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The Role Of Food Components In The Modification Of Colorectal Cancer Risk At The Epigenomic Level.
Funder
National Health and Medical Research Council
Funding Amount
$28,609.00
Summary
Colorectal cancer represents a substantial burden to the health system. Primary prevention rather than treatment is more cost effective and can reduce morbidity and mortality. This study program will contribute to the emerging research area of nutrigenomics and nutritional epigenomics, by investigating the interaction between nutrition and gene expression. Such research can assist in establishing a diet which can best help to prevent colorectal cancer, at an individual or population level.
Differentiation Of Murine Embryonic Stem Cells To The Female Germ Line
Funder
National Health and Medical Research Council
Funding Amount
$57,342.00
Summary
In this project we aim to establish techniques to obtain viable and developmentally competent eggs from embryonic stem (ES) cells for studies on the molecular and cellular mechanisms of sex cell production. We expect to achieve ES cell derived eggs with similar fertilization and developmental potential as eggs developed naturally. Sterility resulting from cancer treatments and from genetic and non-genetic malformations can benefit from this ES cell therapy.
Epigenetics Of Human Placental Development And Pregnancy-associated Disease.
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
Mounting evidence suggests that epigenetic changes such as DNA methylation during pregnancy may play an important role in adverse pregnancy outcomes and modulation of disease risk later in life. We have identified a range of distinct DNA methylation events in human placental cells that are likely to play a role in both normal human placentation and aspects of placental dysfunction. We believe that disruption of this epigenetic profile contributes to adverse pregnancy outcomes