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Cell Type Specific Mechanisms Of Mineralocorticoid Mediated Renal Injury In Glomerulonephritis And Diabetic Nephropathy
Funder
National Health and Medical Research Council
Funding Amount
$103,582.00
Summary
Mineralocorticoid exists normally in the human body to maintain fluid and salt balance. However, it is also implicated in diseases affecting the heart and the kidneys. My research aims to further our understanding on how mineralocorticoids contribute to kidney disease, and in particular, to investigate the role of specific kidney cells on mediating kidney injury. Ultimately this research may facilitate development of treatments allowing cell specific blockade of mineralocorticoids, which may red ....Mineralocorticoid exists normally in the human body to maintain fluid and salt balance. However, it is also implicated in diseases affecting the heart and the kidneys. My research aims to further our understanding on how mineralocorticoids contribute to kidney disease, and in particular, to investigate the role of specific kidney cells on mediating kidney injury. Ultimately this research may facilitate development of treatments allowing cell specific blockade of mineralocorticoids, which may reduce kidney diseases such as diabetic nephropathy.Read moreRead less
Vitamin D And Genetic Susceptibility In Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Vitamin D3 levels appear to predict clinical status in multiple sclerosis. The reasons for this are unclear, but may be linked to the effect of the Vitamin D Receptor (VDR) on a subset of immune cells. This project aims to identify key genes which are regulated by this receptor, by using specific gene sequencing technologies combined with knowledge of the genes which confer risk of developing MS. This may help to identify the molecular pathways underlying MS and potential treatment strategies.
A Novel Approach To Cytokine Blockade For The Treatment Of Systemic Lupus Erythematosus
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Lupus is a disease of the immune system which can cause inflammation and damage to many organs and even death, often affecting young people in their prime of life. Current treatments are limited and often have undesirable side effects. Certain cells and molecules are thought to be responsible for causing lupus. This project will examine the effect of blocking one of these molecules as a means of treating lupus. It will also use gene and protein analysis of samples from lupus patients to see if r ....Lupus is a disease of the immune system which can cause inflammation and damage to many organs and even death, often affecting young people in their prime of life. Current treatments are limited and often have undesirable side effects. Certain cells and molecules are thought to be responsible for causing lupus. This project will examine the effect of blocking one of these molecules as a means of treating lupus. It will also use gene and protein analysis of samples from lupus patients to see if response to treatments can be predicted.Read moreRead less
CD300f As A Novel Therapeutic Antibody Target In Acute Myeloid Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$89,926.00
Summary
This study aims to develop a new antibody therapy for Acute Myeloid Leukaemia (AML), the most common type of leukaemia in adults. We will study the function of CD300f, a new receptor found on the surface of both healthy blood cells and the cancer cells in AML. We will investigate whether blocking this receptor with a newly developed antibody can be used to kill cancer cells. It is hoped that this study will allow development of this antibody for use in a future clinical trial.
Identification And Chracterization Of Host Cell Receptors For Influenza A Viruses
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Following inhalation, influenza virus infects cells of the immune system and epithelial cells lining the airways. Currently, it is not clear how influenza virus attaches to and infects these cells. This project will use new ways to identify receptors for influenza virus on human epithelial cells and immune cells. The ultimate identification of these receptors would have important implications for the development of new drugs to treat influenza virus infections.
The Adaptive Immune Response To Epstein-Barr Virus.
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Epstein-Barr virus (EBV), the causative agent of glandular fever, is carried by a large proportion of adults worldwide. EBV is known to cause many cancers including Burkitt's lymphoma and has been linked to autoimmune diseases such as multiple sclerosis. The aim of this project is to find new fragments of EBV that the body's immune system can recognise and use to protect itself against the virus. Once found these pieces will form parts of the puzzle that will one day combine as a vaccine against ....Epstein-Barr virus (EBV), the causative agent of glandular fever, is carried by a large proportion of adults worldwide. EBV is known to cause many cancers including Burkitt's lymphoma and has been linked to autoimmune diseases such as multiple sclerosis. The aim of this project is to find new fragments of EBV that the body's immune system can recognise and use to protect itself against the virus. Once found these pieces will form parts of the puzzle that will one day combine as a vaccine against EBV.Read moreRead less
Appendicitis, Protection Again Colitis And The Role Of Colonic Regulatory T Cells
Funder
National Health and Medical Research Council
Funding Amount
$67,381.00
Summary
The appendix has been regarded as a useless organ, however, there are evidence showing its removal reduces the risk of developing inflammatory bowel disease. We have shown that this may be due to altered intestinal immune regulation. The project plans to explore the mechanisms responsible for this altered immune regulation. With knowledge of specific elements of disease causation gained from these studies, more effective and targeted treatment options will become available.
The Role Of Redox Regulation In Controlling The Oncogenic Function Of Eph Receptors
Funder
National Health and Medical Research Council
Funding Amount
$71,766.00
Summary
Reactive oxygen species (ROS) produced in cancers activate cell surface receptor signalling pathways that drive cancer progression. I will study links between ROS and receptor signalling in cancer cells, and inhibit signalling with ROS scavengers delivered in nanoparticles, targeted to receptor complexes with specific antibodies. These will include antibodies we raised against ADAM10, a protease associated with multiple receptor signalling pathways, to simultaneously inhibit these pathways.
Exploring Models For Antibody Mediated Endocrine Disease
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
Common endocrine disorders like Graves’ disease, are mediated by auto-antibodies, causing uncontrolled hormonal expression and undesirable effects. However, due to the limited understanding of the antibody interactions, the treatment is still focused on controlling the hormone production/interactions instead of targeting the underlying autoimmune processes. This project aims to further characterise the role the antibody through animal studies and developing novel treatments based on the research ....Common endocrine disorders like Graves’ disease, are mediated by auto-antibodies, causing uncontrolled hormonal expression and undesirable effects. However, due to the limited understanding of the antibody interactions, the treatment is still focused on controlling the hormone production/interactions instead of targeting the underlying autoimmune processes. This project aims to further characterise the role the antibody through animal studies and developing novel treatments based on the research.Read moreRead less
Targeted Molecular Therapies And Predictive Biomarkers In A Novel Orthotopic Xenograft Model Of Oesophageal Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
Oesophageal cancer is the most rapidly increasing malignancy in Western society. This disease often presents in advanced stages with poor response to established medical and surgical therapies. Our aim is to develop a novel mouse model of oesophageal cancer, allowing us to tailor cancer-inhibiting molecular treatments to individual patients by predicting therapeutic success or resistance with the use of cellular markers identified in our animal mode.