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Characterisation of novel gene products that regulate phospholipid metabolism and lipid droplet formation in the yeast saccharomyces cerevisiae. This project aims to study gene products that control lipid storage in the form of lipid droplets. The biogenesis and composition of lipid droplets in plant seeds or algae determine the quantity and quality of oil/biodiesel production.
Genome wide screening for gene products that regulate the celluar dynamics of lipid droplets. Obesity is a pandemic that if not stopped, will lead to huge social and economic problems in Australia. In essence, the hallmark of human obesity is the accumulation of cellular lipid droplets. This research will benefit Australia by providing a fundamental understanding of how lipid droplets are formed. This will have immediate international impact at the scientific level and will also provide novel ta ....Genome wide screening for gene products that regulate the celluar dynamics of lipid droplets. Obesity is a pandemic that if not stopped, will lead to huge social and economic problems in Australia. In essence, the hallmark of human obesity is the accumulation of cellular lipid droplets. This research will benefit Australia by providing a fundamental understanding of how lipid droplets are formed. This will have immediate international impact at the scientific level and will also provide novel targets and strategies for treating obesity. The proposed study will also benefit Australian agriculture by providing strategies to improve oil production from plant seeds. Read moreRead less
The cellular dynamics of lipid droplets: implications for obesity and biodiesel production. Obesity is a pandemic that if not stopped, will lead to huge social and economic problems in Australia. In essence, the hallmark of human obesity is the accumulation of cellular lipid droplets. This research will benefit Australia by providing a fundamental understanding of how lipid droplets are formed. This will have immediate international impact at the scientific level and will also identify novel com ....The cellular dynamics of lipid droplets: implications for obesity and biodiesel production. Obesity is a pandemic that if not stopped, will lead to huge social and economic problems in Australia. In essence, the hallmark of human obesity is the accumulation of cellular lipid droplets. This research will benefit Australia by providing a fundamental understanding of how lipid droplets are formed. This will have immediate international impact at the scientific level and will also identify novel compounds and strategies for treating obesity. The proposed study will also benefit Australian agriculture and energy industry by providing strategies to improve the production of plant oil and biodiesel. Read moreRead less
The role of phospholipids in the biogenesis of lipid droplets. The general aim is to elucidate the fundamental molecular mechanisms that govern the biogenesis/formation of the lipid droplets. Lipid droplets store sterol esters and/or triacylglycerols, two major storage lipids that play key roles in cellular and whole body lipid metabolism. Lipid droplets are also the core components of plant oil and biodiesel. Little is known about how lipid droplets are generated. The proposed work will examine ....The role of phospholipids in the biogenesis of lipid droplets. The general aim is to elucidate the fundamental molecular mechanisms that govern the biogenesis/formation of the lipid droplets. Lipid droplets store sterol esters and/or triacylglycerols, two major storage lipids that play key roles in cellular and whole body lipid metabolism. Lipid droplets are also the core components of plant oil and biodiesel. Little is known about how lipid droplets are generated. The proposed work will examine the synthesis of certain lipid intermediates such as phosphatidic acid, and their impact on the biogenesis of lipid droplets from the endoplasmic reticulum. Such fundamental new knowledge on how cells store neutral lipids will provide new strategies for enhancing plant oil and biodiesel production. Read moreRead less