software that advises individuals on how much water to use in their gardens, the project will question how this vehicle can effect large-scale change in our communitie ....Designing for scale: understanding the value of information and communication technologies for individuals, communities and movements. This project will build an understanding of how we can design information systems to have a positive, significant impact at different human scales: individual, community and society at large. Using software that advises individuals on how much water to use in their gardens, the project will question how this vehicle can effect large-scale change in our communities.Read moreRead less
Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies ....Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies of hydro-climate forecasting, with federal, state and regional water agencies.Read moreRead less