The development of novel oligosaccharides from dairy lactose for improved infant nutrition. This project will develop new milk sugars to enhance nutrition for the 46 per cent of infants who receive formula. It will support rural and regional dairy communities and manufacturers increasing innovation, potentially generating six million dollars in new sales per annum, increasing returns to farmers and promoting regional employment and spending.
Industrial biotechnology for improved manufacture of medicinal alkaloids. Industrial biotechnology for improved manufacture of medicinal alkaloids. This project aims to develop a new semi-synthetic route for the manufacture of Codeine from Thebaine. Codeine is manufactured by the chemical conversion of poppy-derived Morphine, which is low yielding and environmentally unfriendly. This project will investigate and optimise two key enzymes in the biosynthetic pathway to Codeine and develop an innov ....Industrial biotechnology for improved manufacture of medicinal alkaloids. Industrial biotechnology for improved manufacture of medicinal alkaloids. This project aims to develop a new semi-synthetic route for the manufacture of Codeine from Thebaine. Codeine is manufactured by the chemical conversion of poppy-derived Morphine, which is low yielding and environmentally unfriendly. This project will investigate and optimise two key enzymes in the biosynthetic pathway to Codeine and develop an innovative bioreactor to achieve high yield. It will research industrial biotransformations, providing a greener and cheaper process for increased global access to Codeine. Australian opiate manufacturing is expected to benefit from value adding and increased flexibility introduced by a biotechnology approach.Read moreRead less
Algal direct-air CO2 capture through interfacial enzyme immobilisation . Capturing CO2 directly from the atmosphere is challenging due to inherently slow mass transfer kinetics. This project aims to overcome this using an enzyme that can rapidly solubilise CO2 from air into water, to produce algae. By engineering the enzyme immobilisation at the air-water interface, this project will activate and protect the enzymes, increasing their lifespan and reducing costs. By understanding mass transfer an ....Algal direct-air CO2 capture through interfacial enzyme immobilisation . Capturing CO2 directly from the atmosphere is challenging due to inherently slow mass transfer kinetics. This project aims to overcome this using an enzyme that can rapidly solubilise CO2 from air into water, to produce algae. By engineering the enzyme immobilisation at the air-water interface, this project will activate and protect the enzymes, increasing their lifespan and reducing costs. By understanding mass transfer and enzyme activity in the interfacial immobilisation media, floating enzyme rafts can be developed for deployment over expansive areas, facilitating large-scale conversion of atmospheric CO2 into algae-derived fuels, feeds and chemicals.Read moreRead less
Industrial biotechnology for the manufacture of alkaloid pharmaceuticals. Drugs that treat opioid dependence and overdose are increasingly needed but their manufacture is difficult, inefficient and expensive. This project aims to develop enzymatic N-demethylation as a simpler and more sustainable approach to the manufacture and modification of opioid antagonists, alkaloids and other drug targets. It will increase our understanding of enzymatic N-demethylation and address engineering and biotechn ....Industrial biotechnology for the manufacture of alkaloid pharmaceuticals. Drugs that treat opioid dependence and overdose are increasingly needed but their manufacture is difficult, inefficient and expensive. This project aims to develop enzymatic N-demethylation as a simpler and more sustainable approach to the manufacture and modification of opioid antagonists, alkaloids and other drug targets. It will increase our understanding of enzymatic N-demethylation and address engineering and biotechnology challenges to improve yield and product isolation and concentration. Improvements in drug manufacturing processes will assist drug affected communities and industry will benefit from value adding, greater market share and flexibility, increased innovation and de-risked processes and new products. Read moreRead less
Novel enzymatic processing methods and stabilization technologies for omega-3 oils. New and existing lipases will be applied to the concentration of omega-3 lipids from fish and algal oils. The primary aim of this project is to replace current chemical processes and high temperature distillation with milder enzymatic methods, providing high quality omega-3 concentrates for food and pharmaceutical purposes. The project aims to develop new immobilisation technology to enable multiple re-use of lip ....Novel enzymatic processing methods and stabilization technologies for omega-3 oils. New and existing lipases will be applied to the concentration of omega-3 lipids from fish and algal oils. The primary aim of this project is to replace current chemical processes and high temperature distillation with milder enzymatic methods, providing high quality omega-3 concentrates for food and pharmaceutical purposes. The project aims to develop new immobilisation technology to enable multiple re-use of lipases for the cost effective production of omega-3 concentrates and to apply new microencapsulation strategies to the stabilisation of omega-3 concentrates, enabling the delivery of omega-3s and other bioactive ingredients to a range of food and beverage products.Read moreRead less