Tapasin And Major Histocompatibility Complex Class I Antigen Presentation
Funder
National Health and Medical Research Council
Funding Amount
$226,650.00
Summary
An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. ....An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.Read moreRead less
Global production networks and worker representation in Myanmar. This project aims to assess the impact of global production networks on worker representation in Myanmar’s garment sector, which is leading the country’s integration into global supply chains at this crucial time in its economic and political development. This project’s findings will be used to theorise how complex interactions between different economic and social actors across geographic scale affect the rights and interests of g ....Global production networks and worker representation in Myanmar. This project aims to assess the impact of global production networks on worker representation in Myanmar’s garment sector, which is leading the country’s integration into global supply chains at this crucial time in its economic and political development. This project’s findings will be used to theorise how complex interactions between different economic and social actors across geographic scale affect the rights and interests of garment workers, and the quality of their employment. This will provide significant benefits that will make an important contribution to scholarly understandings of the impact of labour agency on global production networks and provide a strong evidence base for decision-making by local and international stakeholders.Read moreRead less
Ending long-term homelessness permanently: How to make effective links between housing and long-term support. Australian services for homeless people typically provide short to medium-term assistance and accommodation. This approach struggles to meet the complex needs of the long-term homeless. Recently there has been considerable government investment in new approaches to end long-term homelessness, but evidence supporting the efficacy of these approaches is limited. This project builds on a fo ....Ending long-term homelessness permanently: How to make effective links between housing and long-term support. Australian services for homeless people typically provide short to medium-term assistance and accommodation. This approach struggles to meet the complex needs of the long-term homeless. Recently there has been considerable government investment in new approaches to end long-term homelessness, but evidence supporting the efficacy of these approaches is limited. This project builds on a four year Randomised Controlled Trial of the Journey to Social Inclusion pilot-program which was designed to end long-term homelessness. The project aims to track participants for an additional two years. The research aims to provide new knowledge on what practices and factors generate positive outcomes and what factors and practices sustain positive outcomes.Read moreRead less
Hunger for Change: Student Food Insecurity and Youth Agency in Australia. Rising food prices threaten to exacerbate an already pressing problem of food insecurity among students in Australia universities. This project will examine the causes, consequences, and nature of food insecurity among students in Australia employing interviews, focus groups and participant observation. It will contribute to scholarly debates on food security and youth agency through highlighting the imaginative ways in wh ....Hunger for Change: Student Food Insecurity and Youth Agency in Australia. Rising food prices threaten to exacerbate an already pressing problem of food insecurity among students in Australia universities. This project will examine the causes, consequences, and nature of food insecurity among students in Australia employing interviews, focus groups and participant observation. It will contribute to scholarly debates on food security and youth agency through highlighting the imaginative ways in which young people are developing responses to food insecurity. The project will offer the Australian government, State governments and universities opportunities to build upon student-led solutions to food insecurity, enhance capacity for research on food and youth issues, and heighten public understanding of the issue.Read moreRead less
The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connection ....The time of our lives: Time equity and the balancing of market and non-market production in the modern Australian population. This project will yield new information relevant to the national social inclusion agenda and the research priority goal of understanding and strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, fulfilling lives. Through a multilayered analysis of gender, class, life course stage, time allocation and the connections between them, it will demonstrate links between various forms of social and economic participation and identify how they could be distributed more evenly. This knowledge is important to inform policy to better enable young people to become independent, families to both earn a living and care well for their children, and older people to be productive and socially engaged.Read moreRead less
Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected ....Designing Gender Equality into the Future of Work. This project aims to investigate how women and men understand and experience the changing nature of work and their hopes and fears for the future. This project expects to generate new knowledge about the gendered dimensions of workplace change using an innovative and engaged research design that focuses on retail and the law, two areas where women are increasingly dominant, but which are located at distinct ends of the labour market. Expected outcomes of this project include an enhanced and coordinated capacity to build gender equality into the future of work. This should provide significant benefits such as better living standards for individuals and families and improved profitability and productivity for businesses. Read moreRead less
Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income familie ....Families at the centre: negotiating Australia's mixed market in early education and care. Despite a surge of policy reforms and Australian government investment in early childhood education and care (ECEC), little is known in Australia about how local ECEC markets function and how low-income families make decisions about the use or non-use of child care services. This project will provide evidence for policy-making and service provision that aims to encourage child care use by low-income families. The direct involvement of child care providers in the research will strengthen its relevance and impact. This research will place Australia at the forefront of international research on local child care markets, and resulting improvements in ECEC policy and services will generate substantial economic and social benefits.Read moreRead less
Social transformation and international migration in the 21st century. Understanding the factors that shape international migration is crucial for Australia, because planned immigration remains a cornerstone of policy, yet traditional assumptions on the predominance of permanent settlement and the geographical controllability of movement are losing their validity. This project will help create the social scientific tools for new approaches to understanding migration and diversity at the global, ....Social transformation and international migration in the 21st century. Understanding the factors that shape international migration is crucial for Australia, because planned immigration remains a cornerstone of policy, yet traditional assumptions on the predominance of permanent settlement and the geographical controllability of movement are losing their validity. This project will help create the social scientific tools for new approaches to understanding migration and diversity at the global, regional and national levels. It will help Australian governments and civil society address new challenges in this field. It will also contribute to developing a highly-trained workforce for fundamental research on migration and social transformation. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101178
Funder
Australian Research Council
Funding Amount
$344,324.00
Summary
Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degr ....Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degree to which water harvesting leads to social inclusion or exclusion. Through ethnographic examinations of the water values, resource subjectivities and power dynamics that influence the success of urban water harvesting, the projects intends to gain insights to improve regional water policy and aid effectiveness.Read moreRead less