Mapping the effect of social enterprise on regional city disadvantage. This project aims to explore how social enterprises affect wellbeing and community capacity in disadvantaged areas of regional cities. Governments increasingly invest in social enterprise to benefit individuals and places. This project will use a spatial methodology to map where and how benefits are realised. To date, robust evidence about how social enterprise affects disadvantage is lacking, partly due to inadequate researc ....Mapping the effect of social enterprise on regional city disadvantage. This project aims to explore how social enterprises affect wellbeing and community capacity in disadvantaged areas of regional cities. Governments increasingly invest in social enterprise to benefit individuals and places. This project will use a spatial methodology to map where and how benefits are realised. To date, robust evidence about how social enterprise affects disadvantage is lacking, partly due to inadequate research methodology. This project expects to provide web-based design tools and applications to assist regional city communities and councils in the development of social enterprises that can help disadvantaged people and places.Read moreRead less
Challenging the stigmatisation of poverty and place-based disadvantage. There is widespread community tolerance for using demeaning and derisory stereotypes to describe individuals experiencing poverty and socioeconomic disadvantage. This negative stereotyping, which also attaches to neighbourhoods with high proportions of disadvantaged households, has many adverse effects and undermines poverty reduction efforts. The proposed research will examine the influence of the media on wider community a ....Challenging the stigmatisation of poverty and place-based disadvantage. There is widespread community tolerance for using demeaning and derisory stereotypes to describe individuals experiencing poverty and socioeconomic disadvantage. This negative stereotyping, which also attaches to neighbourhoods with high proportions of disadvantaged households, has many adverse effects and undermines poverty reduction efforts. The proposed research will examine the influence of the media on wider community attitudes to poverty and socioeconomic disadvantage in Australia and the United Kingdom, develop an innovative method for research involving populations vulnerable to being stigmatised, and generate new knowledge of the effects of poverty stigma. Findings will inform strategies for challenging stigma. Read moreRead less
Social futures and life pathways of young people in Queensland: waves 4 and 5 of a longitudinal study. This project assesses the impact of globalisation on the attitudes, behaviors, and life pathways of a cohort of over 7000 young Queenslanders, first surveyed when they were aged 12 and 13. Participants will be followed up when they are aged 19 and 20 and 20/21 to examine their experiences of the transition from school to work, family and social life.
Social Futures & Life Pathways of Young People in Queensland: Waves 6 & 7. This project plans to extend a large longitudinal study of young people in Queensland to investigate the impact of social, political and economic changes on educational, workforce, partnering, family and housing transitions in early adulthood. The project is designed to combine large-scale survey research with in-depth qualitative interviewing to track stability and change in the values, aspirations, health and wellbeing ....Social Futures & Life Pathways of Young People in Queensland: Waves 6 & 7. This project plans to extend a large longitudinal study of young people in Queensland to investigate the impact of social, political and economic changes on educational, workforce, partnering, family and housing transitions in early adulthood. The project is designed to combine large-scale survey research with in-depth qualitative interviewing to track stability and change in the values, aspirations, health and wellbeing of a cohort of young people who were first surveyed as secondary school students a decade earlier. This aims to inform social policy by identifying factors that promote positive career, relationship, housing and health outcomes for young adults, and those which place young adults at risk of unemployment, tertiary non-completion, residential and relationship instability, and poorer mental and physical wellbeing.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that ....Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that the partnership between UTAS and Bestenbalt LLC is a critical step in the development of these exciting research discoveries into commercially viable outcomes for the Australian Biotechnology Industry and the broader Australian community.Read moreRead less
Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These a ....Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These are significant community issues in both economical and social terms. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest cellular processes associated with aging or disease of the brain, and will provide clues to promoting healthy aging.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson' ....The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson's disease patients whose timing performance is impaired due to dopaminergic dysfunction. We expect TMS inhibitory effects to induce predictable performance trends, providing support for the accumulator model and the key role of the SMA in timing.Read moreRead less