Role Of The Ets-family Transcription Factor Erg In Haematopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$100,621.00
Summary
Development of blood cells is controlled by specific molecules called transcription factors. Transcription factors are important in developing mature white cells, red cells and platelets from blood stem cells. We have discovered that a transcription factor, Erg, is important in control of blood stem cells and blood cell development as well as being implicated in human cancers, including acute leukaemia. This project will characterise how this molecule is involved in these specific processes.
Investigating The Mechanisms Underpinning The Dynamic Vessel Response In People With Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$18,808.00
Summary
Endothelial dysfunction has been well-hypothesised as one of the key players in the pathogenesis of DR. However, there is strong evidence suggesting a neurovascular coupling mechanism in the retinal circulation during flicker. It is therefore unclear whether reduced flicker light induced vasodilation observed in diabetes and DR is associated with endothelial dysfunction, an impairment of neurovascular coupling or both. This project aims to address this important knowledge gap.